Nutrient Sensing by Hypothalamic Tanycytes [PDF]
Nutritional signals have long been implicated in the control of cellular processes that take place in the hypothalamus. This includes food intake regulation and energy balance, inflammation, and most recently, neurogenesis.
Roberto Javier Elizondo-Vega +2 more
doaj +5 more sources
ATP-mediated glucosensing by hypothalamic tanycytes [PDF]
The hypothalamus contains key neural circuits involved in the control of feeding and energy balance. Stimulated by the inexorable rise of obesity, there has been intense study of these neural circuits.
Cameron Frayling +5 more
core +3 more sources
Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice [PDF]
Tanycytes contribute to the regulation of multiple hypothalamic functions. Here the authors investigate the regenerative and tumorigenic potential of adult Rax+ tanycytes in the median eminence in the context of the stem cell niche in mice.
Wenhui Mu +10 more
doaj +2 more sources
Tanycytes: morphology and functions: a review. [PDF]
The chapter presents a review of the morphology and functions of tanycytes. The name “tanycyte,” derived from the Greek word “tanus,” which means “elongated,” was chosen to stress the shape of these bipolar cells, in relation at their apical pole with ...
Flament Durand, Jacqueline +3 more
core +3 more sources
MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction. [PDF]
Metabolic interaction via lactate between glial cells and neurons has been proposed as one of the mechanisms involved in hypothalamic glucosensing. We have postulated that hypothalamic glial cells, also known as tanycytes, produce lactate by glycolytic ...
Christian Cortés-Campos +5 more
doaj +2 more sources
Tanycyte-Independent Control of Hypothalamic Leptin Signaling [PDF]
Leptin is secreted by adipocytes to regulate appetite and body weight. Recent studies have reported that tanycytes actively transport circulating leptin across the brain barrier into the hypothalamus, and are required for normal levels of hypothalamic ...
Sooyeon Yoo +8 more
doaj +4 more sources
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
The hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes ...
Helge Müller-Fielitz +12 more
doaj +2 more sources
Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism [PDF]
peer reviewedEstrogen secretion by the ovaries regulates the hypothalamic-pituitary-gonadal axis during the reproductive cycle, influencing gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion, and also plays a role in regulating ...
Florent Sauve +2 more
exaly +4 more sources
Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging [PDF]
Effective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a
Viana Q. Pham +6 more
doaj +2 more sources
Summary: Here, we present a protocol for tanycyte-neuron paired whole-cell patch-clamp recording in living mouse brain slices. We describe steps for mice generation, solution preparation, and dissection.
Tori Lhomme, Vincent Prévot
doaj +2 more sources

