Results 11 to 20 of about 161 (83)
Scientific Reports, 2022 Feeding behavior is a complex process that depends on the ability of the brain to integrate hormonal and nutritional signals, such as glucose. One glucosensing mechanism relies on the glucose transporter 2 (GLUT2) in the hypothalamus, especially in ...
M. J. Barahona +6 more
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Ontogeny of ependymoglial cells lining the third ventricle in mice
Frontiers in Endocrinology, 2023 IntroductionDuring hypothalamic development, the germinative neuroepithelium gives birth to diverse neural cells that regulate numerous physiological functions in adulthood.MethodsHere, we studied the ontogeny of ependymal cells in the mouse mediobasal ...
David Lopez-Rodriguez +5 more
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Tany-Seq: Integrated Analysis of the Mouse Tanycyte Transcriptome
Cells, 2022 The ability to maintain energy homeostasis is necessary for survival. Recently, an emerging role for ependymogial cells, which line the third ventricle in the hypothalamus in the regulation of energy homeostasis, has been appreciated.
Andrew I. Sullivan +2 more
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Glial functions in the blood-brain communication at the circumventricular organs
Frontiers in Neuroscience, 2022 The circumventricular organs (CVOs) are located around the brain ventricles, lack a blood-brain barrier (BBB) and sense blood-derived molecules. This review discusses recent advances in the importance of CVO functions, especially glial cells transferring
Seiji Miyata
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TSPO: an emerging role in appetite for a therapeutically promising biomarker
Open Biology, 2021 There is accumulating evidence that an obesogenic Western diet causes neuroinflammatory damage to the brain, which then promotes further appetitive behaviour. Neuroinflammation has been extensively studied by analysing the translocator protein of 18 kDa (
Joshua Wang, Kate Beecher
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Neural Progenitor Cells and the Hypothalamus
Cells, 2023 Neural progenitor cells (NPCs) are multipotent neural stem cells (NSCs) capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes.
Evanthia A. Makrygianni +1 more
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Glial Glucokinase Expression in Adult and Post-Natal Development of the Hypothalamic Region
ASN Neuro, 2010 It has recently been proposed that hypothalamic glial cells sense glucose levels and release lactate as a signal to activate adjacent neurons. GK (glucokinase), the hexokinase involved in glucose sensing in pancreatic β-cells, is also expressed in the ...
Carola Millán +10 more
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Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries
Frontiers in Endocrinology, 2019 Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate ...
Adair Rodríguez-Rodríguez +6 more
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Tanycyte-Independent Control of Hypothalamic Leptin Signaling
Frontiers in Neuroscience, 2019 Leptin is secreted by adipocytes to regulate appetite and body weight. Recent studies have reported that tanycytes actively transport circulating leptin across the brain barrier into the hypothalamus, and are required for normal levels of hypothalamic ...
Sooyeon Yoo +8 more
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A single-cell transcriptomic study of heterogeneity in human embryonic tanycytes
Scientific ReportsDisruptions in energy homeostasis can lead to diseases like obesity and diabetes, affecting millions of people each year. Tanycytes, the adult stem cells in the hypothalamus, play crucial roles in assisting hypothalamic neurons in maintaining energy ...
Yiguang Bai, Qiaoling Chen, Yuan Li
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