Tanycyte-Independent Control of Hypothalamic Leptin Signaling [PDF]
Frontiers in Neuroscience, 2019 Leptin is secreted by adipocytes to regulate appetite and body weight. Recent studies have reported that tanycytes actively transport circulating leptin across the brain barrier into the hypothalamus, and are required for normal levels of hypothalamic ...
Dong Won Kim +2 more
exaly +4 more sources
Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes [PDF]
Frontiers in Neuroscience, 2022 Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche.
Alex Moore +33 more
doaj +6 more sources
Tany-Seq: Integrated Analysis of the Mouse Tanycyte Transcriptome
Cells, 2022 The ability to maintain energy homeostasis is necessary for survival. Recently, an emerging role for ependymogial cells, which line the third ventricle in the hypothalamus in the regulation of energy homeostasis, has been appreciated.
Matthew J Potthoff +2 more
exaly +3 more sources
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice
Molecular Metabolism, 2021 Objectives: Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in mice
Antoine Rohrbach +8 more
doaj +2 more sources
Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis [PDF]
Nature Communications, 2023 The median eminence (ME) at the base of the brain controls body homeostasis. Here, the authors describe a functional tanycyte subpopulation at the ME which tastes the surrounding milieu, responds to metabolic signals and regulates glucose homeostasis.
Qiang Yu +21 more
doaj +5 more sources
Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia
Frontiers in Neuroscience, 2023 The hypothalamus is a key regulator of several homeostatic processes, such as circadian rhythms, energy balance, thirst, and thermoregulation. Recently, the hypothalamic third ventricle has emerged as a site of postnatal neurogenesis and gliogenesis ...
Harmony Fong +5 more
doaj +1 more source
Glial functions in the blood-brain communication at the circumventricular organs
Frontiers in Neuroscience, 2022 The circumventricular organs (CVOs) are located around the brain ventricles, lack a blood-brain barrier (BBB) and sense blood-derived molecules. This review discusses recent advances in the importance of CVO functions, especially glial cells transferring
Seiji Miyata
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Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain
Cells, 2022 Oligodendrogenesis is essential for replacing worn-out oligodendrocytes, promoting myelin plasticity, and for myelin repair following a demyelinating injury in the adult mammalian brain.
Daniel Z. Radecki, Jayshree Samanta
doaj +1 more source
Irx3 and Irx5 - Novel Regulatory Factors of Postnatal Hypothalamic Neurogenesis
Frontiers in Neuroscience, 2021 The hypothalamus is a brain region that exhibits highly conserved anatomy across vertebrate species and functions as a central regulatory hub for many physiological processes such as energy homeostasis and circadian rhythm. Neurons in the arcuate nucleus
Zhengchao Dou +4 more
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Ontogeny of ependymoglial cells lining the third ventricle in mice
Frontiers in Endocrinology, 2023 IntroductionDuring hypothalamic development, the germinative neuroepithelium gives birth to diverse neural cells that regulate numerous physiological functions in adulthood.MethodsHere, we studied the ontogeny of ependymal cells in the mouse mediobasal ...
David Lopez-Rodriguez +5 more
doaj +1 more source