Tanycyte-Independent Control of Hypothalamic Leptin Signaling [PDF]
Frontiers in Neuroscience, 2019 Leptin is secreted by adipocytes to regulate appetite and body weight. Recent studies have reported that tanycytes actively transport circulating leptin across the brain barrier into the hypothalamus, and are required for normal levels of hypothalamic ...
Sooyeon Yoo, Dong Won Kim, Thanh Hoang
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Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone–Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation [PDF]
ResearchExcessive gonadotropin-releasing hormone (GnRH) is considered to be an initiating factor in the etiology of polycystic ovary syndrome (PCOS). GnRH neuronal axons terminate at the hypothalamic arcuate nucleus and median eminence, where tanycytes ...
Yu Wang +12 more
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Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia [PDF]
Frontiers in Neuroscience, 2023 The hypothalamus is a key regulator of several homeostatic processes, such as circadian rhythms, energy balance, thirst, and thermoregulation. Recently, the hypothalamic third ventricle has emerged as a site of postnatal neurogenesis and gliogenesis ...
Harmony Fong +5 more
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Seasonal changes in activity of hypothalamic thyroid hormone system in different winter phenotypes of Djungarian hamster (Phodopus sungorus). [PDF]
PLoS ONEAlthough the Djungarian hamster (Phodopus sungorus) is a seasonality model, it presents substantial variability in winter acclimation. In response to short photoperiod, some individuals express a suite of winter traits such as low body mass, regressed ...
Anna S Przybylska-Piech +2 more
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Potential role of tanycyte-derived neurogenesis in Alzheimer’s disease [PDF]
Neural Regeneration ResearchTanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance.
Guibo Qi +4 more
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Tany-Seq: Integrated Analysis of the Mouse Tanycyte Transcriptome
Cells, 2022 The ability to maintain energy homeostasis is necessary for survival. Recently, an emerging role for ependymogial cells, which line the third ventricle in the hypothalamus in the regulation of energy homeostasis, has been appreciated.
Andrew I Sullivan +2 more
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Fasting induces metabolic switches and spatial redistributions of lipid processing and neuronal interactions in tanycytes [PDF]
Nature CommunicationsThe ependyma lining the third ventricle (3V) in the mediobasal hypothalamus plays a crucial role in energy balance and glucose homeostasis. It is characterized by a high functional heterogeneity and plasticity, but the underlying molecular mechanisms ...
Maxime Brunner +9 more
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Ontogeny of ependymoglial cells lining the third ventricle in mice [PDF]
Frontiers in Endocrinology, 2023 IntroductionDuring hypothalamic development, the germinative neuroepithelium gives birth to diverse neural cells that regulate numerous physiological functions in adulthood.MethodsHere, we studied the ontogeny of ependymal cells in the mouse mediobasal ...
David Lopez-Rodriguez +5 more
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Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis [PDF]
Nature Communications, 2023 The median eminence (ME) at the base of the brain controls body homeostasis. Here, the authors describe a functional tanycyte subpopulation at the ME which tastes the surrounding milieu, responds to metabolic signals and regulates glucose homeostasis.
Qiang Yu +21 more
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Protocol for simultaneous patch-clamp recording from tanycytes and neurons in living mouse brain slices [PDF]
STAR Protocols, 2023 Summary: Here, we present a protocol for tanycyte-neuron paired whole-cell patch-clamp recording in living mouse brain slices. We describe steps for mice generation, solution preparation, and dissection.
Tori Lhomme, Vincent Prévot
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