Results 11 to 20 of about 797 (157)

Nutrient Sensing by Hypothalamic Tanycytes [PDF]

Frontiers in Endocrinology, 2019
Nutritional signals have long been implicated in the control of cellular processes that take place in the hypothalamus. This includes food intake regulation and energy balance, inflammation, and most recently, neurogenesis.
Roberto Javier Elizondo-Vega, Antonia Recabal, Karina Oyarce   +2 more
doaj   +3 more sources

Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome [PDF]

Chinese Medicine
Background Polycystic ovary syndrome (PCOS) is a complex neuroendocrine disorder characterized by dysregulation of the hypothalamus. Both electroacupuncture (EA) and manual acupuncture (MA) have demonstrated therapeutic efficacy in the treatment of PCOS ...
Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng   +9 more
doaj   +2 more sources

Tanycytic G6PT silencing prevents obesity induced by early postnatal overnutrition [PDF]

Scientific Reports
Tanycytes are ependymal glial cells that express the glucose-6-phosphate transporter (G6PT), which facilitates the incorporation of phosphorylated glucose from the cytosol into the reticular lumen.
María José Barahona, Matías Vera, Carol Gajardo, Francisca López, Paul San Martín, Francisco Nualart   +5 more
doaj   +2 more sources

Adenosine transmission from hypothalamic tanycytes to AGRP/NPY neurons regulates energy homeostasis [PDF]

Experimental and Molecular Medicine
Tanycytes are a pivotal component of the hypothalamic network that controls energy homeostasis. Despite their importance, the regulatory mechanisms governing tanycyte–neuron interactions in response to metabolic signals remain unexplored.
Nayoun Kim, Seolsong Kim, Seokjae Park, Eun-Kyoung Kim   +3 more
doaj   +2 more sources

Knocking down the neuronal lactate transporter MCT2 in the arcuate nucleus of female rats increases food intake and body weight [PDF]

Scientific Reports
In the arcuate nucleus of the hypothalamus, tanycyte-neuron interactions regulate glucose homeostasis and feeding behavior. Previously, we reported that monocarboxylate transporters (MCT) 1 and 4 are localized in tanycytes, whereas MCT2 is present in ...
Alanis Coca, Sergio López, Patricio Órdenes, Vania Sepúlveda, Diego Cuevas, Andrés Villarroel, Javiera Álvarez-Indo, Patricia V. Burgos, Estefanía Tarifeño, Roberto Elizondo-Vega, María A García-Robles   +10 more
doaj   +2 more sources

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes-A Cautionary Tale. [PDF]

FASEB Bioadv
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tao T, Leon-Palmer N, DiPietro S, Townsend KL.   +3 more
europepmc   +2 more sources

ESCHR: a hyperparameter-randomized ensemble approach for robust clustering across diverse datasets [PDF]

Genome Biology
Clustering is widely used for single-cell analysis, but current methods are limited in accuracy, robustness, ease of use, and interpretability. To address these limitations, we developed an ensemble clustering method that outperforms other methods at ...
Sarah M. Goggin, Eli R. Zunder
doaj   +2 more sources

Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes

Frontiers in Neuroscience, 2022
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche.
Alex Moore, Alex Moore, Alex Moore, Kavitha Chinnaiya, Kavitha Chinnaiya, Kavitha Chinnaiya, Dong Won Kim, Sarah Brown, Sarah Brown, Sarah Brown, Iain Stewart, Iain Stewart, Iain Stewart, Sarah Robins, Sarah Robins, Sarah Robins, Georgina K. C. Dowsett, Georgina K. C. Dowsett, Charlotte Muir, Marco Travaglio, Jo E. Lewis, Jo E. Lewis, Fran Ebling, Seth Blackshaw, Seth Blackshaw, Seth Blackshaw, Seth Blackshaw, Seth Blackshaw, Andrew Furley, Andrew Furley, Andrew Furley, Marysia Placzek, Marysia Placzek, Marysia Placzek   +33 more
doaj   +1 more source

Perspective: rheostasis revisited-hibernation and tanycytes. [PDF]

J Comp Physiol B
Abstract Mammalian hibernation is a physiological and behavioural adaptation that permits survival during seasonal periods of energy shortage via a combination of pre-hibernal energy storage and hibernal metabolic depression (torpor).
Wood SH.
europepmc   +3 more sources

Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Molecular Metabolism, 2021
Objectives: Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in mice
Antoine Rohrbach, Emilie Caron, Rafik Dali, Maxime Brunner, Roxane Pasquettaz, Irina Kolotuev, Federico Santoni, Bernard Thorens, Fanny Langlet   +8 more
doaj   +1 more source