Results 11 to 20 of about 373 (115)

Potential role of tanycyte-derived neurogenesis in Alzheimer’s disease

Neural Regeneration Research
Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance.
Guibo Qi, Han Tang, Jianian Hu, Siying Kang, Song Qin   +4 more
doaj   +2 more sources

Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis [PDF]

Frontiers in Endocrinology, 2019
Animal survival relies on a constant balance between energy supply and energy expenditure, which is controlled by several neuroendocrine functions that integrate metabolic information and adapt the response of the organism to physiological demands ...
Fanny Langlet
doaj   +2 more sources

Fasting induces metabolic switches and spatial redistributions of lipid processing and neuronal interactions in tanycytes

Nature Communications
The ependyma lining the third ventricle (3V) in the mediobasal hypothalamus plays a crucial role in energy balance and glucose homeostasis. It is characterized by a high functional heterogeneity and plasticity, but the underlying molecular mechanisms ...
Maxime Brunner, David Lopez-Rodriguez, Judith Estrada-Meza, Rafik Dali, Antoine Rohrbach, Tamara Deglise, Andrea Messina, Bernard Thorens, Federico Santoni, Fanny Langlet   +9 more
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Adenosine transmission from hypothalamic tanycytes to AGRP/NPY neurons regulates energy homeostasis

Experimental and Molecular Medicine
Tanycytes are a pivotal component of the hypothalamic network that controls energy homeostasis. Despite their importance, the regulatory mechanisms governing tanycyte–neuron interactions in response to metabolic signals remain unexplored.
Nayoun Kim, Seolsong Kim, Seokjae Park, Eun-Kyoung Kim   +3 more
doaj   +2 more sources

Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption

Stem Cell Reports, 2017
Summary: Chronic alcohol abuse results in alcohol-related neurodegeneration, and critical gaps in our knowledge hinder therapeutic development. Neural stem cells (NSCs) are a subpopulation of cells within the adult brain that contribute to brain ...
Erica L. McGrath, Junling Gao, Yong-Fang Kuo, Tiffany J. Dunn, Moniqua J. Ray, Kelly T. Dineley, Kathryn A. Cunningham, Bhupendra S. Kaphalia, Ping Wu   +8 more
doaj   +2 more sources

Nutrient Sensing by Hypothalamic Tanycytes [PDF]

Frontiers in Endocrinology, 2019
Nutritional signals have long been implicated in the control of cellular processes that take place in the hypothalamus. This includes food intake regulation and energy balance, inflammation, and most recently, neurogenesis.
Roberto Javier Elizondo-Vega, Antonia Recabal, Karina Oyarce   +2 more
doaj   +2 more sources

Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network [PDF]

Frontiers in Cellular Neuroscience, 2018
Tanycytes are hypothalamic radial glia-like cells that form the basal wall of the third ventricle (3V) where they sense glucose and modulate neighboring neuronal activity to control feeding behavior.
Antonia Recabal, Roberto Elizondo-Vega, Camille Philippot, Magdiel Salgado, Sergio López, Alejandra Palma, Estefanía Tarifeño-Saldivia, Aline Timmermann, Gerald Seifert, Teresa Caprile, Christian Steinhäuser, María Angeles García-Robles   +11 more
doaj   +2 more sources

Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma

, 2020
International audienceTanycytes are highly specialized ependymal cells that line the bottom and the lateral walls of the third ventricle. In contact with the cerebrospinal fluid through their cell bodies, they send processes into the arcuate nucleus, the
Cathy Gouelle, Roxane Pasquettaz, Rohrbach, Antoine, Irina Kolotuev, Langlet, Fanny, Kolotuev, Irina, Fanny Langlet, Pasquettaz, Roxane, Antoine Rohrbach, Luc Pellerin, Pellerin, Luc, Gouelle, Cathy, Rohrbach, A., Langlet, F., Gouelle C, Langlet F, Pasquettaz R, Kolotuev I, Pellerin L, Pellerin, L., Kolotuev, I., Pasquettaz, R., Gouelle, C., Rohrbach A   +23 more
core   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF MONOCARBOXYLATE TRANSPORTER 1&4 IN TANYCYTE–LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM

The Iraqi Journal of Medical Sciences, 2019
Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider F. Jawad, Muthanna A. Al-Kaabi, Anam R. Al-Salihi   +2 more
doaj   +6 more sources

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

Cell Reports, 2017
The hypothalamus is one of the most complex brain structures involved in homeostatic regulation. Defining cell composition and identifying cell-type-specific transcriptional features of the hypothalamus is essential for understanding its functions and ...
Renchao Chen, Xiaoji Wu, Lan Jiang, Yi Zhang   +3 more
doaj   +1 more source