Results 1 to 10 of about 101,827 (258)
Viruses, 2015 Tight junctions (TJs) are highly specialized membrane domains involved in many important cellular processes such as the regulation of the passage of ions and macromolecules across the paracellular space and the establishment of cell polarity in ...
Jesus Torres Flores +2 more
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PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation [PDF]
Nature CommunicationsTight junctions are crucial for maintaining intestinal barrier homeostasis, but how organisms modulate these junctions remain unclear. Here, we show a role for PEAK1 at cell-cell contact sites, where it interacts with ZO-1 via a conserved region spanning
Zaikuan Zhang +12 more
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Tight Junctions in Cell Proliferation [PDF]
International Journal of Molecular Sciences, 2019 Tight junction (TJ) proteins form a continuous intercellular network creating a barrier with selective regulation of water, ion, and solutes across endothelial, epithelial, and glial tissues. TJ proteins include the claudin family that confers barrier properties, members of the MARVEL family that contribute to barrier regulation, and JAM molecules ...
Xuwen Liu +2 more
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The role of ZEB1 in regulating tight junctions in antrochoanal polyp [PDF]
HeliyonBackground: Antrochoanal polyp (ACP) is a benign nasal mass of unknown etiology. Tight junctions (TJs) are essential to the epithelial barrier that protects the body from external damage.
Yisha Wu +7 more
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Molecules, 2021 Glaesserella parasuis (G. parasuis) causes inflammation and damage to piglets. Whether polyserositis caused by G. parasuis is due to tight junctions damage and the protective effect of baicalin on it have not been examined.
Jiacheng Zhang +7 more
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Editorial: Regulation of permeability of tight junctions [PDF]
Frontiers in Cell and Developmental BiologyClaudia Tanja Mierke
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Nanoscale segregation of channel and barrier claudins enables paracellular ion flux
Nature Communications, 2022 Meshworks of claudin polymers control the paracellular transport and barrier properties of epithelial tight junctions. Here, the authors show different claudin nanoscale organization principles, finding that claudin segregation enables barrier formation ...
Hannes Gonschior +10 more
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Microorganisms, 2023 Extracellular glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has multiple interactions with various gut epithelial components. For instance, GAPDH in Lactobacillus johnsonii MG cells interacts with junctional adhesion molecule-2 (JAM-2) in Caco-2 cells
Mengying Lyu +4 more
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Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the
Li Zuo, Wei-Ting Kuo, Jerrold R. Turner
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Tight junctions at a glance [PDF]
Journal of Cell Science, 2008 Tight junctions (TJs) are morphologically distinct and highly regulated areas of close contact between the plasma membranes of neighbouring epithelial and endothelial cells. They are the most apical component of the epithelial junctional complex (which also includes adherens junctions and ...
Maria S, Balda, Karl, Matter
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