Results 1 to 10 of about 105,063 (116)

PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation [PDF]

Nature Communications
Tight junctions are crucial for maintaining intestinal barrier homeostasis, but how organisms modulate these junctions remain unclear. Here, we show a role for PEAK1 at cell-cell contact sites, where it interacts with ZO-1 via a conserved region spanning
Zaikuan Zhang, Yajun Xie, Qiying Yi, Jianing Liu, Lin Yang, Runzhi Wang, Jing Cai, Xinyi Li, Xiaosong Feng, Shixiang Yao, Zheng Pan, Magdalena Paolino, Qin Zhou   +12 more
doaj   +2 more sources

The role of ZEB1 in regulating tight junctions in antrochoanal polyp [PDF]

Heliyon
Background: Antrochoanal polyp (ACP) is a benign nasal mass of unknown etiology. Tight junctions (TJs) are essential to the epithelial barrier that protects the body from external damage.
Yisha Wu, Dingqian Hao, Yanyi Tu, Lin Chen, Peng Yu, Aiping Chen, Yuzhu Wan, Li Shi   +7 more
doaj   +2 more sources

Protective Effects of Baicalin on Peritoneal Tight Junctions in Piglets Challenged with Glaesserella parasuis

Molecules, 2021
Glaesserella parasuis (G. parasuis) causes inflammation and damage to piglets. Whether polyserositis caused by G. parasuis is due to tight junctions damage and the protective effect of baicalin on it have not been examined.
Jiacheng Zhang, Zhaoran Zhang, Jianfeng Xu, Chun Ye, Shulin Fu, Chien-An Andy Hu, Yinsheng Qiu, Yu Liu   +7 more
doaj   +1 more source

Editorial: Regulation of permeability of tight junctions [PDF]

Frontiers in Cell and Developmental Biology
Claudia Tanja Mierke
doaj   +2 more sources

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux

Nature Communications, 2022
Meshworks of claudin polymers control the paracellular transport and barrier properties of epithelial tight junctions. Here, the authors show different claudin nanoscale organization principles, finding that claudin segregation enables barrier formation ...
Hannes Gonschior, Christopher Schmied, Rozemarijn Eva Van der Veen, Jenny Eichhorst, Nina Himmerkus, Jörg Piontek, Dorothee Günzel, Markus Bleich, Mikio Furuse, Volker Haucke, Martin Lehmann   +10 more
doaj   +1 more source

GAPDH Released from Lactobacillus johnsonii MG Enhances Barrier Function by Upregulating Genes Associated with Tight Junctions

Microorganisms, 2023
Extracellular glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has multiple interactions with various gut epithelial components. For instance, GAPDH in Lactobacillus johnsonii MG cells interacts with junctional adhesion molecule-2 (JAM-2) in Caco-2 cells
Mengying Lyu, Yuying Bai, Kanami Orihara, Kazuhiko Miyanaga, Naoyuki Yamamoto   +4 more
doaj   +1 more source

Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the
Li Zuo, Wei-Ting Kuo, Jerrold R. Turner
doaj   +1 more source

FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. [PDF]

PLoS ONE, 2013
Proper development and tissue maintenance requires cell-cell adhesion structures, which serve diverse and crucial roles in tissue morphogenesis. Epithelial tissues have three main types of cell-cell junctions: tight junctions, which play a major role in ...
Henry P Foote, Kaelyn D Sumigray, Terry Lechler   +2 more
doaj   +1 more source

Adherens, tight, and gap junctions in ependymal cells: A systematic review of their contribution to CSF-brain barrier

Frontiers in Neurology, 2023
IntroductionThe movement of fluids and solutes across the ependymal barrier, and their changes in physiologic and disease states are poorly understood.
Riccardo Serra, J. Marc Simard, J. Marc Simard, J. Marc Simard   +3 more
doaj   +1 more source

Protective effects of inhalation of essential oils from Mentha piperita leaf on tight junctions and inflammation in allergic rhinitis

Frontiers in Allergy, 2022
Allergic rhinitis is one of the most common diseases, which is caused by IgE-mediated reactions to inhaled allergens. Essential oils from the Mentha piperita leaf (EOM) are known to be effective for various diseases, such as respiratory diseases. However,
Nayoung Park, Jae Yoon Chung, Mi Hye Kim, Woong Mo Yang   +3 more
doaj   +1 more source