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Intestinal Barrier, Claudins and Mycotoxins
Toxins, 2021 The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact
Marta Justyna Kozieł +2 more
exaly +4 more sources
Deciphering the role of claudins in lung cancer [PDF]
Frontiers in OncologyLung cancer remains a major global health challenge, characterized by aggressive malignancy and poor prognostic outcomes. This review article focuses on the pivotal role of claudins, a family of tight junction proteins, in the pathophysiology of lung ...
Abderrahman Ouban +2 more
exaly +4 more sources
On the Interaction of Clostridium perfringens Enterotoxin with Claudins
Toxins, 2010 Clostridium perfringens causes one of the most common foodborne illnesses, which is largely mediated by the Clostridium perfringens enterotoxin (CPE). The toxin consists of two functional domains.
Gerd Krause +2 more
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Expression patterns of claudins in cancer
Heliyon, 2023 Claudins are four-transmembrane proteins, which were found in tight junctions. They maintain cell barriers and regulate cell differentiation and proliferation. They are involved in maintaining cellular polarity and normal functions.
Zhou Chengjun, Hui Li, Bingxin Guan
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Interaction analysis of tight junction proteins by Förster resonance energy transfer is recommended in live cells rather than after paraformaldehyde fixation [PDF]
Frontiers in PhysiologyThe tight junction regulates the paracellular passage of solutes and water. It is primarily constituted by the family of claudins which assemble to huge multimers and basically seal the paracellular cleft.
Catrin Przibylla-Diop +3 more
doaj +2 more sources
Simulated Mars Gravity Impairs Intestinal Epithelial Barrier Integrity via Selective Modulation of Tight Junction Components [PDF]
BiomoleculesFuture long-duration human space missions will expose astronauts to chronically reduced gravitational loading, a condition associated with oxidative stress and epithelial barrier dysfunction.
Laura Benvenuti +11 more
doaj +2 more sources
Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects
Frontiers in Cell and Developmental Biology, 2023 Genitourinary (GU) cancers are among the most prevalent neoplasms in the world, with bladder cancers constituting 3% of global cancer diagnoses. However, several pathogenetic mechanisms remain controversial and unclear.
Tarek Ziad Arabi +4 more
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Context-Dependent Roles of Claudins in Tumorigenesis
Frontiers in Oncology, 2021 The barrier and fence functions of the claudin protein family are fundamental to tissue integrity and human health. Increasing evidence has linked claudins to signal transduction and tumorigenesis. The expression of claudins is frequently dysregulated in
Jian Li
doaj +1 more source
Informatics in Medicine Unlocked, 2022 Claudins are a class of transmembrane proteins in the family of tight junction (TJ) proteins. The disrupted functioning of claudins has been found to have a role in urolithiasis (Kidney stones).
Anirudh Gururaj Patil +4 more
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Cells, 2022 Claudins are a family of integral membrane proteins that enable epithelial cell/cell interactions by localizing to and driving the formation of tight junctions.
Chinemerem P. Ogbu +2 more
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