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European Journal of Histochemistry, 2012 I am pretty sure that I don’t have to spend a single word to talk about the role played by tight junctions in biological processes and in keeping alive the cellular bases of life !
Carlo Alberto Redi
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Claudins in lung diseases [PDF]
Respiratory Research, 2011 Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions.
Soini Ylermi
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Claudins: Beyond Tight Junctions in Human IBD and Murine Models
Frontiers in Pharmacology, 2021 Claudins are transmembrane proteins constituting one of three tight junction protein families. In patients with inflammatory bowel disease (IBD), disease activity–dependent changes in expression of certain claudins have been noted, thus making certain ...
Brankica Mijandrušić-Sinčić +1 more
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Deciphering the role of claudins in lung cancer [PDF]
Frontiers in OncologyLung cancer remains a major global health challenge, characterized by aggressive malignancy and poor prognostic outcomes. This review article focuses on the pivotal role of claudins, a family of tight junction proteins, in the pathophysiology of lung ...
Tarek Ziad Arabi +2 more
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On the Interaction of Clostridium perfringens Enterotoxin with Claudins
Toxins, 2010 Clostridium perfringens causes one of the most common foodborne illnesses, which is largely mediated by the Clostridium perfringens enterotoxin (CPE). The toxin consists of two functional domains.
Jonas Protze +2 more
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Expression patterns of claudins in cancer
Heliyon, 2023 Claudins are four-transmembrane proteins, which were found in tight junctions. They maintain cell barriers and regulate cell differentiation and proliferation. They are involved in maintaining cellular polarity and normal functions.
Bingxin Guan, Hui Li
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Claudins in the Renal Collecting Duct [PDF]
International Journal of Molecular Sciences, 2019 The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis. The collecting duct epithelium is comprised of a tight epithelial barrier resulting in a strict separation of intraluminal urine and the
Janna Leiz, Kai M. Schmidt-Ott
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Interaction analysis of tight junction proteins by Förster resonance energy transfer is recommended in live cells rather than after paraformaldehyde fixation [PDF]
Frontiers in PhysiologyThe tight junction regulates the paracellular passage of solutes and water. It is primarily constituted by the family of claudins which assemble to huge multimers and basically seal the paracellular cleft.
Catrin Przibylla-Diop +3 more
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Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects
Frontiers in Cell and Developmental Biology, 2023 Genitourinary (GU) cancers are among the most prevalent neoplasms in the world, with bladder cancers constituting 3% of global cancer diagnoses. However, several pathogenetic mechanisms remain controversial and unclear.
Tarek Ziad Arabi +2 more
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Structure and function of claudins
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008 Claudins are tetraspan transmembrane proteins of tight junctions. They determine the barrier properties of this type of cell-cell contact existing between the plasma membranes of two neighbouring cells, such as occurring in endothelia or epithelia. Claudins can completely tighten the paracellular cleft for solutes, and they can form paracellular ion ...
Krause, Gerd +5 more
openaire +3 more sources