Results 31 to 40 of about 14,180 (293)

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux [PDF]

, 2022
The paracellular passage of ions and small molecules across epithelia is controlled by tight junctions, complex meshworks of claudin polymers that form tight seals between neighboring cells.
Furuse, Mikio, Günzel, Dorothee, Van der Veen, Rozemarijn Eva, Gonschior, Hannes, Schmied, Christopher, Eichhorst, Jenny, Himmerkus, Nina, Bleich, Markus, Haucke, Volker, Lehmann, Martin, Piontek, Jörg   +10 more
core   +1 more source

Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients

Frontiers in Oncology, 2020
High-grade serous ovarian carcinoma (HGSOC) usually spreads directly into the peritoneal cavity following a transcoelomic dissemination route, although distant hematogenous metastasis exist and have been reported.
Chiara Romani, Chiara Romani, Valentina Zizioli, Marco Silvestri, Marco Silvestri, Laura Ardighieri, Mattia Bugatti, Michela Corsini, Paola Todeschini, Sergio Marchini, Maurizio D'Incalci, Laura Zanotti, Antonella Ravaggi, Antonella Ravaggi, Antonella Ravaggi, Fabio Facchetti, Angela Gambino, Angela Gambino, Franco Odicino, Franco Odicino, Enrico Sartori, Enrico Sartori, Alessandro Davide Santin, Stefania Mitola, Eliana Bignotti, Eliana Bignotti, Stefano Calza, Stefano Calza   +27 more
doaj   +1 more source

Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.

PLoS ONE, 2017
Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability.
Shinsaku Tokuda, Toyohiro Hirai, Mikio Furuse   +2 more
doaj   +1 more source

Barriers built on claudins [PDF]

Journal of Cell Science, 2004
The fundamental functions of epithelia and endothelia in multicellular organisms are to separate compositionally distinct compartments and regulate the exchange of small solutes and other substances between them. Tight junctions (TJs) between adjacent cells constitute the barrier to the passage of ions and molecules through the paracellular pathway and
Kursad, Turksen, Tammy-Claire, Troy
openaire   +2 more sources

Functional Analysis of Gastric Tight Junction Proteins in Xenopus laevis Oocytes

Membranes, 2022
The epithelial barrier is crucial for proper gastrointestinal function, preventing the unwanted passage of solutes and therefore representing a prerequisite for vectorial transport.
Laura Stein, Nora Brunner, Salah Amasheh
doaj   +1 more source

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Food & Nutrition Research, 2022
Background: Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells.
Hui-Xin Zhang, Ye-Ye Li, Zhong-Jie Liu, Jiu-Feng Wang   +3 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Antibody-mediated targeting of Claudins in cancer

Frontiers in Oncology
Tight junctions (TJs) are large intercellular adhesion complexes that maintain cell polarity in normal epithelia and endothelia. Claudins are critical components of TJs, forming homo- and heteromeric interaction between adjacent cells, which have emerged
Benjamin Vonniessen, Benjamin Vonniessen, Sébastien Tabariès, Sébastien Tabariès, Peter M. Siegel, Peter M. Siegel, Peter M. Siegel, Peter M. Siegel, Peter M. Siegel   +8 more
doaj   +1 more source

Claudins and mineral metabolism [PDF]

Current Opinion in Nephrology and Hypertension, 2016
The tight junction conductance made of the claudin-based paracellular channel is important in the regulation of calcium and magnesium reabsorption in the kidney. This review describes recent findings of the structure, the function, and the physiologic regulation of claudin-14, claudin-16, and claudin-19 channels that through protein interactions confer
openaire   +2 more sources