Results 31 to 40 of about 14,885 (290)

Claudin Family Participates in the Pathogenesis of Inflammatory Bowel Diseases and Colitis-Associated Colorectal Cancer

Frontiers in Immunology, 2019
Claudins are a multigene transmembrane protein family comprising at least 27 members. In gastrointestinal tract, claudins are mainly located in the intestinal epithelia; many types of claudins form a network of strands in tight junction plaques within ...
Liguo Zhu, Jing Han, Li Li, Ying Wang, Ying Li, Shenghong Zhang   +5 more
doaj   +1 more source

Tight Junction Claudins and Occludin Are Differentially Regulated and Expressed in Genomically Defined Subsets of Colon Cancer

Current Issues in Molecular Biology, 2023
Metastatic colon cancer remains incurable despite improvements in survival outcomes. New therapies based on the discovery of colon cancer genomic subsets could improve outcomes.
Ioannis A. Voutsadakis
doaj   +1 more source

Biology of claudins

American Journal of Physiology-Renal Physiology, 2008
Claudins are a family of tight junction membrane proteins that regulate paracellular permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are expressed throughout the renal tubule, and mutations in two claudin genes are now known to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review,
Susanne, Angelow, Robert, Ahlstrom, Alan S L, Yu   +2 more
openaire   +3 more sources

Claudin and pancreatic cancer

Frontiers in Oncology, 2023
Due to the lack of timely and accurate screening modalities and treatments, most pancreatic cancer (PCa) patients undergo fatal PCa progression within a short period since diagnosis. The claudin(CLDN) family is expressed specifically as tight junction structure in a variety of tumors, including PCa, and affects tumor progression by changing the cell ...
Chen Wang, Chen Wang, Na Wu, Beibei Pei, Xiaoyan Ma, Wenhui Yang   +5 more
openaire   +3 more sources

Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients

Frontiers in Oncology, 2020
High-grade serous ovarian carcinoma (HGSOC) usually spreads directly into the peritoneal cavity following a transcoelomic dissemination route, although distant hematogenous metastasis exist and have been reported.
Chiara Romani, Chiara Romani, Valentina Zizioli, Marco Silvestri, Marco Silvestri, Laura Ardighieri, Mattia Bugatti, Michela Corsini, Paola Todeschini, Sergio Marchini, Maurizio D'Incalci, Laura Zanotti, Antonella Ravaggi, Antonella Ravaggi, Antonella Ravaggi, Fabio Facchetti, Angela Gambino, Angela Gambino, Franco Odicino, Franco Odicino, Enrico Sartori, Enrico Sartori, Alessandro Davide Santin, Stefania Mitola, Eliana Bignotti, Eliana Bignotti, Stefano Calza, Stefano Calza   +27 more
doaj   +1 more source

Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.

PLoS ONE, 2017
Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability.
Shinsaku Tokuda, Toyohiro Hirai, Mikio Furuse   +2 more
doaj   +1 more source

Claudins and Regulation of the Paracellular Transport System [PDF]

, 2006
Epithelia create barriers and regulate solute and water transport through transcellular and paracellular pathways. The paracellular pathways of different tissues vary remarkably in size selectivity, ionic charge selectivity and transepithelial electrical
Rasmussen, Julia E.
core   +1 more source

Functional Analysis of Gastric Tight Junction Proteins in Xenopus laevis Oocytes

Membranes, 2022
The epithelial barrier is crucial for proper gastrointestinal function, preventing the unwanted passage of solutes and therefore representing a prerequisite for vectorial transport.
Laura Stein, Nora Brunner, Salah Amasheh
doaj   +1 more source

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Food & Nutrition Research, 2022
Background: Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells.
Hui-Xin Zhang, Ye-Ye Li, Zhong-Jie Liu, Jiu-Feng Wang   +3 more
doaj   +1 more source

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux [PDF]

, 2022
The paracellular passage of ions and small molecules across epithelia is controlled by tight junctions, complex meshworks of claudin polymers that form tight seals between neighboring cells.
Furuse, Mikio, Günzel, Dorothee, Van der Veen, Rozemarijn Eva, Gonschior, Hannes, Schmied, Christopher, Eichhorst, Jenny, Himmerkus, Nina, Bleich, Markus, Haucke, Volker, Lehmann, Martin, Piontek, Jörg   +10 more
core   +1 more source