Results 11 to 20 of about 14,180 (293)
NLRs Challenge Impacts Tight Junction Claudins In Sertoli Cells
Folia Medica, 2015 Aim: The present study aims to investigate the NALP3 system and its effect on claudins in Sertoli cells using a mouse adult Sertoli cell line as a model.
Hayrabedyan Soren B. +2 more
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Context-Dependent Roles of Claudins in Tumorigenesis
Frontiers in Oncology, 2021 The barrier and fence functions of the claudin protein family are fundamental to tissue integrity and human health. Increasing evidence has linked claudins to signal transduction and tumorigenesis. The expression of claudins is frequently dysregulated in
Jian Li
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Genome Biology, 2009 The claudin multigene family encodes tetraspan membrane proteins that are crucial structural and functional components of tight junctions, which have important roles in regulating paracellular permeability and maintaining cell polarity in epithelial and endothelial cell sheets.
Lal-Nag, Madhu, Morin, Patrice J
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Informatics in Medicine Unlocked, 2022 Claudins are a class of transmembrane proteins in the family of tight junction (TJ) proteins. The disrupted functioning of claudins has been found to have a role in urolithiasis (Kidney stones).
Anirudh Gururaj Patil +4 more
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Annual Review of Physiology, 2013 Claudins are tight junction membrane proteins that regulate paracellular permeability of renal epithelia to small ions, solutes, and water. Claudins interact within the cell membrane and between neighboring cells to form tight junction strands and constitute both the paracellular barrier and the pore.
Jianghui, Hou +2 more
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Cells, 2022 Claudins are a family of integral membrane proteins that enable epithelial cell/cell interactions by localizing to and driving the formation of tight junctions.
Chinemerem P. Ogbu +2 more
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SUMOylation of claudin‐2 [PDF]
Annals of the New York Academy of Sciences, 2012 The C‐terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two‐hybrid screen with the tail of human claudin‐2 against a human kidney cDNA library and identified interactions with the PDZ3 domain of ZO‐2 as well as ubiquitin‐conjugating enzyme E2I (SUMO ligase‐1) and E3 ...
Christina M, Van Itallie +2 more
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The role and mechanism of claudins in cancer
Frontiers in Oncology, 2022 Claudins are a tetraspan membrane protein multigene family that plays a structural and functional role in constructing tight junctions. Claudins perform crucial roles in maintaining cell polarity in epithelial and endothelial cell sheets and controlling ...
De-Wen Wang +10 more
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Role of Stress on Driving the Intestinal Paracellular Permeability
Current Issues in Molecular Biology, 2023 The gut epithelium is a polarized monolayer that exhibits apical and basolateral membrane surfaces. Monolayer cell components are joined side by side via protein complexes known as tight junction proteins (TJPs), expressed at the most apical extreme of ...
Daniel Efrain Molotla-Torres +3 more
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Pharmaceutics, 2023 Claudins regulate paracellular permeability, contribute to epithelial polarization and are dysregulated during inflammation and carcinogenesis. Variants of the claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) are highly sensitive ...
Ayk Waldow +13 more
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