Results 1 to 10 of about 79,602 (359)
Frontiers in Oncology, 2023 Due to the lack of timely and accurate screening modalities and treatments, most pancreatic cancer (PCa) patients undergo fatal PCa progression within a short period since diagnosis.
Chen Wang +4 more
semanticscholar +4 more sources
Frontiers in Immunology, 2019 Claudins are a multigene transmembrane protein family comprising at least 27 members. In gastrointestinal tract, claudins are mainly located in the intestinal epithelia; many types of claudins form a network of strands in tight junction plaques within ...
Liguo Zhu +5 more
doaj +2 more sources
Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function
Nature Communications, 2023 Claudin family tight junction proteins form charge- and size-selective paracellular channels that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is attributed to differential claudin expression.
Arturo Raya-Sandino +10 more
semanticscholar +1 more source
Scientific Reports, 2023 Claudin 18.2 has emerged as a promising therapeutic target in gastric cancer based on phase 3 studies. However, clinicopathologic features associated with claudin 18.2 overexpression have not been comprehensively studied specifically for patients with ...
Hyung-Don Kim +6 more
semanticscholar +1 more source
Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis
International Journal of Molecular Sciences, 2023 Inflammatory bowel diseases (IBDs) are characterized by acute or chronic recurring inflammation of the intestinal mucosa, often with increasing severity over time. Life-long morbidities and diminishing quality of life for IBD patients compel a search for
C. Capaldo
semanticscholar +1 more source
Biomedicines, 2023 (1) Introduction: Claudin-9 (CLDN9) is a member of the claudin protein family, a critical transmembrane protein family for tight junctions that are implemented in the progression of numerous cancer types.
Xinguo Zhuang +8 more
doaj +1 more source
Tissue Barriers, 2021 Claudins are major components of tight junctions that maintain cell polarity and intercellular adhesion. The dynamics of claudins in cancer cells have attracted attention as a therapeutic target.
D. Kyuno +8 more
semanticscholar +1 more source
Polish Journal of Pathology, 2022 We investigated the expression of claudin 6 in non-small-cell lung carcinomas (NSCLC) by immunohistochemistry. Samples of 164 patients with NSCLC were studied by immunohistochemistry. Claudin 6 was expressed in 42 % of cases.
Ylermi Soini +4 more
doaj +1 more source
Toxins, 2023 Background: Clostridioides difficile binary toxin (CDT) defines the hypervirulence of strains in nosocomial antibiotic-induced colitis with the highest mortality.
Lucas Heils +4 more
doaj +1 more source
Mucosal Immunology, 2022 Tight junctions are essential for barrier integrity, inflammation, and cancer. Vitamin D and the vitamin D receptor (VDR) play important roles in colorectal cancer (CRC).
Yongguo Zhang +4 more
semanticscholar +1 more source