Results 11 to 20 of about 79,602 (359)
Claudin-1, A Double-Edged Sword in Cancer [PDF]
International Journal of Molecular Sciences, 2020 Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated and studied in a multitude of ...
A. Bhat +17 more
semanticscholar +2 more sources
Structure-forward targeting of claudins with synthetic binders. [PDF]
FEBS LettClaudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Vecchio AJ.
europepmc +2 more sources
Claudin-3-deficient C57BL/6J mice display intact brain barriers [PDF]
Scientific Reports, 2019 The tight junction protein claudin-3 has been identified as a transcriptional target of the Wnt/β-catenin signaling pathway regulating blood-brain barrier (BBB) maturation.
Mariana Castro Dias +18 more
semanticscholar +3 more sources
Genome Biology, 2009 The claudin multigene family encodes tetraspan membrane proteins that are crucial structural and functional components of tight junctions, which have important roles in regulating paracellular permeability and maintaining cell polarity in epithelial and endothelial cell sheets.
Lal-Nag, Madhu, Morin, Patrice J
openaire +2 more sources
Annual Review of Physiology, 2013 Claudins are tight junction membrane proteins that regulate paracellular permeability of renal epithelia to small ions, solutes, and water. Claudins interact within the cell membrane and between neighboring cells to form tight junction strands and constitute both the paracellular barrier and the pore.
Jianghui, Hou +2 more
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Context-Dependent Roles of Claudins in Tumorigenesis
Frontiers in Oncology, 2021 The barrier and fence functions of the claudin protein family are fundamental to tissue integrity and human health. Increasing evidence has linked claudins to signal transduction and tumorigenesis. The expression of claudins is frequently dysregulated in
Jian Li
doaj +1 more source
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels
Biology, 2021 Simple Summary The influence of Short-chain fatty acids (SCFAs) on barrier function under pathological conditions has not been assessed, and the regulation of the tight junction (TJ) proteins by SCFAs under pathological conditions has not been fully ...
Xinyi Huang +4 more
semanticscholar +1 more source
Human Claudin-7 cis-Interactions Are Not Crucial for Membrane-Membrane (Trans-) Interactions
Frontiers in Molecular Biosciences, 2022 Human Claudin-7 (Cldn7) is a member of the Claudin (Cldn) superfamily. In vivo, these proteins form tight junctions, which establish constricted connections between cells. Cldns oligomerize within the membrane plane (= cis-interaction), and also interact
Lena Ahlswede +5 more
doaj +1 more source
Cation and water channel properties of claudin-2 co-expressed with claudin-1 or claudin-3
CATION AND WATER CHANNEL PROPERTIES OF CLAUDIN-2 CO-EXPRESSED WITH CLAUDIN-1 OR CLAUDIN-3 Cation and water channel properties of claudin-2 co-expressed with claudin-1 or claudin-3 / Martinez Perafan, Fabian Humberto (Rights reserved) (-
Martinez Perafan, Fabian Humberto
core +2 more sources
Physiological Reports, 2023 Using the 16HBE 14o‐ human airway epithelial cell culture model, calcitriol (Vitamin D) was shown to improve barrier function by two independent metrics – increased transepithelial electrical resistance (TER) and reduced transepithelial diffusion of 14C ...
Elizabeth Rybakovsky +6 more
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