Results 41 to 50 of about 79,602 (359)

Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells

Frontiers in Pharmacology, 2023
The oleoresin myrrh has been used for centuries as an anti-inflammatory remedy for a variety of diseases and is said to have a protective effect on the intestinal epithelium.
Helena Hader, Nina A. Hering, Jörg-Dieter Schulzke, Roland Bücker, Rita Rosenthal   +4 more
doaj   +1 more source

Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier.

Biological and Pharmaceutical Bulletin, 2021
Claudin-5 is the dominant tight junction protein in brain endothelial cells and exclusively limits the paracellular permeability of molecules larger than 400 Da across the blood-brain barrier (BBB).
Y. Hashimoto, M. Campbell, K. Tachibana, Yoshiaki Okada, M. Kondoh   +4 more
semanticscholar   +1 more source

The Expression and Localization of ZO-1, Claudin 1, and Claudin 4 in the Pig Epididymis

Journal of Animal Reproduction and Biotechnology, 2019
Tight junctions are constituents of the blood–epididymis barrier that play roles in regulating the unidirectional transcellular transport of ions, water, and solutes to maintain optimal conditions for sperm maturation and storage. Claudin 1 (Cldn1) and 4
Yun-Jae Park, Bongki Kim
doaj   +1 more source

Identification of key claudin genes associated with survival prognosis and diagnosis in colon cancer through integrated bioinformatic analysis

Frontiers in Genetics, 2023
The claudin multigene family is associated with various aberrant physiological and cellular signaling pathways. However, the association of claudins with survival prognosis, signaling pathways, and diagnostic efficacy in colon cancer remains poorly ...
Rana A. Alghamdi, Rana A. Alghamdi, Maryam H. Al-Zahrani   +2 more
doaj   +1 more source

Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the BloodBrain Barrier

, 2021
Aging-induced alterations to the blood–brain barrier (BBB) are increasingly being seen as a primary event in chronic progressive neurological disorders that lead to cognitive decline.
Alex Vecchio, Saiprasad Gowrikumar (5581430), Forrest M. Kievit (1341276), Punita Dhawan (158034), Forrest M. Kievit, Connor C. Gee, Punita Dhawan, Sourav Roy, Evan T. Curtis (11663911), Hunter A. Miller, Saiprasad Gowrikumar, Badrul Alam Bony (11663902), Aria W. Tarudji, Connor C. Gee (11663914), Sourav Roy (389598), Hunter A. Miller (11663908), Alex Vecchio (11663917), Badrul Alam Bony, Evan T. Curtis, Aria W. Tarudji (11663905)   +19 more
core   +1 more source

The role and mechanism of claudins in cancer

Frontiers in Oncology, 2022
Claudins are a tetraspan membrane protein multigene family that plays a structural and functional role in constructing tight junctions. Claudins perform crucial roles in maintaining cell polarity in epithelial and endothelial cell sheets and controlling ...
De-Wen Wang, De-Wen Wang, Wei-Han Zhang, Wei-Han Zhang, Galiullin Danil, Galiullin Danil, Galiullin Danil, Kun Yang, Kun Yang, Jian-Kun Hu, Jian-Kun Hu   +10 more
doaj   +1 more source

Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review

Pharmaceutics, 2020
The blood-brain barrier (BBB), which is composed of endothelial cells, pericytes, astrocytes, and neurons, separates the brain extracellular fluid from the circulating blood, and maintains the homeostasis of the central nervous system (CNS).
Keisuke Tachibana, Yumi Iwashita, Erika Wakayama, Itsuki Nishino, Taiki Nishikaji, Masuo Kondoh   +5 more
doaj   +1 more source

Microbial-derived Butyrate Promotes Epithelial Barrier Function Through IL-10 Receptor-dependent Repression of Claudin-2

Journal of Immunology, 2017
Commensal interactions between the enteric microbiota and distal intestine play important roles in regulating human health. Short-chain fatty acids (SCFAs), such as butyrate, produced through anaerobic microbial metabolism represent a major energy source
Leon Zheng, Caleb J. Kelly, Kayla D. Battista, Rachel E. M. Schaefer, Jordi M. Lanis, Erica E. Alexeev, Ruth X. Wang, Joseph C. Onyiah, D. Kominsky, S. Colgan   +9 more
semanticscholar   +1 more source

cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids

Pharmaceutics, 2023
Claudins regulate paracellular permeability, contribute to epithelial polarization and are dysregulated during inflammation and carcinogenesis. Variants of the claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) are highly sensitive ...
Ayk Waldow, Laura-Sophie Beier, Janine Arndt, Simon Schallenberg, Claudia Vollbrecht, Philip Bischoff, Martí Farrera-Sal, Florian N. Loch, Christian Bojarski, Michael Schumann, Lars Winkler, Carsten Kamphues, Lukas Ehlen, Jörg Piontek   +13 more
doaj   +1 more source

Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors [PDF]

, 2010
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined.
Christiane Brohm, Kathrin Hueging, Michael Ott, Hueging, Kathrin, Brohm, Christiane, Ott, Michael, Bitzegeio, Julia, Dorothea Bankwitz, Herrmann, Eva, Sibylle Haid, Thomas Pietschmann, Mirjam B. Zeisel, Baumert, Thomas F, Iken, Marcus, Haid, Sibylle, Marcus Iken, Julia Bitzegeio, Thomas F. Baumert, Zeisel, Mirjam B, Thomas F Baumert, Mirjam B Zeisel, Eva Herrmann, Baumert, Thomas, Bankwitz, Dorothea, Zeisel, Mirjam B., Pietschmann, Thomas   +25 more
core   +2 more sources