Results 61 to 70 of about 56,637 (316)
Claudin-1 protein expression levels determined by western blot.
, 2016 The relative folds changes of Claudin-1 in the SO, CPB, MHCA and DHCA groups were 1.000 ± 0.130, 0.992 ± 0.069, 0.956 ± 0.062 and 0.784 ± 0.054, respectively. Mean ± SD; n = 5. **P < 0.05 DHCA vs. CPB; ^ P < 0.05 DHCA vs. MHCA.
Mengya Liang (3186129) +7 more
core +1 more source
Advanced Science, EarlyView.Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang +10 more
wiley +1 more source
Cells, 2022 Cryptorchidism, a condition in which testes fail to descend from the abdomen into the scrotum, is a risk factor for infertility and germ cell cancer. Normally, tight junctions between adjacent Sertoli cells in the testes form a blood–testes barrier that ...
Hyunjhung Jhun +4 more
doaj +1 more source
Claudins and gastric carcinogenesis
Experimental Biology and Medicine, 2013 Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight ...
Omid, Iravani +4 more
openaire +2 more sources
Claudin-1 localisation at the tight junctions is disrupted by PAF and restored by BML-111.
, 2023 Composite X/Y confocal images of 16HBE14o- polarised monolayers untreated (control) or treated with P. aeruginosa filtrate (PAF) for 24h or PAF + 200 nmol/L BML-111 (BML) immunostained for (A) ZO-1 (red), (B) Claudin-1 (red), (C) E-cadherin (red). Nuclei
Sonya Jackson (3179151) +2 more
core +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Advanced Science, EarlyView.Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk +9 more
wiley +1 more source
La Revolución Pictórica de Nuestro Tiempo.
La Universidad, 2018 La Revolución Pictórica de Nuestro Tiempo.
Fernando Claudín
doaj
The Expression of the Claudin Family of Proteins in Colorectal Cancer
BiomoleculesClaudins (CLDN1–CLDN24) are a family of tight junction proteins whose dysregulation has been implicated in tumorigeneses of many cancer types. In colorectal cancer (CRC), CLDN1, CLDN2, CLDN4, and CLDN18 have been shown to either be upregulated or ...
Kristin E. Cox +5 more
doaj +1 more source
Localization of Claudin‐3 and Claudin‐4 within the Small Intestine of newborn piglets
Physiological Reports, 2021 Piglets must acquire passive immunity through colostrum within hours after birth to survive. How colostral macromolecules traverse the small intestinal epithelium may include nonselective pinocytosis and paracellular transport through tight junction ...
Brodie Deluco +3 more
doaj +1 more source