Results 71 to 80 of about 79,602 (359)

All about claudins [PDF]

Tissue Barriers, 2013
Since the discovery of Claudins more than a decade ago, much has been learned about their structure-function relationships. Claudins are tetraspan membrane proteins responsible for the formation of tight junctions. In this capacity, Claudins form a tissue-specific selective permeability barrier that is critical for the function of the tissue.
openaire   +2 more sources

Claudin-16 and claudin-19 function in the thick ascending limb [PDF]

Current Opinion in Nephrology and Hypertension, 2010
Claudin-16 and claudin-19 play a major role in the regulation of magnesium reabsorption in the thick ascending limb (TAL). This review describes recent findings of the physiological function of claudin-16 and claudin-19 underlying normal transport function for magnesium reabsorption in the TAL.Mutations in the genes encoding the tight junction proteins
Jianghui, Hou, Daniel A, Goodenough
openaire   +2 more sources

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

eLife, 2020
Diabetes mellitus is a known susceptibility factor for severe influenza virus infections. However, the mechanisms that underlie this susceptibility remain incompletely understood.
Katina D Hulme, Limin Yan, Rebecca J Marshall, Conor J Bloxham, Kyle R Upton, Sumaira Z Hasnain, Helle Bielefeldt-Ohmann, Zhixuan Loh, Katharina Ronacher, Keng Yih Chew, Linda A Gallo, Kirsty R Short   +11 more
doaj   +1 more source

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Journal of Cell Biology, 1998
Occludin is the only known integral membrane protein localizing at tight junctions (TJ), but recent targeted disruption analysis of the occludin gene indicated the existence of as yet unidentified integral membrane proteins in TJ.
M. Furuse, Kohji Fujita, T. Hiiragi, K. Fujimoto, S. Tsukita   +4 more
semanticscholar   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Early Radiation-Induced Changes in Lung Tissue and Intercellular Junctions: Implications for Tissue Repair and Fibrosis

Pathophysiology
Early changes in lung tissue following ionizing radiation (IR) initiate processes that may lead to either regeneration or fibrosis. Intercellular junction proteins play a crucial role in the organization and function of epithelial tissues, both under ...
Ekaterina S. Karetnikova, Alexandra A. Livanova, Arina A. Fedorova, Alexander G. Markov   +3 more
doaj   +1 more source

Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy

Frontiers in Immunology, 2022
BackgroundIn bladder and breast cancer, the claudin-low subtype is widely identified, revealing a distinct tumor microenvironment (TME) and immunological feature.
Cuijian Zhang, Cuijian Zhang, Cuijian Zhang, Yifan Li, Yifan Li, Yifan Li, Jinqin Qian, Jinqin Qian, Jinqin Qian, Zhenpeng Zhu, Zhenpeng Zhu, Zhenpeng Zhu, Cong Huang, Cong Huang, Cong Huang, Zhisong He, Zhisong He, Zhisong He, Liqun Zhou, Liqun Zhou, Liqun Zhou, Yanqing Gong, Yanqing Gong, Yanqing Gong   +23 more
doaj   +1 more source

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Journal of Cell Biology, 2003
Tight junctions are well-developed between adjacent endothelial cells of blood vessels in the central nervous system, and play a central role in establishing the blood-brain barrier (BBB). Claudin-5 is a major cell adhesion molecule of tight junctions in
Takehiro Nitta, Masaki Hata, S. Gotoh, Yoshiteru Seo, H. Sasaki, N. Hashimoto, M. Furuse, S. Tsukita   +7 more
semanticscholar   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Transcriptomic Analysis of Testicular Gene Expression in a Dog Model of Experimentally Induced Cryptorchidism

Cells, 2022
Cryptorchidism, a condition in which testes fail to descend from the abdomen into the scrotum, is a risk factor for infertility and germ cell cancer. Normally, tight junctions between adjacent Sertoli cells in the testes form a blood–testes barrier that ...
Hyunjhung Jhun, Won-Young Lee, Jin-Ki Park, Sun-Goo Hwang, Hyun-Jung Park   +4 more
doaj   +1 more source