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Crypt-Level Tight Junction Remodeling Is Associated with Disease Course and Clinical Outcomes in Inflammatory Bowel Disease [PDF]

Cells
Background: Intestinal barrier dysfunction is a hallmark of inflammatory bowel disease (IBD), yet the clinical significance of tight junction (TJ) remodeling remains unclear.
Efthymios P. Tsounis, Christina Geramoutsou, Ploutarchos Pastras, Ioanna Aggeletopoulou, Pinelopi Bosgana, Theoni Lourida, Georgia Diamantopoulou, Sofia Ritsatou, Efthymios Koniaris, Gerassimos J. Mantzaris, Vasiliki Zolota, Stelios F. Assimakopoulos, Vasiliki Bravou, Konstantinos Thomopoulos, Georgios Theocharis, Christos Triantos   +15 more
doaj   +2 more sources

Molecular characterization, developmental expression, and modulation of occludin by early intervention with Clostridium butyricum in Muscovy ducks

Poultry Science, 2021
: Occludin is an important component of tight junction proteins and has been extensively studied in animals such as mice, chickens, geese, and pigs. As one of the most important waterfowl species in China, Muscovy duck (Cairina moschata) is an important ...
Hua Yang, Wentao Lyu, Yingping Xiao
exaly   +3 more sources

Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice

Frontiers in Endocrinology, 2022
Occludin (OCLN) is a tight junction protein and Ocln deletion mutation causes male infertility in mice. However, the role of OCLN in male reproductive system remains unknown.
Bao Ying Liu, Bao Ying Liu, Bao Ying Liu, Bao Li Zhang, Bao Li Zhang, Bao Li Zhang, Da Yuan Gao, Da Yuan Gao, Da Yuan Gao, Qing Li, Xin Yu Xu, Xin Yu Xu, Xin Yu Xu, Winnie Shum, Winnie Shum   +14 more
doaj   +1 more source

Tight Junction Claudins and Occludin Are Differentially Regulated and Expressed in Genomically Defined Subsets of Colon Cancer

Current Issues in Molecular Biology, 2023
Metastatic colon cancer remains incurable despite improvements in survival outcomes. New therapies based on the discovery of colon cancer genomic subsets could improve outcomes.
Ioannis A. Voutsadakis
doaj   +1 more source

CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

Toxins, 2023
Background: Clostridioides difficile binary toxin (CDT) defines the hypervirulence of strains in nosocomial antibiotic-induced colitis with the highest mortality.
Lucas Heils, Martina Schneemann, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker   +4 more
doaj   +1 more source

Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway

Frontiers in Cellular and Infection Microbiology, 2022
Tight junctions (TJs) are essential components of intestinal barrier integrity and protect the epithelium against passive paracellular flux and microbial translocation.
Sudha B. Singh, Cristina N. Coffman, Matthew G. Varga, Amanda Carroll-Portillo, Cody A. Braun, Henry C. Lin, Henry C. Lin   +6 more
doaj   +1 more source

Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Human intestinal epithelial cell line-6 (HIEC-6) cells and primary human hepatocytes (PHHs) were treated with 3-amidinophenylalanine-derived inhibitors of trypsin-like serine proteases for 24 hours.
Erzsébet Pászti-Gere, Judit Pomothy, Ákos Jerzsele, Oliver Pilgram, Torsten Steinmetzer   +4 more
doaj   +1 more source

Campylobacter jejuni Serine Protease HtrA Cleaves the Tight Junction Component Claudin-8

Frontiers in Cellular and Infection Microbiology, 2020
Campylobacter jejuni express the high temperature requirement protein A (HtrA), a secreted serine protease, which is implicated in virulence properties of the pathogen. Previous studies have shown that C.
Irshad Sharafutdinov, Delara Soltan Esmaeili, Aileen Harrer, Nicole Tegtmeyer, Heinrich Sticht, Steffen Backert   +5 more
doaj   +1 more source

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

Frontiers in Physiology, 2020
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding neurotoxic substances from the peripheral circulation.
Jeffrey J. Lochhead, Junzhi Yang, Patrick T. Ronaldson, Thomas P. Davis   +3 more
doaj   +1 more source

Effects of high incubation temperature on tight junction proteins in the yolk sac and small intestine of embryonic broilers

Poultry Science, 2023
: During the transition from incubation to hatch, the chicks shift from obtaining nutrients from the yolk sac to the intestine. The yolk sac tissue (YST) and small intestine serve as biological barriers between the yolk or gut contents and the blood ...
M. Jia, K.L. Reynolds, E.A. Wong
doaj   +1 more source