Results 1 to 10 of about 43,361 (299)

Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2 [PDF]

FEBS Letters, 2003
In epithelial and endothelial cells, tight junctions limit paracellular flux of ions, proteins and other macromolecules. However, mechanisms regulating tight junction function are not clear. Occludin, a tight junction protein, undergoes phosphorylation changes in several situations but little is known about occludin kinases.
Smales, Caroline, Ellis, Moira, Baumber, Rachel, Hussain, Nayer, Desmond, Howard, Staddon, James M   +5 more
openaire   +3 more sources

Phosphorylation of occludin correlates with occludin localization and function at the tight junction [PDF]

American Journal of Physiology-Cell Physiology, 1997
Multiple forms of occludin were found in Madin-Darby canine kidney (MDCK) cells. In the absence of cell-to-cell contacts, achieved by incubating cells in low-calcium growth medium, a cluster of lower-molecular-weight (LMW) occludin bands (∼65,000–68,000) was present in both MDCK I and II cells. On formation of tight junctions, achieved by changing the
Vivian Wong
openaire   +3 more sources

Crypt-Level Tight Junction Remodeling Is Associated with Disease Course and Clinical Outcomes in Inflammatory Bowel Disease [PDF]

Cells
Background: Intestinal barrier dysfunction is a hallmark of inflammatory bowel disease (IBD), yet the clinical significance of tight junction (TJ) remodeling remains unclear.
Efthymios P. Tsounis, Christina Geramoutsou, Ploutarchos Pastras, Ioanna Aggeletopoulou, Pinelopi Bosgana, Theoni Lourida, Georgia Diamantopoulou, Sofia Ritsatou, Efthymios Koniaris, Gerassimos J. Mantzaris, Vasiliki Zolota, Stelios F. Assimakopoulos, Vasiliki Bravou, Konstantinos Thomopoulos, Georgios Theocharis, Christos Triantos   +15 more
doaj   +2 more sources

Redox-sensitivity of the dimerization of occludin [PDF]

Cellular and Molecular Life Sciences, 2009
Occludin is a self-associating transmembrane tight junction protein affected in oxidative stress. However, its function is unknown. The cytosolic C-terminal tail contains a coiled coil-domain forming dimers contributing to the self-association. Studying the hypothesis that the self-association is redox-sensitive, we found that the dimerization of the ...
Walter, Juliane K., Castro, Victor Manuel, Voss, Martin, Gast, Klaus, Rueckert, Christine, Piontek, Jörg, Blasig, Ingolf E.   +6 more
core   +6 more sources

Evaluation of Serum Zonulin and Occludin Levels in Bipolar Disorder [PDF]

Psychiatry Investigation, 2023
Objective The etiology of bipolar disorder (BD) is still not fully understood. Little is currently known about the relationship between the interaction the gastrointestinal system and brain function and BD. Zonulin is the only known physiological modulator of tight junctions and is a biomarker for intestinal permeability (IP).
Sertaç Zengil, Esra Laloğlu
openaire   +5 more sources

Shear stress regulates occludin content and phosphorylation [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2001
Previous studies determined that shear stress imposed on bovine aortic endothelial cell (BAEC) monolayers increased the hydraulic conductivity ( LP); however, the mechanism by which shear stress increases LPremains unknown. This study tested the hypothesis that shear stress regulates paracellular transport by altering the expression and phosphorylation
L, DeMaio, Y S, Chang, T W, Gardner, J M, Tarbell, D A, Antonetti   +4 more
openaire   +3 more sources

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease [PDF]

Advanced Science
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract. This disease is characterized by a steadily increasing global incidence.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
doaj   +2 more sources

238. Claudins and occludin in the rat endometrium [PDF]

Reproduction, Fertility and Development, 2005
Regulation of the uterine luminal environment is important for the successful attachment and implantation of the blastocyst. Tight junctions regulate the paracellular pathway between epithelial cells lining the uterine lumen and the uterine glands.
M. D. O. Nicholson, C. R. Murphy
openaire   +2 more sources

Molecular characterization, developmental expression, and modulation of occludin by early intervention with Clostridium butyricum in Muscovy ducks

Poultry Science, 2021
: Occludin is an important component of tight junction proteins and has been extensively studied in animals such as mice, chickens, geese, and pigs. As one of the most important waterfowl species in China, Muscovy duck (Cairina moschata) is an important ...
Wentao Lyu, Hua Yang, Lizhi Lu
exaly   +3 more sources

New Postbiotic Derived from Sequential Fermentation of Two Lacticaseibacillus Strains Exerts Beneficial Effects on Epithelial Gut Barrier and Innate Immunity in Human Enterocytes [PDF]

Microorganisms
The efficacy of postbiotics varies significantly between different strains and preparation processes. We aimed at evaluating the effect of an innovative postbiotic product (iPB) generated through the sequential fermentation of Lacticaseibacillus ...
Franca Oglio, Alessia Cadavere, Monia De Aloe, Anna Lintura, Marco Michelini, Chiara Luongo, Serena Coppola, Alessandra Agizza, Erika Caldaria, Laura Carucci   +9 more
doaj   +2 more sources