Results 11 to 20 of about 46,424 (193)
Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2 [PDF]
FEBS Letters, 2003 In epithelial and endothelial cells, tight junctions limit paracellular flux of ions, proteins and other macromolecules. However, mechanisms regulating tight junction function are not clear. Occludin, a tight junction protein, undergoes phosphorylation changes in several situations but little is known about occludin kinases.
Smales, Caroline +5 more
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Redox-sensitivity of the dimerization of occludin
Cellular and Molecular Life Sciences, 2009 Occludin is a self-associating transmembrane tight junction protein affected in oxidative stress. However, its function is unknown. The cytosolic C-terminal tail contains a coiled coil-domain forming dimers contributing to the self-association. Studying the hypothesis that the self-association is redox-sensitive, we found that the dimerization of the ...
Walter, Juliane K. +6 more
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Phosphorylation of occludin correlates with occludin localization and function at the tight junction
American Journal of Physiology-Cell Physiology, 1997 Multiple forms of occludin were found in Madin-Darby canine kidney (MDCK) cells. In the absence of cell-to-cell contacts, achieved by incubating cells in low-calcium growth medium, a cluster of lower-molecular-weight (LMW) occludin bands (∼65,000–68,000) was present in both MDCK I and II cells. On formation of tight junctions, achieved by changing the
Vivian Wong
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Shear stress regulates occludin content and phosphorylation
American Journal of Physiology-Heart and Circulatory Physiology, 2001 Previous studies determined that shear stress imposed on bovine aortic endothelial cell (BAEC) monolayers increased the hydraulic conductivity ( LP); however, the mechanism by which shear stress increases LPremains unknown. This study tested the hypothesis that shear stress regulates paracellular transport by altering the expression and phosphorylation
L, DeMaio +4 more
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Evaluation of Serum Zonulin and Occludin Levels in Bipolar Disorder
Psychiatry Investigation, 2023 Objective The etiology of bipolar disorder (BD) is still not fully understood. Little is currently known about the relationship between the interaction the gastrointestinal system and brain function and BD. Zonulin is the only known physiological modulator of tight junctions and is a biomarker for intestinal permeability (IP).
Sertaç Zengil, Esra Laloğlu
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Analysis of occludin trafficking, demonstrating continuous endocytosis, degradation, recycling and biosynthetic secretory trafficking [PDF]
, 2014 Tight junctions (TJs) link adjacent cells and are critical for maintenance of apical-basolateral polarity in epithelial monolayers. The TJ protein occludin functions in disparate processes, including wound healing and Hepatitis C Virus infection.
Iqbal, Mudassar; id_orcid +4 more
core +13 more sources
238. Claudins and occludin in the rat endometrium
Reproduction, Fertility and Development, 2005 Regulation of the uterine luminal environment is important for the successful attachment and implantation of the blastocyst. Tight junctions regulate the paracellular pathway between epithelial cells lining the uterine lumen and the uterine glands.
M. D. O. Nicholson, C. R. Murphy
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Occludin 1B, a Variant of the Tight Junction Protein Occludin [PDF]
Molecular Biology of the Cell, 2000 Occludin and claudin are the major integral membrane components of the mammalian tight junction. Although more than 11 distinct claudins have been identified, only 1 occludin transcript has been reported thus far. Therefore, we searched by reverse transcription–PCR for occludin-related sequences in Madin–Darby canine kidney (MDCK) mRNA and identified a
Z, Muresan, D L, Paul, D A, Goodenough
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Occludin Modulates Transepithelial Migration of Neutrophils [PDF]
Journal of Biological Chemistry, 2000 Neutrophils cross epithelial sheets to reach inflamed mucosal surfaces by migrating along the paracellular route. To avoid breakdown of the epithelial barrier, this process requires coordinated opening and closing of tight junctions, the most apical intercellular junctions in epithelia. To determine the function of epithelial tight junction proteins in
Huber D, Balda MS, Matter K
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Low Expression of Occludin in the Melanoma Patient [PDF]
Iranian Journal of Pathology, 2019 Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in ...
Salehi, Pouri +2 more
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