Results 11 to 20 of about 43,361 (299)
Loss of occludin leads to the progression of human breast cancer [PDF]
International Journal of Molecular Medicine, 2010 Occludin is an integral membrane protein localised at tight junctions (TJs). It has become clear that the TJ is an important structure that cancer cells must overcome in order to metastasize successfully. The purpose of this study was to elucidate the importance of the expression of occludin in human breast cancer.
Martin, Tracey Amanda +2 more
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Frontiers in Endocrinology, 2022 Occludin (OCLN) is a tight junction protein and Ocln deletion mutation causes male infertility in mice. However, the role of OCLN in male reproductive system remains unknown.
Bao Ying Liu +14 more
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Current Issues in Molecular Biology, 2023 Metastatic colon cancer remains incurable despite improvements in survival outcomes. New therapies based on the discovery of colon cancer genomic subsets could improve outcomes.
Ioannis A. Voutsadakis
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Occludin 1B, a Variant of the Tight Junction Protein Occludin [PDF]
Molecular Biology of the Cell, 2000 Occludin and claudin are the major integral membrane components of the mammalian tight junction. Although more than 11 distinct claudins have been identified, only 1 occludin transcript has been reported thus far. Therefore, we searched by reverse transcription–PCR for occludin-related sequences in Madin–Darby canine kidney (MDCK) mRNA and identified a
Z, Muresan, D L, Paul, D A, Goodenough
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Toxins, 2023 Background: Clostridioides difficile binary toxin (CDT) defines the hypervirulence of strains in nosocomial antibiotic-induced colitis with the highest mortality.
Lucas Heils +4 more
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Frontiers in Cellular and Infection Microbiology, 2022 Tight junctions (TJs) are essential components of intestinal barrier integrity and protect the epithelium against passive paracellular flux and microbial translocation.
Sudha B. Singh +6 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Human intestinal epithelial cell line-6 (HIEC-6) cells and primary human hepatocytes (PHHs) were treated with 3-amidinophenylalanine-derived inhibitors of trypsin-like serine proteases for 24 hours.
Erzsébet Pászti-Gere +4 more
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Campylobacter jejuni Serine Protease HtrA Cleaves the Tight Junction Component Claudin-8
Frontiers in Cellular and Infection Microbiology, 2020 Campylobacter jejuni express the high temperature requirement protein A (HtrA), a secreted serine protease, which is implicated in virulence properties of the pathogen. Previous studies have shown that C.
Irshad Sharafutdinov +5 more
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Low Expression of Occludin in the Melanoma Patient [PDF]
Iranian Journal of Pathology, 2019 Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in ...
Salehi, Pouri +2 more
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Occludin immunolocalization and protein expression in goldfish [PDF]
Journal of Experimental Biology, 2008 SUMMARYTight junctions (TJs) are an integral component of models illustrating ion transport mechanisms across fish epithelia; however, little is known about TJ proteins in fishes. Using immunohistochemical methods and Western blot analysis, we examined the localization and expression of occludin, a transmembrane TJ protein, in goldfish tissues.
Helen, Chasiotis, Scott P, Kelly
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