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Frontiers in PhysiologyGut serves as the largest interface between humans and the environment, playing a crucial role in nutrient absorption and protection against harmful substances. The intestinal barrier acts as the initial defense mechanism against non-specific infections,
Hong-Yun Nie +14 more
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The Compromised Intestinal Barrier Induced by Mycotoxins
Toxins, 2020 Mycotoxins are fungal metabolites that occur in human foods and animal feeds, potentially threatening human and animal health. The intestine is considered as the first barrier against these external contaminants, and it consists of interconnected ...
Yanan Gao +4 more
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Intestinal Barrier, Claudins and Mycotoxins [PDF]
Toxins, 2021 The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact both on human and animal health.
Marta Justyna Kozieł +2 more
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Carotenoid metabolism at the intestinal barrier [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2020 Carotenoids exert a rich variety of physiological functions in mammals and are beneficial for human health. These lipids are acquired from the diet and metabolized to apocarotenoids, including retinoids (vitamin A and its metabolites). The small intestine is a major site for their absorption and bioconversion.
Johannes, von Lintig +3 more
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Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression [PDF]
Nutrients, 2021 The intestinal microbiota plays an important role in the pathophysiology of depression. As determined, the microbiota influences the shaping and modulation of the functioning of the gut–brain axis. The intestinal microbiota has a significant impact on processes related to neurotransmitter synthesis, the myelination of neurons in the prefrontal cortex ...
Paulina Trzeciak, Mariola Herbet
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Journal of Immunology Research, 2022 Objectives. Intestinal epithelial barrier function is an important mechanical barrier to maintain intestinal homeostasis and resist the invasion of intestinal pathogens and microorganisms.
Yuejin Li +7 more
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Pharmacological Research, 2023 Succinate is a vital signaling metabolite produced by the host and gut microbiota. Succinate has been shown to regulate host metabolic homeostasis and inhibit obesity-associated inflammation in macrophages by engaging its cognate receptor, SUCNR1 ...
Xuan Li +6 more
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Particle and Fibre Toxicology, 2020 Background In food toxicology, there is growing interest in studying the impacts of foodborne nanoparticles (NPs, originating from food additives, food supplements or food packaging) on the intestinal microbiome due to the important and complex ...
Bruno Lamas +2 more
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The Role of Long Noncoding RNAs in Intestinal Health and Diseases: A Focus on the Intestinal Barrier
Biomolecules, 2023 The gut is the body’s largest immune organ, and the intestinal barrier prevents harmful substances such as bacteria and toxins from passing through the gastrointestinal mucosa.
Qianying Lu +5 more
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Helminths and intestinal barrier function [PDF]
Tissue Barriers, 2017 Approximately one-sixth of the worlds' population is infected with helminths and this class of parasite takes a major toll on domestic livestock. The majority of species of parasitic helminth that infect mammals live in the gut (the only niche for tapeworms) where they contact the hosts' epithelial cells.
Derek M, McKay +2 more
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