Results 1 to 10 of about 202,289 (117)

IL-1β and the Intestinal Epithelial Tight Junction Barrier

Frontiers in Immunology, 2021
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation.
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma   +2 more
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The Compromised Intestinal Barrier Induced by Mycotoxins

Toxins, 2020
Mycotoxins are fungal metabolites that occur in human foods and animal feeds, potentially threatening human and animal health. The intestine is considered as the first barrier against these external contaminants, and it consists of interconnected ...
Yanan Gao, Lu Meng, Huimin Liu, Jiaqi Wang, Nan Zheng   +4 more
doaj   +3 more sources

Role of Autophagy Inducers and Inhibitors in Intestinal Barrier Injury Induced by Intestinal Ischemia–Reperfusion (I/R)

Journal of Immunology Research, 2022
Objectives. Intestinal epithelial barrier function is an important mechanical barrier to maintain intestinal homeostasis and resist the invasion of intestinal pathogens and microorganisms.
Yuejin Li, Peng Zhang, Jian Zhang, Weimin Bao, Jinyuan Li, Yan Wei, Jinchao Ni, Kunmei Gong   +7 more
doaj   +1 more source

Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction

Pharmacological Research, 2023
Succinate is a vital signaling metabolite produced by the host and gut microbiota. Succinate has been shown to regulate host metabolic homeostasis and inhibit obesity-associated inflammation in macrophages by engaging its cognate receptor, SUCNR1 ...
Xuan Li, Guowen Huang, Yanan Zhang, Yuting Ren, Ruofan Zhang, Weiyun Zhu, Kaifan Yu   +6 more
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Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health

Particle and Fibre Toxicology, 2020
Background In food toxicology, there is growing interest in studying the impacts of foodborne nanoparticles (NPs, originating from food additives, food supplements or food packaging) on the intestinal microbiome due to the important and complex ...
Bruno Lamas, Natalia Martins Breyner, Eric Houdeau   +2 more
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The Role of Long Noncoding RNAs in Intestinal Health and Diseases: A Focus on the Intestinal Barrier

Biomolecules, 2023
The gut is the body’s largest immune organ, and the intestinal barrier prevents harmful substances such as bacteria and toxins from passing through the gastrointestinal mucosa.
Qianying Lu, Yangfan Liang, Xiangyan Meng, Yanmei Zhao, Haojun Fan, Shike Hou   +5 more
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Advances in Nanomedicines for Interaction with the Intestinal Barrier

Advanced NanoBiomed Research, 2022
The intestinal barrier plays a vital role in maintaining the homeostasis of the gut and the organism. Various nanomedicines with advantages in interacting with the intestinal barrier have been developed for disease treatment.
Sisi Lin, Feng Wu, Zhenping Cao, Jinyao Liu   +3 more
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Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling

Microbiome, 2023
Background The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function.
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan   +5 more
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Impact of selected nutritional components and lifestyle on human intestinal barrier function

Medycyna Ogólna i Nauki o Zdrowiu, 2021
Introduction and objective Intestinal barrier dysfunction may promote increased migration of antigens, bacteria and toxins from the intestinal lumen into the bloodstream.
Michał Andrulewicz
doaj   +1 more source

Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Frontiers in Pharmacology, 2020
Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a
Randong Yang, Xiaoxiao Hu, Xianzheng Xie, Haiqiong Chen, Huangyi Fang, Libing Zhu, Zhongrong Li   +6 more
doaj   +1 more source