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Intestinal Absorption Study: Challenges and Absorption Enhancement Strategies in Improving Oral Drug Delivery [PDF]
Pharmaceuticals, 2022 The oral route is the most common and practical means of drug administration, particularly from a patient’s perspective. However, the pharmacokinetic profile of oral drugs depends on the rate of drug absorption through the intestinal wall before entering
Mohd Faiz Mustaffa +2 more
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Simultaneous Prediction Method for Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System [PDF]
Pharmaceutics, 2023 Many evaluation tools for predicting human absorption are well-known for using cultured cell lines such as Caco-2, MDCK, and so on. Since the combinatorial chemistry and high throughput screening system, pharmacological assay, and pharmaceutical ...
Satoshi Kondo, Masateru Miyake
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Intestinal Absorption of Fructose [PDF]
Annual Review of Nutrition, 2018 Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases.
Ronaldo P, Ferraris +2 more
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Journal of Nanobiotechnology, 2021 Background The use of drug nanocarriers to encapsulate drugs for oral administration may become an important strategy in addressing the challenging oral absorption of some drugs.
Shiqi Guo +7 more
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A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models
Nutrients, 2020 Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution.
Hajo Haase, Maria Maares
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Glyceroniosomes for enhanced intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination [PDF]
Scientific ReportsThe objective was to investigate the effect of co-administration of hydrochlorothiazide and lisinopril as fixed dose combination on their intestinal absorption. The scope was extended to enhance intestinal absorption of both drugs.
Aya R. Elbasuony +3 more
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Pharmaceutics, 2019 The main objective of this review is to discuss recent advancements in the overall investigation and in vivo prediction of drug absorption. The intestinal permeability of an orally administered drug (given the value Peff) has been widely used to ...
Hans Lennernäs, David Dahlgren
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Journal of Lipid Research, 1964 Great progress in understanding the mechanisms of fat absorption by the mammalian intestine has been made in the past decade and a half. In contrast to the contentions of rival theorists of the century before this, it has been possible for many ...
John R. Senior
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Intestinal Absorption and Factors Influencing Bioavailability of Magnesium- An Update
Current Nutrition and Food Science, 2017 Background: Information on the bioavailability of the essential mineral Mg2+ is sparse. Objective/Method: Evaluation of the present knowledge on factors influencing the bioavailability and intestinal absorption of Mg2+.
Andreas Hahn, Jan Philipp Schuchardt
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The Intestinal Absorption of Folates [PDF]
Annual Review of Physiology, 2014 The properties of intestinal folate absorption were documented decades ago. However, it was only recently that the proton-coupled folate transporter (PCFT) was identified and its critical role in folate transport across the apical brush-border membrane of the proximal small intestine established by the loss-of-function mutations identified in the PCFT
Michele Visentin +2 more
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