Results 1 to 10 of about 9,057 (116)

Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method [PDF]

Brazilian Journal of Medical and Biological Research, 2017
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study
Y.-H. Wang, X.-M. Ke, C.-H. Zhang, R.-P. Yang   +3 more
doaj   +2 more sources

Enhanced Oral Bioavailability and Pharmacokinetics of Altrenogest via a Self-Nanoemulsifying Drug Delivery System [PDF]

Pharmaceutics
Background: Altrenogest (ALT) is a synthetic progestogen used to synchronize the oestrus of swine and horses. It is poorly absorbed orally and this severely limits its use.
Yixing Chen, Jing Li, Nanxin Li, Awn Abbas, Xiaoyang Ai, Zhirong Zhang, Wei Zhang, Hualin Fu   +7 more
doaj   +2 more sources

L-Arginine as an Adjuvant Chemosensitizer: Enhancement of Intestinal Permeability and Cytotoxic Activity of Doxorubicin [PDF]

Pharmaceuticals
Background/Objectives: Doxorubicin is an anthracycline chemotherapeutic agent widely used in the treatment of breast cancer. However, its clinical utility is limited by the drug’s resistance development, low oral bioavailability, and dose-dependent side ...
Ghada Saad, Rana M. Alquwayi, Hanin B. Alanazi, Farah B. Aldahmashi, Aryam M. Alahmary, Shouq K. Almutairi, Fatima R. Alshammari, Ghadah T. Alshammari, Afnan J. Alrashidi, Norah K. Aldousari, Haifa F. Alsubiei, Lama H. Alanazi, Meaad H. Aldossary, Amal A. Sultan   +13 more
doaj   +2 more sources

Study of Absorption Characteristics of the Total Saponins From Radix Ilicis Pubescentis in an in Situ Single-Pass Intestinal Perfusion (SPIP) Rat Model by Using Ultra Performance Liquid Chromatography (UPLC)

Molecules, 2017
In contrast to the extensively reported therapeutic activities, far less attention has been paid to the intestinal absorption of the total saponins from Radix Ilicis Pubescentis (in Chinese Mao-Dong-Qing, MDQ).
Zhongxiang Zhao, Lei Zhang, Meng Wang
exaly   +3 more sources

Estimation of Catha edulis (Vahl) Forssk. ex Endl. – antidiabetic drug interactions by using closed-loop Doluisio’s method [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Catha edulis (khat) is a prevalent plant in Yemen and other African regions. In Yemen and other countries, most people chew this plant, which may change the pharmacokinetics of many drugs, such as anti-diabetics (glibenclamide and metformin).
Ahmed M. Al-Ghani, Mohammed A. Al-Khawlani, Anes A.M. Thabet   +2 more
doaj   +1 more source

Effect of Cosolvents on the Absorptive Clearance of Ketotifen Fumarate from Rabbit Intestine, In-situ [PDF]

Journal of Advanced Pharmacy Research, 2018
Objective: Investigate the effect of ethanol, polyethylene glycol 400, propylene glycol, glycerol and sorbitol on the absorptive clearance of ketotifen fumarate   in the rabbit.
Sanaa El-Gizawy, Mohamed Osman, Sammar Ibrahim   +2 more
doaj   +1 more source

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

Pharmaceutics, 2022
The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the pKa and the pH-solubility profile were
Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez   +7 more
doaj   +1 more source

Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat [PDF]

Advanced Pharmaceutical Bulletin, 2023
Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in a self-microemulsifying drug delivery system (SMEDDS) to improve the solubility, release rate, and intestinal permeability of the drug. Methods: The suitable
Shahla Mirzaeei, Negar Tahmasebi, Ziba Islambulchilar   +2 more
doaj   +1 more source

TAURINE AND CAFFEINE-CONTAINING ENERGY DRINKS: LUMINAL PRESENCE OF TAURINE REDUCES BACLOFEN INTESTINAL ABSORPTION IN RATS [PDF]

Kafrelsheikh Veterinary Medical Journal, 2004
The absorption of baclofen (BAC), a centrally acting antispastic agent with γ-amino acid structure as well as the influence of taurine (TAU) and caffeine (CAFF) on baclofen permeability was investigated by in-situ single-pass rat intestinal perfusion ...
H. Spahn-Langguth, A. Hanafy, C. Leisen
doaj   +1 more source

Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies

Pharmaceutics, 2022
The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study.
Marlies Braeckmans, Patrick Augustijns, Raf Mols, Cécile Servais, Joachim Brouwers   +4 more
doaj   +1 more source