Results 1 to 10 of about 128,811 (259)

Associations between food-specific IgG antibodies and intestinal permeability biomarkers

Frontiers in Nutrition, 2022
Increasing translational evidence suggests that intestinal permeability may be a contributing factor to systemic inflammatory events and numerous pathologies.
Alexandra Adorno Vita, Heather Zwickey, Ryan Bradley, Ryan Bradley   +3 more
doaj   +1 more source

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Pharmaceutics, 2020
Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model.
David Dahlgren, Maria-Jose Cano-Cebrián, Tobias Olander, Mikael Hedeland, Markus Sjöblom, Hans Lennernäs   +5 more
doaj   +1 more source

Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury. [PDF]

PLoS ONE, 2015
Beta-adrenergic blockade has been hypothesized to have a protective effect on intestinal dysfunction and increased intestinal permeability associated with the epinephrine surge after traumatic brain injury (TBI).Wister rats were subjected to either a ...
Yuhuang Lang, Fengming Fu, Dalong Sun, Chenhui Xi, Fengyuan Chen   +4 more
doaj   +1 more source

Alterations in intestinal permeability [PDF]

Gut, 2006
The goal of this review is to describe barrier function of the intestine, the structure of the tight junction, methods to evaluate intestinal permeability, and most importantly the relevance of abnormal permeability to disease. In this context, we will also present an emerging paradigm regarding the genesis of autoimmune diseases and describe the data ...
M C, Arrieta, L, Bistritz, J B, Meddings
openaire   +2 more sources

Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal PermeabilitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development.
Jay Luther, John J. Garber, Hamed Khalili, Maneesh Dave, Shyam Sundhar Bale, Rohit Jindal, Daniel L. Motola, Sanjana Luther, Stefan Bohr, Soung Won Jeoung, Vikram Deshpande, Gurminder Singh, Jerrold R. Turner, Martin L. Yarmush, Raymond T. Chung, Suraj J. Patel   +15 more
doaj   +1 more source

Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. [PDF]

PLoS ONE, 2011
BackgroundThe cytokines TNF (TNFSF2) and IFNγ are important mediators of inflammatory bowel diseases and contribute to enhanced intestinal epithelial permeability by stimulating apoptosis and/or disrupting tight junctions.
Kati Juuti-Uusitalo, Leon J Klunder, Klaas A Sjollema, Katarina Mackovicova, Ryuichi Ohgaki, Dick Hoekstra, Jan Dekker, Sven C D van Ijzendoorn   +7 more
doaj   +1 more source

Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats

Nutrition & Metabolism, 2010
Background An increase in the intestinal permeability is considered to be associated with the inflammatory tone and development in the obesity and diabetes, however, the pathogenesis of the increase in the intestinal permeability is poorly understood ...
Suzuki Takuya, Hara Hiroshi
doaj   +1 more source

The role of the intestinal permeability in the progression of nonalcoholic fatty liver disease in obese children

Gastroenterologìa, 2022
Many studies in recent years have revealed increased intestinal permeability in the non-alcoholic fatty liver disease (NAFLD) development and progression to nonalcoholic steatohepatitis (NASH) and liver fibrosis.
Yu.M. Stepanov, N.Yu. Zavhorodnia, N.O. Zhyhyr   +2 more
doaj   +1 more source

Expanding the utility of the dextran sulfate sodium (DSS) mouse model to induce a clinically relevant loss of intestinal barrier function [PDF]

PeerJ, 2020
Background Inflammatory bowel disease (IBD) is a family of debilitating disorders that affects more than 1 million people in the United States. Many animal studies of IBD use a dextran sulfate sodium (DSS) mouse model of colitis that induces rapid and ...
Kyle E. Cochran, Nicholas G. Lamson, Kathryn A. Whitehead   +2 more
doaj   +2 more sources

The phenomenon of intestinal permeability and its association with cardiovascular disease. Current status

Кардиоваскулярная терапия и профилактика, 2020
Changes in the intestinal permeability in various pathologies are widely discussed in the scientific community. There is still no consensus on whether high intestinal permeability can lead to chronic noncommunicable diseases, but there is much evidence ...
D. A. Kashtanova, O. N. Tkacheva
doaj   +1 more source