Results 41 to 50 of about 843,325 (293)

Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation.

PLoS ONE, 2021
BackgroundMatrix Metalloproteinase-9 (MMP-9) has been shown to play a key role in mediating inflammation and tissue damage in inflammatory bowel disease (IBD).
Rana Al-Sadi, Jessica Engers, Mohammad Haque, Steven King, Deemah Al-Omari, Thomas Y Ma   +5 more
doaj   +1 more source

Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury [PDF]

, 2008
Background A partially hydrolysed and dried product of pacific whiting fish is marketed as a health food supplement supporting 'intestinal health'.Aim To examine whether the partially hydrolysed and dried product of pacific whiting fish influenced the ...
Marchbank, T, Mahmood, A, Elia, G, Limdi, JK, Playford, RJ   +4 more
core   +1 more source

TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. [PDF]

PLoS ONE, 2011
Tight junctions between intestinal epithelial cells mediate the permeability of the intestinal barrier, and loss of intestinal barrier function mediated by TNF signaling is associated with the inflammatory pathophysiology observed in Crohn's disease and ...
Lauren E Kolodziej, James P Lodolce, Jonathan E Chang, Jeffrey R Schneider, Wesley A Grimm, Sarah J Bartulis, Xiaorong Zhu, Jeannette S Messer, Stephen F Murphy, Nishith Reddy, Jerrold R Turner, David L Boone   +11 more
doaj   +1 more source

A permeability assay for mouse intestinal organoids [PDF]

, 2022
Here, we describe an assay for intestinal permeability in mouse intestinal organoids, although this may also be adapted for other species. Propidium iodide (PI) does not penetrate intact biological membranes and thus cannot enter the lumen of intact ...
Chokshi, Shilpa, den Daas, Stijn Aaron, Mehta, Gautam, Soffientini, Ugo   +3 more
core   +2 more sources

Intestinal permeability. [PDF]

Gut, 1994
Damage to the mucosal barrier may be assessed, non-invasively by use of sugar probes, which permeate through the transcellular or paracellular (tight junction) routes. A standardised test, with analysis of a five hour urine collection has proved useful in studying the sequelae of non-steroid anti-inflammatory drug (NSAID) administration, untreated ...
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Intestinal Ketogenesis and Permeability

International Journal of Molecular Sciences
Consumption of a high-fat diet (HFD) has been suggested as a contributing factor behind increased intestinal permeability in obesity, leading to increased plasma levels of microbial endotoxins and, thereby, increased systemic inflammation. We and others have shown that HFD can induce jejunal expression of the ketogenic rate-limiting enzyme ...
Anna Casselbrant, Erik Elias, Peter Hallersund, Erik Elebring, Jakob Cervin, Lars Fändriks, Ville Wallenius   +6 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Prebiotic Modulation of Intestinal Permeability [PDF]

, 2022
The maintenance of a functional intestinal barrier is critical to overall health, as a “leaky gut”, often a result of age-associated defects in intestinal barrier integrity, can lead to systemic health problems, including dysregulated inflammation and ...
Zasloff, Rebecca
core   +1 more source