Results 51 to 60 of about 843,325 (293)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Geography of intestinal permeability and absorption [PDF]

Gut, 1999
BACKGROUND Intestinal morphology and function vary geographically. AIMS These functions were assessed in asymptomatic volunteers in European, North American, Middle Eastern, Asian, African, and Caribbean countries.
I S, Menzies, M J, Zuckerman, W S, Nukajam, S G, Somasundaram, B, Murphy, A P, Jenkins, R S, Crane, G G, Gregory   +7 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bacteria Remediate the Effects of Food Additives on Intestinal Function in an in vitro Model of the Gastrointestinal Tract

Frontiers in Nutrition, 2020
As the site of nutrient absorption, the small intestine is continuously exposed to preservatives and additives present in consumed food. While the effects of diet on the lower gastrointestinal tract are widely studied, the effects of food additives on ...
Mridu Malik, Mridu Malik, Sanjeena Subedi, Cláudia N. H. Marques, Cláudia N. H. Marques, Gretchen J. Mahler, Gretchen J. Mahler   +6 more
doaj   +1 more source

Highly Sensitive, Flow Cytometry-Based Measurement of Intestinal Permeability in Models of Experimental ColitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Increased intestinal permeability is seen in a variety of inflammatory conditions such as enteric infections and inflammatory bowel disease.
Kevin Tsai, Caixia Ma, Xiao Han, Joannie Allaire, Genelle R. Healey, Shauna M. Crowley, Hongbing Yu, Kevan Jacobson, Lijun Xia, John J. Priatel, Bruce A. Vallance   +10 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Intestinal permeability to iohexol as an in vivo marker of chemotherapy-induced gastrointestinal toxicity in Sprague-Dawley rats [PDF]

, 2016
Gastrointestinal toxicity is the most common adverse effect of chemotherapy. Chemotherapeutic drugs damage the intestinal mucosa and increase intestinal permeability.
Spillmann, Thomas, Lindén, Jere,, Richard A. Forsgård, Pia Österlund, Holma, Reetta,, Spillmann, Thomas,, Österlund, Pia,, Jere Lindén, Lindén, Jere, Linden, J, Riitta Korpela, Frias, R, Osterlund, P, Frias, Rafael,, Rafael Frias, Thomas Spillmann, Holma, R, Frias, Rafael, Holma, Reetta, Korpela, R, Reetta Holma, Korpela, Riitta, Spillmann, T, Österlund, Pia, Forsgård, Richard A., Forsgard, RA, Forsgård, Richard A.,, Korpela, Riitta,   +27 more
core   +2 more sources

Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis

Molecular Medicine
Background Obesity is a significant risk factor for severe acute pancreatitis (SAP) and is typically associated with increased intestinal permeability. Understanding the role of specific molecules can help reduce the risk of developing SAP.
Lihui Lin, Yansong Lin, Xianwen Guo, Ruoyi Zhang, Xin Ling, Zewen Zhang, Rong Lin, Zhen Ding   +7 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium [PDF]

, 2008
This report is a summary of the symposium on Alcohol, Intestinal Bacterial Growth, Intestinal Permeability to Endotoxin, and Medical Consequences, organized by National Institute on Alcohol Abuse and Alcoholism, Office of Dietary Supplements, and ...
Hamilton, Frank, Sartor, R. Balfour, Bode, Christiane, Kang, Y. James, Turner, Jerrold R., Purohit, Vishnudutt, Brenner, David A., Choudhry, Mashkoor A., Keshavarzian, Ali, Swanson, Christine, Bode, J. Christian, Rao, Radhakrishna   +11 more
core   +1 more source