Results 21 to 30 of about 128,811 (259)

Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation.

PLoS ONE, 2021
BackgroundMatrix Metalloproteinase-9 (MMP-9) has been shown to play a key role in mediating inflammation and tissue damage in inflammatory bowel disease (IBD).
Rana Al-Sadi, Jessica Engers, Mohammad Haque, Steven King, Deemah Al-Omari, Thomas Y Ma   +5 more
doaj   +1 more source

Improvement of gut microbiome and intestinal permeability following splenectomy plus pericardial devascularization in hepatitis B virus-related cirrhotic portal hypertension

Frontiers in Immunology, 2022
The gut microbiome is an essential component of the intestinal mucosal barrier, critical in regulating intestinal permeability. Microbiome dysbiosis and intestinal permeability changes are commonly encountered conditions in patients with cirrhosis and ...
Yang Zhao, Yang Zhao, Rui Zhou, Rui Zhou, Ying Guo, Ying Guo, Xi Chen, Xi Chen, Aiyu Zhang, Aiyu Zhang, Jiayin Wang, Fanpu Ji, Fanpu Ji, Fanpu Ji, Bowen Qin, Bowen Qin, Jing Geng, Jing Geng, Guangyao Kong, Guangyao Kong, Zongfang Li, Zongfang Li, Zongfang Li   +22 more
doaj   +1 more source

TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. [PDF]

PLoS ONE, 2011
Tight junctions between intestinal epithelial cells mediate the permeability of the intestinal barrier, and loss of intestinal barrier function mediated by TNF signaling is associated with the inflammatory pathophysiology observed in Crohn's disease and ...
Lauren E Kolodziej, James P Lodolce, Jonathan E Chang, Jeffrey R Schneider, Wesley A Grimm, Sarah J Bartulis, Xiaorong Zhu, Jeannette S Messer, Stephen F Murphy, Nishith Reddy, Jerrold R Turner, David L Boone   +11 more
doaj   +1 more source

Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion

Frontiers in Immunology, 2023
IntroductionThe intestinal barrier plays a crucial role in distinguishing foods from toxins. Prostaglandin D2 (PGD2) is one of the lipid-derived autacoids synthesized from cell membrane-derived arachidonic acid.
Akane Hayashi, Naoaki Sakamoto, Koji Kobayashi, Takahisa Murata, Takahisa Murata, Takahisa Murata   +5 more
doaj   +1 more source

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. [PDF]

PLoS ONE, 2015
The development of intestinal permeability and the penetration of microbial products are key factors associated with the onset of metabolic disease. However, the mechanisms underlying this remain unclear. Here we show that, unlike liver or adipose tissue,
Andrew M F Johnson, Anne Costanzo, Melanie G Gareau, Aaron M Armando, Oswald Quehenberger, Julie M Jameson, Jerrold M Olefsky   +6 more
doaj   +1 more source

Increased intestinal permeability in primary Sjögren’s syndrome and multiple sclerosis

Journal of Translational Autoimmunity, 2021
There is increasing evidence suggesting a role of intestinal dysfunction in a number of autoimmune diseases. Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease with a documented increased level of intestinal inflammation, whereas multiple ...
Bitte Sjöström, Anders Bredberg, Thomas Mandl, Lucía Alonso-Magdalena, Bodil Ohlsson, Shahram Lavasani, Mehrnaz Nouri, Gunnel Henriksson   +7 more
doaj   +1 more source

Sauna dehydration as a new physiological challenge model for intestinal barrier function

Scientific Reports, 2021
The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier
Maria Fernanda Roca Rubio, Ulrika Eriksson, Robert J. Brummer, Julia König   +3 more
doaj   +1 more source

Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability

Diagnostics, 2023
The study of intestinal permeability is gaining growing interest due to its relevance in the onset and progression of several gastrointestinal and non-gastrointestinal diseases.
Nuria Perez-Diaz-del-Campo, Gabriele Castelnuovo, Davide Giuseppe Ribaldone, Gian Paolo Caviglia   +3 more
doaj   +1 more source

Intestinal permeability. [PDF]

Gut, 1994
Damage to the mucosal barrier may be assessed, non-invasively by use of sugar probes, which permeate through the transcellular or paracellular (tight junction) routes. A standardised test, with analysis of a five hour urine collection has proved useful in studying the sequelae of non-steroid anti-inflammatory drug (NSAID) administration, untreated ...
openaire   +2 more sources

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source