Results 1 to 10 of about 118,468,089 (143)
Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique [PDF]
Pharmaceutics, 2021 Oleacein (OLEA) is one of the most important phenolic compounds in extra virgin olive oil in terms of concentration and health-promoting properties, yet there are insufficient data on its absorption and metabolism.
Anallely López-Yerena +5 more
doaj +2 more sources
Molecules, 2017 In contrast to the extensively reported therapeutic activities, far less attention has been paid to the intestinal absorption of the total saponins from Radix Ilicis Pubescentis (in Chinese Mao-Dong-Qing, MDQ).
Guojun Kuang +9 more
doaj +3 more sources
The Effects of Cetirizine on P-glycoprotein Expression and Function In vitro and In situ [PDF]
Advanced Pharmaceutical Bulletin, 2016 Purpose: P-glycoprotein (P-gp) plays a major role in oral absorption of drugs. Induction or inhibition of P-gp by drugs contributes to variability of its transport activity and often results in clinically relevant drug-drug interactions.
Mehran Mesgari Abbasi +4 more
doaj +3 more sources
Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in a self-microemulsifying drug delivery system (SMEDDS) to improve the solubility, release rate, and intestinal permeability of the drug. Methods: The suitable
Shahla Mirzaeei +2 more
doaj +1 more source
Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption
Frontiers in Pharmacology, 2021 Background: Sorafenib (SOR) is an oral, potent, selective, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as the first-line therapy for advanced hepatocellular carcinoma (HCC).
Jingyao Wei +13 more
doaj +1 more source
TAURINE AND CAFFEINE-CONTAINING ENERGY DRINKS: LUMINAL PRESENCE OF TAURINE REDUCES BACLOFEN INTESTINAL ABSORPTION IN RATS [PDF]
Kafrelsheikh Veterinary Medical Journal, 2004 The absorption of baclofen (BAC), a centrally acting antispastic agent with γ-amino acid structure as well as the influence of taurine (TAU) and caffeine (CAFF) on baclofen permeability was investigated by in-situ single-pass rat intestinal perfusion ...
H. Spahn-Langguth, A. Hanafy, C. Leisen
doaj +1 more source
Pharmaceutics, 2020 In this paper, as an active ingredient, puerarin chitosan nanoparticles (Pur-CS/TPP-NPs) are prepared by an ionic gelation method. The chitosan (CS) concentration, pH of the CS solution, sodium tripolyphosphate (TPP) concentration, stirring speed ...
Jie Yan +8 more
doaj +1 more source
Molecules, 2021 Opuntia dillenii Ker Gawl. is one of the medicinal plants used for the prevention and treatment of diabetes mellitus (DM) in Morocco. This study aims to investigate the antihyperglycemic effect of Opuntia dillenii seed oil (ODSO), its mechanism of action,
Mohamed Bouhrim +14 more
doaj +1 more source
Pharmaceutics, 2018 The aim of the present study was to assess the regional absorption of fimasartan by an improved in situ absorption method in comparison with the conventional in situ single-pass perfusion method in rats.
Tae Hwan Kim +10 more
doaj +1 more source
Frontiers in Pharmacology, 2020 BackgroundAmomi fructus is a famous traditional Chinese medicine (TCM) that can exert beneficial effects during the treatment of gastrointestinal diseases and is used widely in China and other countries in Southeast Asia.
Yuebao Yao +7 more
doaj +1 more source