Results 21 to 30 of about 118,468,089 (143)

Evaluation of Intestinal Drug Absorption and Interaction Using Quadruple Single-Pass Intestinal Perfusion Coupled with Mass Spectrometry Imaging

, 2023
Visualization and characterization of the intestinal membrane transporter-mediated drug absorption and interaction are challenging due to the complex physical and chemical environment.
Yuejie Zhang, Bin Li (39349), Ping Li, Yuejie Zhang (13310049), Weiwei Tang (1777777), Weiwei Tang, Ping Li (31981), Bin Li   +7 more
core   +1 more source

The Effect of Particle Size on the Absorption of Cyclosporin A Nanosuspensions

International Journal of Nanomedicine, 2022
Wenjun Sun,1 Jing Gao,1 Ranran Fan,2 Ting Zhang,3 Yang Tian,1 Zengming Wang,1 Hui Zhang,1 Aiping Zheng1 1Department of Pharmaceutics, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, People’s Republic of China ...
Sun W, Gao J, Fan R, Zhang T, Tian Y, Wang Z, Zhang H, Zheng A   +7 more
doaj  

Optical Coherence Tomography Imaging of Tissue Engineered Skin Cultured Under Perfusion Conditions [PDF]

, 2013
Tissue engineered (TE) human skin constructs are useful for the investigation of disease pathologies and for exploring the potencies and side effects of medicines and cosmetics.
Robertson, Caroline
core   +4 more sources

The absorption of oral morroniside in rats: In vivo, in situ and in vitro studies

Acta Pharmaceutica, 2019
Morroniside is one of the most important iridoid glycosides from Cornus officinalis Sieb. et Zucc. In the present study, the pharmacokinetics and bioavailability studies of morroniside were conducted on Sprague-Dawley (SD) rats.
Xiong Shan, Li Jinglai, Mu Yanling, Zhang Zhenqing   +3 more
doaj   +1 more source

A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability

Journal of Pharmacy & Pharmaceutical Sciences, 2008
Purpose.To determine the possible mechanism of poor bioavailability of bicyclol, and clarify the respective contribution of P- glycoprotein (P-gp) and Cytochrome 3A (CYP3A). Methods. Rat in situ single-pass intestinal perfusion and Caco-2 cell monolayer
Wei Tan, Hui Chen, Jinping Hu, Yan Li
doaj   +1 more source

PACLITAXEL DISPOSITION STUDIES USING P-GP INHIBTOR & INDUCER BY SINGLE PASS INTESTINAL PERFUSION IN RATS [PDF]

, 2014
Objective: The present research work aims to study the intestinal transport of Paclitaxel and to predict its human intestinal permeability and fraction absorbed using SPIP Permeability Coefficient and the effect of P-gp modulators on Paclitaxel were ...
Raviteja Sagi, S M, P.Shashikanth, Chandra Mohan, P., Karunakar, K   +3 more
core   +1 more source

Engineered small intestinal system as an alternative to in-situ intestinal permeability model

, 2018
Intestinal permeability is the most important factor that determines the bioavailability. In-vitro techniques like Caco-2 model and Ussing chamber are used for evaluating the intestinal permeability of the bioactive compound.
S. Parthasarathi, C. Anandharamakrishnan, Anu Bhushani, J., J. Anu Bhushani, Parthasarathi, S., Anandharamakrishnan, C.   +5 more
core   +1 more source

Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid

Asian Journal of Pharmaceutical Sciences, 2017
Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis.
Wenjuan Zhang, Chufan Liang, Hao Liu, Zhenbao Li, Rui Chen, Mei Zhou, Dan Li, Qing Ye, Cong Luo, Jin Sun   +9 more
doaj   +1 more source

Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat

, 2017
The flower bud of Daphne genkwa (Genkwa Flos) is a commonly used herbal medicine in Asian countries. Luteolin and apigenin are two recognized active flavonoids in Genkwa Flos. The aim of this study was to investigate the intestinal absorption mechanisms
Xin He, Cui-Ping Jiang, Zi-Jing Song, Chun-Feng Zhang   +3 more
core   +1 more source

Stereoselective property of 20(S)-protopanaxadiol ocotillol type epimers affects its absorption and also the inhibition of P-glycoprotein. [PDF]

PLoS ONE, 2014
Stereoselectivity has been proved to be tightly related to drug action including pharmacodynamics and pharmacokinetics. (20S,24R)-epoxy-dammarane-3,12,25-triol (24R-epimer) and (20S,24S)-epoxy-dammarane-3,12,25-triol (24S-epimer), a pair of 20(S ...
Wenyan Wang, Xiangmeng Wu, Li Wang, Qingguo Meng, Wanhui Liu   +4 more
doaj   +1 more source