Results 11 to 20 of about 118,468,089 (143)
Journal of the Formosan Medical Association, 2008 First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was developed for measuring different concentrations of pharmaceuticals in the portal vein and hepatic vein (via the inferior vena cava) for delineating ...
Yunn-Fang Ho +6 more
doaj +2 more sources
FROG INTESTINAL PERFUSION TO EVALUATE DRUG PERMEABILITY: APPLICATION TO P-gp AND CYP3A4 SUBSTRATES [PDF]
Frontiers in Pharmacology, 2015 To evaluate the reliability of using in situ frog intestinal perfusion technique for permeability assessment of carrier transported drugs which are also substrates for CYP enzymes.
Neelima eYerasi +2 more
doaj +2 more sources
In Situ Intestinal Perfusion of Irinotecan: Application to P-gp Mediated Drug Interaction and Introduction of an Improved HPLC Assay [PDF]
Journal of Pharmacy & Pharmaceutical Sciences, 2011 PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotecan, and to quantify the amount of its cytotoxic metabolite SN-38 that is intestinally excreted (exsorped) as a predictor of intestinal toxicity, and to ...
Abdullah Khalil Rabba +4 more
doaj +2 more sources
Acta Pharmaceutica Sinica B, 2014 The aim of this study was to develop a formulation to improve the oral absorption of baicalin (BA) by combining a phospholipid complex (PC) and self-emulsifying microemulsion drug delivery system (SMEDDS), termed BA–PC–SMEDDS.
Huiyi Wu +7 more
doaj +2 more sources
Effects of Piperine on the Intestinal Permeability and Pharmacokinetics of Linarin in Rats
Molecules, 2014 Although linarin possesses diverse pharmacological activities, its poor oral bioavailability has been a concern for further development. The present study aimed to demonstrate the feasibility of improving the oral absorption of linarin in rats with a ...
Xinchi Feng +3 more
doaj +2 more sources
Drug Delivery, 2020 Repaglinide-loaded nanostructured lipid carriers (REP-NLCs) with different particle sizes were successfully designed and prepared to investigate the permeation and absorption ability by in situ single-pass intestinal perfusion (SPIP) study and ...
Lei Wu +4 more
doaj +2 more sources
Effect of berbamine hydrochloride on the absorption of berberine hydrochloride in an in situ single-pass intestinal perfusion system in rats [PDF]
, 2022 Purpose: To investigate the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats.Methods: Based on the in situ single-pass intestinal perfusion model of rats, HPLC was used to determine the ...
Bi, Ruohong +15 more
core +1 more source
Research in Pharmaceutical Sciences, 2016 P-glycoprotein (P-gp) is a trans-membrane drug efflux pump. Several drugs are P-gp substrates. Some drugs may affect the activity of P-gp by inhibiting its function, resulting in significant drug-drug interactions (DDIs).
Mehran Mesgari Abbasi +3 more
doaj +1 more source
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Dufès, Christine +5 more
core +3 more sources
Assessment of absorption of four lignan constituents of JingNing particles in rat gut using <i>in situ</i> single-pass intestinal perfusion [PDF]
, 2017 Purpose: To study small intestinal absorption of schisadrol A, schisandrol B, schizandrin A and schisandrin B in JingNing particles using in situ single-pass intestinal perfusion (SPIP).Methods: Absorption rate constant (Ka) and apparent permeability ...
Jing Fu +21 more
core +1 more source