Results 31 to 40 of about 118,468,089 (143)

Computer-assisted ex vivo, normothermic small bowel perfusion [PDF]

, 2000
Background: In the present study, a technique for computer-assisted, normothermic, oxygenated, ex vivo, recirculating small bowel perfusion was established as a tool to investigate organ pretreatment protocols and ischemia/reperfusion phenomena.
Theodorou, D., Hammer, C., Schildberg, Friedrich Wilhelm, Eder, M., Land, W., Stangl, M. J., Krapp, J.   +6 more
core   +1 more source

Raloxifene/SBE-β-CD Inclusion Complexes Formulated into Nanoparticles with Chitosan to Overcome the Absorption Barrier for Bioavailability Enhancement

Pharmaceutics, 2018
Raloxifene (RXF) is a hormone-like medication used for treating postmenopausal osteoporosis and estrogen-dependent breast cancer, yet associated with bad low bioavailability due to poor solubility. This study was intended to develop cyclodextrin/chitosan
Zaihua Wang, Yan Li
doaj   +1 more source

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source

Intestinal permeability and role of P-glycoprotein in intestinal absorption of novel triethylamine containing thiophene S006–830 using single-pass intestinal perfusion in rats

, 2017
Aim: Study was designed to develop ultra-fast liquid chromatography method of antitubercular compound S006–830 in rat intestinal perfusate and apply method for determination of effective permeability coefficient (Peff), absorption rate (Ka) and role of ...
Mahendra Kumar Hidau, Yeshwant Singh, Shio Kumar Singh   +2 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Enhanced Oral Bioavailability of Domperidone with Piperine in Male Wistar Rats: Involvement of CYP3A1 and P-gp Inhibition

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Purpose: Domperidone is a commonly used antiemetic drug. The oral bioavailability of domperidone is very low due to its rapid first pass metabolism in the intestine and liver.
Bhargavi Latha Athukuri, Prasad Neerati
doaj   +1 more source

In vitro and in situ study on characterization and mechanism of the intestinal absorption of 2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside

BMC Pharmacology and Toxicology, 2020
Background 2,3,5,4′-tetrahydroxystilbence-2-O-β-D-glucoside (TSG) is a polyhydroxyphenolic compound, which exhibited a broad spectrum of pharmacological activities, such as anti-inflammatory, anti-depression, anti-oxidation and anti-atherosclerosis ...
Cheng Wang, Yimeng Zhou, Xiaohong Gong, Li Zheng, Yunxia Li   +4 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Changes in the pharmacokinetics of glibenclamide in rats with streptozotocin-induced diabetes mellitus

Acta Pharmaceutica Sinica B, 2012
The aim of this study was to investigate the pharmacokinetics of glibenclamide (Gli) administrated orally and intravenously to normal and diabetic rats.
Yuqing Li, Yuhui Wei, Fan Zhang, Dan Wang, Xinan Wu   +4 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source