Results 1 to 10 of about 53,962 (242)
Caco-2 Cell Line Standardization with Pharmaceutical Requirements and In Vitro Model Suitability for Permeability Assays [PDF]
Pharmaceutics, 2023 The Caco-2 cell line derived from human colon carcinoma is commonly used to assess the permeability of compounds in in vitro conditions. Due to the significant increase in permeability studies using the Caco-2 cell line in recent years, the need to ...
Marta Kus +2 more
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Tranexamic acid inhibits mitochondrial DNA release and reduces inflammatory response in an in vitro model of OGD/R-induced Caco-2 cell injury [PDF]
BMC Pharmacology and ToxicologyBackground Ischemia-reperfusion (I/R) injury of the intestine remains a challenging clinical issue, and there is currently no definitive treatment protocol.
Ziyue Wang +4 more
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Application of ECIS to Evaluate the Effects of Porcine Urinary Bladder Matrix Hydrogels on Caco-2 Cell Attachment, Migration, and Barrier Formation [PDF]
GelsRecent studies have highlighted the potential of urinary bladder matrix (UBM) derived from decellularized porcine urinary bladder as a bioactive hydrogel. Despite its complex composition of over 100 proteins, Type I collagen is the primary constituent of
Wei-Ling Chen +5 more
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Caco-2 models for xenobiotic metabolism and transportation [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 The intestine plays an important role in the absorption, metabolism, and transportation of xenobiotics including drugs and foods. Therefore, an in vitro intestinal model for predicting bioavailability of xenobiotics is important for the drug and food ...
Nathaphon Kuncharoenwirat +2 more
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Scientific Reports, 2021 Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme.
Moe Ichikawa +5 more
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Di-san junyi daxue xuebao, 2020 Objective To compare the potentiality and characteristics of different intestinal epithelial cell (IEC) lines to grow into enteroids when cultured in 3D system in order to provide experimental basis for the cultivation of enteroids by IECs. Methods Three
OU Jing, XU Zhenni, LIU Dengqun
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Chemosensors, 2022 Bitter taste receptors (T2Rs) are involved in bitter taste perception, which is one of the five basic taste modalities in mammals. In this study, a cell co-culture taste sensor using different proportions of Caco-2 cells and SH-SY5Y cells was proposed ...
Chunlian Qin +7 more
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口腔疾病防治, 2023 Objective To investigate the effect of pathogenic bacterium-Porphyromonas gingivalis (P.g) on the proliferation and inflammatory factor expression of human colorectal cancer Caco-2 cells, to determine whether the Janus kinase 2-signal transducers and ...
ZHANG Ruotong , LIU Xiaochen, YE Wei
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PLoS ONE, 2022 We report herein, the design and synthesis of thiazolidine-2,4-diones derivatives as new inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer activity against four cancer cell lines; A549, Caco-2, HepG-2 and MDA-MB-231.
Mohammed S Taghour +10 more
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The transition from proliferation to differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1. [PDF]
PLoS ONE, 2013 Breaking the balance between proliferation and differentiation in animal cells can lead to cancer, but the mechanisms maintaining this balance remain largely undefined.
Bo Yang +4 more
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