Results 1 to 10 of about 54,220 (246)
Scientific Reports, 2021 Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme.
Moe Ichikawa +5 more
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Frontiers in Pharmacology, 2022 It is essential to explore the relationship between drugs and transporters in the process of drug development. Strong background signals in nonhuman MDCK or LLC-PK1 cells and overlapping interference of inhibitors or RNAi in human Caco-2 cells mean that ...
Dongyan Feng +9 more
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Chemosensors, 2022 Bitter taste receptors (T2Rs) are involved in bitter taste perception, which is one of the five basic taste modalities in mammals. In this study, a cell co-culture taste sensor using different proportions of Caco-2 cells and SH-SY5Y cells was proposed ...
Chunlian Qin +7 more
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口腔疾病防治, 2023 Objective To investigate the effect of pathogenic bacterium-Porphyromonas gingivalis (P.g) on the proliferation and inflammatory factor expression of human colorectal cancer Caco-2 cells, to determine whether the Janus kinase 2-signal transducers and ...
ZHANG Ruotong , LIU Xiaochen, YE Wei
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Di-san junyi daxue xuebao, 2020 Objective To compare the potentiality and characteristics of different intestinal epithelial cell (IEC) lines to grow into enteroids when cultured in 3D system in order to provide experimental basis for the cultivation of enteroids by IECs. Methods Three
OU Jing, XU Zhenni, LIU Dengqun
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Frontiers in Cell and Developmental Biology, 2022 Pin1, a cis/trans isomerase of peptidyl-prolyl peptide bonds, plays a crucial role in the pathogenesis of many human cancers. Although chemical inhibitors of Pin1 show potent antitumor therapeutic properties against various cancers, their effect on ...
Junghoon Kim +3 more
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Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression. [PDF]
PLoS ONE, 2014 Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer.
Zhen Liu +8 more
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The effect of Cetuximab and Egg Serum Albumin on Caco-2 cells after 48h incubation with Caco-2 cells [PDF]
Delta Journal of Science, 2023 Cetuximab, an anti-epidermal growth factor receptor monoclonal antibody, has been shown to increase the median survival of colon cancer patients. To establish if egg serum albumin nanoparticles (ESA-NPs), a drug carrier, could be a factor that renders ...
Yasser Abdou +4 more
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World Journal of Surgical Oncology, 2023 Background Inflammatory bowel disease (IBS) is a chronic disorder of the gastrointestinal tract. Exosomes have been involved in various pathological processes including IBS. Apigenin has been reported to suppress inflammatory bowel disease (IBS). However,
Rui Fu +4 more
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Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability
British Journal of Pharmacy, 2023 The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell +5 more
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