Results 1 to 10 of about 52,019 (169)
Scientific Reports, 2021 Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme.
Moe Ichikawa +5 more
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Frontiers in Pharmacology, 2022 It is essential to explore the relationship between drugs and transporters in the process of drug development. Strong background signals in nonhuman MDCK or LLC-PK1 cells and overlapping interference of inhibitors or RNAi in human Caco-2 cells mean that ...
Dongyan Feng +9 more
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Chemosensors, 2022 Bitter taste receptors (T2Rs) are involved in bitter taste perception, which is one of the five basic taste modalities in mammals. In this study, a cell co-culture taste sensor using different proportions of Caco-2 cells and SH-SY5Y cells was proposed ...
Chunlian Qin +7 more
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Metabolism of haem in Caco‐2 cells [PDF]
Experimental Physiology, 2010 The haem oxygenase‐1–biliverdin reductase system degrades haem and generates biliverdin and bilirubin, both of which possess antioxidant and anti‐inflammatory properties. Biliverdin and bilirubin are protective in intestinal injury models, but little is known about their generation and fate in the intestine.
Aliye, Uc +2 more
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口腔疾病防治, 2023 Objective To investigate the effect of pathogenic bacterium-Porphyromonas gingivalis (P.g) on the proliferation and inflammatory factor expression of human colorectal cancer Caco-2 cells, to determine whether the Janus kinase 2-signal transducers and ...
ZHANG Ruotong , LIU Xiaochen, YE Wei
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Frontiers in Cell and Developmental Biology, 2022 Pin1, a cis/trans isomerase of peptidyl-prolyl peptide bonds, plays a crucial role in the pathogenesis of many human cancers. Although chemical inhibitors of Pin1 show potent antitumor therapeutic properties against various cancers, their effect on ...
Junghoon Kim +3 more
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Di-san junyi daxue xuebao, 2020 Objective To compare the potentiality and characteristics of different intestinal epithelial cell (IEC) lines to grow into enteroids when cultured in 3D system in order to provide experimental basis for the cultivation of enteroids by IECs. Methods Three
OU Jing, XU Zhenni, LIU Dengqun
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Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression. [PDF]
PLoS ONE, 2014 Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer.
Zhen Liu +8 more
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The effect of Cetuximab and Egg Serum Albumin on Caco-2 cells after 48h incubation with Caco-2 cells [PDF]
Delta Journal of Science, 2023 Cetuximab, an anti-epidermal growth factor receptor monoclonal antibody, has been shown to increase the median survival of colon cancer patients. To establish if egg serum albumin nanoparticles (ESA-NPs), a drug carrier, could be a factor that renders ...
Yasser Abdou +4 more
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Characterization of Acetylcholinesterase in Caco-2 Cells
Experimental Biology and Medicine, 2002 Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) was solubilized from cultured Caco-2 cells. It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-β-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51 ...
Lauren R, Plageman +2 more
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