Results 1 to 10 of about 97,542,255 (296)

Interface-engineered Caco-2 cell culture on a collagen-coated liquid–liquid interface in a microfluidic device [PDF]

Beilstein Journal of Nanotechnology
Epithelial tissues form selective barriers essential for physiological homeostasis. Conventional in vitro models rely on solid substrates, which limit the physicochemical flexibility of the cellular microenvironment.
Satoru Kuriu, Soo Hyeon Kim
doaj   +2 more sources

Caco-2 models for xenobiotic metabolism and transportation [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2022
The intestine plays an important role in the absorption, metabolism, and transportation of xenobiotics including drugs and foods. Therefore, an in vitro intestinal model for predicting bioavailability of xenobiotics is important for the drug and food ...
Nathaphon Kuncharoenwirat, Waranya Chatuphonprasert, Kanokwan Jarukamjorn   +2 more
doaj   +1 more source

Factors influencing cell differentiation and expressions of cytochrome P450s and transporters in Caco-2 cells [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2021
Absorption, transportation, and first-pass metabolism of xenobiotics, drugs and nutrients taken orally occurs in the intestine, which is a major organ expressing cytochrome P450 enzymes (CYP) and transporters.
Nathaphon Kuncharoenwirat, Waranya Chatuphonprasert, Kanokwan Jarukamjorn   +2 more
doaj   +1 more source

Investigating the Role of the NLRP3 Inflammasome Pathway in Acute Intestinal Inflammation: Use of THP-1 Knockout Cell Lines in an Advanced Triple Culture Model

Frontiers in Immunology, 2022
The NLRP3 inflammasome plays an important role in intestinal homeostasis as well as inflammation. However, in vivo studies investigating the role of the NLRP3 inflammasome in inflammatory bowel disease (IBD) report contrasting results, leaving it unclear
Mathias Busch, Haribaskar Ramachandran, Tina Wahle, Andrea Rossi, Roel P. F. Schins   +4 more
doaj   +1 more source

A Novel Eye Drop Candidate for Age-Related Macular Degeneration Treatment: Studies on its Pharmacokinetics and Distribution in Rats and Rabbits

Molecules, 2020
Age-related macular degeneration (AMD) is wearing down of macula of retina, causing a blur or loss of vision in the center of the visual field. It can be categorized into dry or wet AMD.
Eun-Jeong Choi, Go-Wun Choi, Ju Hee Kim, Hee-Woon Jang, Ju-Hee Lee, Hyun Ju Bae, Young Gwan Kim, Yong-Bok Lee, Hea-Young Cho   +8 more
doaj   +1 more source

Biological Redox Impact of Tocopherol Isomers Is Mediated by Fast Cytosolic Calcium Increases in Living Caco-2 Cells

Antioxidants, 2020
Most of the biological impacts of Vitamin E, including the redox effects, have been raised from studies with α-tocopherol only, despite the fact that tocopherol-containing foods carry mixed tocopherol isomers.
Miltha Hidalgo, Vania Rodríguez, Christine Kreindl, Omar Porras   +3 more
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The autoimmune susceptibility gene, PTPN2, restricts expansion of a novel mouse adherent-invasive E. coli

Gut Microbes, 2020
Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene increase
Ali Shawki, Rocio Ramirez, Marianne R. Spalinger, Paul M. Ruegger, Anica Sayoc-Becerra, Alina N. Santos, Pritha Chatterjee, Vinicius Canale, Jonathan D. Mitchell, John C. Macbeth, Casey M. Gries, Michel L. Tremblay, Ansel Hsiao, James Borneman, Declan F. McCole   +14 more
doaj   +1 more source

Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system

Scientific Reports, 2021
Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme.
Moe Ichikawa, Hiroki Akamine, Michika Murata, Sumito Ito, Kazuo Takayama, Hiroyuki Mizuguchi   +5 more
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Formulation of a Phenol-Rich Extract from Unripe Olives (Olea europaea L.) in Microemulsion to Improve Its Solubility and Intestinal Permeability

Molecules, 2020
The beneficial properties of phenolic compounds from Olea europaea L. are well-known. An olive extract (OE) was prepared from unripe olives (Moraiolo cultivar). The study aimed to formulate OE into a microemulsion (ME) in oral dosage form.
Lorenzo Cecchi, Vieri Piazzini, Mario D’Ambrosio, Cristina Luceri, Federica Rocco, Marzia Innocenti, Giulia Vanti, Nadia Mulinacci, Maria Camilla Bergonzi   +8 more
doaj   +1 more source

Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability

British Journal of Pharmacy, 2023
The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell, Hannah Batchelor, James Matthew Butler, Ibrahim Khadra, Nena Minstry, Konstantinos Stamatopoulos   +5 more
doaj   +1 more source