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Interface-engineered Caco-2 cell culture on a collagen-coated liquid–liquid interface in a microfluidic device [PDF]
Beilstein Journal of NanotechnologyEpithelial tissues form selective barriers essential for physiological homeostasis. Conventional in vitro models rely on solid substrates, which limit the physicochemical flexibility of the cellular microenvironment.
Satoru Kuriu, Soo Hyeon Kim
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Caco-2 models for xenobiotic metabolism and transportation [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 The intestine plays an important role in the absorption, metabolism, and transportation of xenobiotics including drugs and foods. Therefore, an in vitro intestinal model for predicting bioavailability of xenobiotics is important for the drug and food ...
Nathaphon Kuncharoenwirat +2 more
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Factors influencing cell differentiation and expressions of cytochrome P450s and transporters in Caco-2 cells [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2021 Absorption, transportation, and first-pass metabolism of xenobiotics, drugs and nutrients taken orally occurs in the intestine, which is a major organ expressing cytochrome P450 enzymes (CYP) and transporters.
Nathaphon Kuncharoenwirat +2 more
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Metabolism of haem in Caco‐2 cells [PDF]
Experimental Physiology, 2010 The haem oxygenase‐1–biliverdin reductase system degrades haem and generates biliverdin and bilirubin, both of which possess antioxidant and anti‐inflammatory properties. Biliverdin and bilirubin are protective in intestinal injury models, but little is known about their generation and fate in the intestine.
Aliye, Uc +2 more
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Frontiers in Immunology, 2022 The NLRP3 inflammasome plays an important role in intestinal homeostasis as well as inflammation. However, in vivo studies investigating the role of the NLRP3 inflammasome in inflammatory bowel disease (IBD) report contrasting results, leaving it unclear
Mathias Busch +4 more
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Molecules, 2020 Age-related macular degeneration (AMD) is wearing down of macula of retina, causing a blur or loss of vision in the center of the visual field. It can be categorized into dry or wet AMD.
Eun-Jeong Choi +8 more
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Antioxidants, 2020 Most of the biological impacts of Vitamin E, including the redox effects, have been raised from studies with α-tocopherol only, despite the fact that tocopherol-containing foods carry mixed tocopherol isomers.
Miltha Hidalgo +3 more
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Application of Fucoidan in Caco-2 Model Establishment
Pharmaceuticals, 2022 The Caco-2 model is a common cell model for material intestinal absorption in vitro, which usually takes 21 days to establish. Although some studies have shown that adding puromycin (PM) can shorten the model establishment period to 7 days, this still requires a long modeling time.
Qiong Yang +7 more
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Gut Microbes, 2020 Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene increase
Ali Shawki +14 more
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Scientific Reports, 2021 Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme.
Moe Ichikawa +5 more
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