Results 41 to 50 of about 56,978 (263)

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

Advanced Materials Technologies, EarlyView.
A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García, Jacques Leng, Hugo de Oliveira, Pierre Nassoy, Karine Dementhon   +4 more
wiley   +1 more source

Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE

Разработка и регистрация лекарственных средств, 2019
In this work the intestinal permeability of phospazide in vitro was investigated using Caco-2 cell model in apical-basolateral (A-B) and basolateral-apical (B-A) directions as well as with the option of adding of P-glycoprotein (Pgp) inhibitor ...
D. Yu. Grebenkin, Ya. M. Stanishevskiy, I. E. Shohin, A. M. Stoinova, M. A. Karpova, A. G. Koryakova, A. V. Ryabova, B. V. Brovchenko, A. A. Smirnov   +8 more
doaj  

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Automating Chemical Reasoning in High‐Throughput Phase Identification With a Probabilistic, LLM‐Guided Framework

Advanced Science, EarlyView.
Autonomous laboratories can now synthesize materials faster than experts can interpret the resulting diffraction data. A probabilistic framework combines refinement‐fit metrics with large language model‐derived chemical reasoning to rank competing phase interpretations and flag those unsuitable for autonomous use.
Olympia Dartsi, Lauren N. Walters, Amalie E. Trewartha, Steven B. Torrisi, Amanda Volk, Liam Joyce, Gerbrand Ceder, Anubhav Jain   +7 more
wiley   +1 more source

Development of New Red-Fleshed Seedless Table Grapes: In Vitro Insights on Glucose Absorption and Insulin Resistance Biomarkers

Foods
There is increasing interest in foods that support both physical and psychological health. Red and black fruits are notable for their high phenolic content and associated biological activities.
Ana Belén Bautista-Ortín, Alejandro Martínez-Moreno, Ana Leticia Pérez-Mendoza, María José Carrasco-Palazón, Lucía Osete-Alcaraz, Laura Soriano-Romaní, Elena Díez-Sánchez, Juan Antonio Nieto, Sonia Soto-Jover, Encarna Gómez-Plaza   +9 more
doaj   +1 more source

Measuring oxygen levels in Caco-2 cultures

Hypoxia, 2015
Measuring oxygen levels in three different systems of Caco-2 cell culture.Caco-2 cells were cultured in three different systems, using conventional polystyrene 24-well plates, special 24-well gas permeable plates, or on membrane inserts in conventional plates.
Zeitouni, Nathalie E., Fandrey, Joachim, Naim, Hassan Y., von Köckritz-Blickwede, Maren   +3 more
openaire   +4 more sources

From Flow to Function: Using Different Static Mixers to Fabricate Microarchitected Materials Via Chaotic Printing

Advanced Science, EarlyView.
Complex microarchitectures emerge from simple flow‐driven transformations as static mixers iteratively reorient and split material domains. Coupled with diverse deposition strategies, chaotic printing provides an accessible platform for fabricating architected materials that support biologically and chemically relevant processes. ABSTRACT Nature builds
Edna Johana Bolívar‐Monsalve, Carlos Fernando Ceballos‐González, Diego Alonso Quevedo‐Moreno, Irving Isaí Rendón‐Moreno, Ariel Cantoral‐Sánchez, Héctor Ambriz‐González, Mario Moisés Alvarez, Grissel Trujillo‐de Santiago   +7 more
wiley   +1 more source

Evaluation of the effect of ethylmethylhydroxypyridine succinate on the activity of the BCRP transporter protein in vitro

Фармакокинетика и Фармакодинамика
Relevance. Breast cancer resistance protein (BCRP) is one of the main clinically significant transporter proteins that play an important role in the pharmacokinetics of drugs.
M. I. Povetko, P. Yu. Mylnikov, A. V. Shchulkin, E. N. Yakusheva   +3 more
doaj   +1 more source

Sesquiterpenes α-humulene and β-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells

Acta Pharmaceutica, 2019
The present study is designed to find out if sesquiterpenes, α-humulene (HUM), valencene (VAL), β-caryphyllene-oxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and ...
Ambrož Martin, Šmatová Markéta, Šadibolová Michaela, Pospíšilová Eva, Hadravská Pavlína, Kašparová Michaela, Skarková Veronika Hanušová, Králová Věra, Skálová Lenka   +8 more
doaj   +1 more source

Inhibitory Mechanism of Escherichia coli Adhesion to Caco-2 Monolayers by Polysaccharides from Bangia fusco-purpurea [PDF]

Shipin Kexue
In this study, the effect of Bangia fusco-purpurea polysaccharide (BFP) on Escherichia coli adhesion to Caco-2 monolayers and its potential mechanism was studied using an in vitro human colon adenocarcinoma cell (Caco-2) monolayer model.
DUAN Shushu, ZHENG Mingjing, HONG Tao, ZHU Yanbing, NI Hui, JIANG Zedong
doaj   +1 more source