Results 21 to 30 of about 97,542,255 (296)

Investigation of the transport of lipophilic drugs in structurally diverse lipid formulations through caco-2 cell monolayer using mathematical modeling [PDF]

, 2008
Introduction: To be absorbed from the gastrointestinal tract, a drug has to be sufficiently soluble, because, with some exceptions, passive diffusion of dissolved drug molecules from high to low drug concentration is the driving force of drug ...
Schneider, Marcel
core   +1 more source

In Vitro Toxicity Assessment of Stilbene Extract for Its Potential Use as Antioxidant in the Wine Industry

Antioxidants, 2019
The reduction of sulfur dioxide in wine is a consumer’s demand, considering the allergic effects that may occur in people who are sensitive to it.
Concepción Medrano-Padial, María Puerto, F. Javier Moreno, Tristan Richard, Emma Cantos-Villar, Silvia Pichardo   +5 more
doaj   +1 more source

Changes in Intestinal Permeability Ex Vivo and Immune Cell Activation by Three Commonly Used Emulsifiers

Molecules, 2020
Food additives such as emulsifiers are used in increasing quantities in the food industry. The aim of this study was to compare three different emulsifiers (polysorbate 80 (P80), carboxymethyl cellulose (CMC), and β-lactoglobulin (β-lac) with regards to ...
Elin Oscarsson, Tim Lindberg, Kathrin S. Zeller, Malin Lindstedt, Daniel Agardh, Åsa Håkansson, Karolina Östbring   +6 more
doaj   +1 more source

Interaction of cruciferin-based nanoparticles with Caco-2 cells and Caco-2/HT29-MTX co-cultures

Acta Biomaterialia, 2017
The objective of this work was to assess the potential of Cruciferin/Calcium (Cru/Ca) and Cruciferin/Chitosan (Cru/Cs) nanoparticles for oral drug delivery. For this purpose, Cru/Ca and Cru/Cs nanoparticles were developed through cold gelation of Cruciferin, a major canola protein, and in interaction with calcium and chitosan, respectively.
Ali Akbari, Afsaneh Lavasanifar, Jianping Wu   +2 more
openaire   +2 more sources

Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

Frontiers in Pharmacology, 2022
It is essential to explore the relationship between drugs and transporters in the process of drug development. Strong background signals in nonhuman MDCK or LLC-PK1 cells and overlapping interference of inhibitors or RNAi in human Caco-2 cells mean that ...
Dongyan Feng, Guorui Zhong, Qingxia Zuo, Yanbin Wan, Wanqing Xu, Changsheng He, Cailing Lin, Dongchao Huang, Feng Chen, Lizhen Huang   +9 more
doaj   +1 more source

Eicosapentaenoic acid and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells. [PDF]

, 2006
Stearoyl-CoA desaturase (SCD) is a key enzyme that determines the composition and metabolic fate of ingested fatty acids, in particular the conversion of trans-vaccenic acid (TVA) to conjugated linoleic acid (CLA).
Renaville, B, Mullen, Anne, Anne Mullen, Moloney, F, RENAVILLE, Benedicte France Ghislaine, MOLONEY F, LARONDELLE Y, Helen M. Roche, Molonay, Fiona, Roche, HM, Fiona Moloney, Yvan Larondelle, Mullen, A, Renaville Bénédicte, Moloney, Fiona, Larondelle, Yvan, Yves-Jacques Schneider, MULLEN A, SCHNEIDER YJ ROCHE HM, Roche, Hélèje M., Renaville, Bénédicte, Roche, Helen M, Larondelle, Y, Schneider, Yves-Jacques   +23 more
core   +1 more source

A Cell Co-Culture Taste Sensor Using Different Proportions of Caco-2 and SH-SY5Y Cells for Bitterness Detection

Chemosensors, 2022
Bitter taste receptors (T2Rs) are involved in bitter taste perception, which is one of the five basic taste modalities in mammals. In this study, a cell co-culture taste sensor using different proportions of Caco-2 cells and SH-SY5Y cells was proposed ...
Chunlian Qin, Saisai Zhang, Qunchen Yuan, Mengxue Liu, Nan Jiang, Liujing Zhuang, Liquan Huang, Ping Wang   +7 more
doaj   +1 more source

Mechanistic study of physicochemical and biochemical processes affecting intestinal absorption of the sesquiterpene lactone nobilin from multi-component systems in the Caco-2 model [PDF]

, 2015
The overall aim of this work was to investigate the intestinal absorption of the sesquiterpene lactone nobilin from the flowers of Anthemis nobilis L.
Thormann, U.
core   +1 more source

Coumarins permeability in Caco-2 cell model

Journal of Pharmacy and Pharmacology, 2009
AbstractObjectivesThe presence of coumarins in human diet, their multiple pharma***ćological properties and occurrence in various herbal remedies represent significant reasons to explore their membrane permeability, as a first event contributing to coumarins oral bioavailability.
Anna, Galkin, Adyary, Fallarero, Pia M, Vuorela   +2 more
openaire   +2 more sources

Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats

Pharmaceutics, 2020
Recently, various types of cultured cells have been used to research the mechanisms of transport and metabolism of drugs. Although many studies using cultured cell systems have been published, a comparison of different cultured cell systems has never ...
Tomoyuki Furubayashi, Daisuke Inoue, Noriko Nishiyama, Akiko Tanaka, Reiko Yutani, Shunsuke Kimura, Hidemasa Katsumi, Akira Yamamoto, Toshiyasu Sakane   +8 more
doaj   +1 more source