Results 11 to 20 of about 56,978 (263)

Formulation of a Phenol-Rich Extract from Unripe Olives (Olea europaea L.) in Microemulsion to Improve Its Solubility and Intestinal Permeability

Molecules, 2020
The beneficial properties of phenolic compounds from Olea europaea L. are well-known. An olive extract (OE) was prepared from unripe olives (Moraiolo cultivar). The study aimed to formulate OE into a microemulsion (ME) in oral dosage form.
Lorenzo Cecchi, Vieri Piazzini, Mario D’Ambrosio, Cristina Luceri, Federica Rocco, Marzia Innocenti, Giulia Vanti, Nadia Mulinacci, Maria Camilla Bergonzi   +8 more
doaj   +1 more source

Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability

British Journal of Pharmacy, 2023
The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell, Hannah Batchelor, James Matthew Butler, Ibrahim Khadra, Nena Minstry, Konstantinos Stamatopoulos   +5 more
doaj   +1 more source

Characterization of Acetylcholinesterase in Caco-2 Cells

Experimental Biology and Medicine, 2002
Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) was solubilized from cultured Caco-2 cells. It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-β-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51 ...
Lauren R, Plageman, Giovanni M, Pauletti, Kenneth A, Skau   +2 more
openaire   +2 more sources

Potential capacities of different intestinal epithelial cell lines to form enteroids in 3D culture system: comparison and application

Di-san junyi daxue xuebao, 2020
Objective To compare the potentiality and characteristics of different intestinal epithelial cell (IEC) lines to grow into enteroids when cultured in 3D system in order to provide experimental basis for the cultivation of enteroids by IECs. Methods Three
OU Jing, XU Zhenni, LIU Dengqun
doaj   +1 more source

In Vitro Toxicity Assessment of Stilbene Extract for Its Potential Use as Antioxidant in the Wine Industry

Antioxidants, 2019
The reduction of sulfur dioxide in wine is a consumer’s demand, considering the allergic effects that may occur in people who are sensitive to it.
Concepción Medrano-Padial, María Puerto, F. Javier Moreno, Tristan Richard, Emma Cantos-Villar, Silvia Pichardo   +5 more
doaj   +1 more source

Interaction of cruciferin-based nanoparticles with Caco-2 cells and Caco-2/HT29-MTX co-cultures

Acta Biomaterialia, 2017
The objective of this work was to assess the potential of Cruciferin/Calcium (Cru/Ca) and Cruciferin/Chitosan (Cru/Cs) nanoparticles for oral drug delivery. For this purpose, Cru/Ca and Cru/Cs nanoparticles were developed through cold gelation of Cruciferin, a major canola protein, and in interaction with calcium and chitosan, respectively.
Ali Akbari, Afsaneh Lavasanifar, Jianping Wu   +2 more
openaire   +2 more sources

Changes in Intestinal Permeability Ex Vivo and Immune Cell Activation by Three Commonly Used Emulsifiers

Molecules, 2020
Food additives such as emulsifiers are used in increasing quantities in the food industry. The aim of this study was to compare three different emulsifiers (polysorbate 80 (P80), carboxymethyl cellulose (CMC), and β-lactoglobulin (β-lac) with regards to ...
Elin Oscarsson, Tim Lindberg, Kathrin S. Zeller, Malin Lindstedt, Daniel Agardh, Åsa Håkansson, Karolina Östbring   +6 more
doaj   +1 more source

Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

Frontiers in Pharmacology, 2022
It is essential to explore the relationship between drugs and transporters in the process of drug development. Strong background signals in nonhuman MDCK or LLC-PK1 cells and overlapping interference of inhibitors or RNAi in human Caco-2 cells mean that ...
Dongyan Feng, Guorui Zhong, Qingxia Zuo, Yanbin Wan, Wanqing Xu, Changsheng He, Cailing Lin, Dongchao Huang, Feng Chen, Lizhen Huang   +9 more
doaj   +1 more source

A Cell Co-Culture Taste Sensor Using Different Proportions of Caco-2 and SH-SY5Y Cells for Bitterness Detection

Chemosensors, 2022
Bitter taste receptors (T2Rs) are involved in bitter taste perception, which is one of the five basic taste modalities in mammals. In this study, a cell co-culture taste sensor using different proportions of Caco-2 cells and SH-SY5Y cells was proposed ...
Chunlian Qin, Saisai Zhang, Qunchen Yuan, Mengxue Liu, Nan Jiang, Liujing Zhuang, Liquan Huang, Ping Wang   +7 more
doaj   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source