Results 31 to 40 of about 56,978 (263)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Use of Microarray Datasets to generate Caco-2-dedicated Networks and to identify Reporter Genes of Specific Pathway Activity

Scientific Reports, 2017
Intestinal epithelial cells, like Caco-2, are commonly used to study the interaction between food, other luminal factors and the host, often supported by microarray analysis to study the changes in gene expression as a result of the exposure. However, no
Prashanna Balaji Venkatasubramanian, Gamze Toydemir, Nicole de Wit, Edoardo Saccenti, Vitor A. P. Martins dos Santos, Peter van Baarlen, Jerry M. Wells, Maria Suarez-Diez, Jurriaan J. Mes   +8 more
doaj   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Coumarins permeability in Caco-2 cell model

Journal of Pharmacy and Pharmacology, 2009
AbstractObjectivesThe presence of coumarins in human diet, their multiple pharma***ćological properties and occurrence in various herbal remedies represent significant reasons to explore their membrane permeability, as a first event contributing to coumarins oral bioavailability.
Anna, Galkin, Adyary, Fallarero, Pia M, Vuorela   +2 more
openaire   +2 more sources

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Apoptosis in astrovirus-infected CaCo-2 cells

Virology, 2004
Cell death processes during human astrovirus replication in CaCo-2 cells and their underlying mechanisms were investigated. Morphological and biochemical alterations typical of apoptosis were analyzed in infected cells using a combination of techniques, including DAPI staining, the sub-G(0)/G(1) technique and the TUNEL assay. The onset of apoptosis was
Guix, Susana, Bosch, Albert, Ribes, Enric, Dora Martı́nez, L., Pintó, Rosa M.   +4 more
openaire   +2 more sources

A Fully Defined GelMA‐Based Matrix Allows Fine Tuning of Tissue‐Relevant Biomechanical and Biochemical Cues for Organoid Culture

Advanced Healthcare Materials, EarlyView.
A fully defined GelMA‐based ECM platform integrates tunable tissue‐relevant stiffness with laminin–entactin biochemical supplementation to support mouse small intestinal organoid growth. Coordinated control of mechanical and biochemical cues promotes robust proliferation, budding morphogenesis, differentiation, and passaging, providing a reproducible ...
Junyi Liu, Su Su Htwe, Lay Poh Tan, Yen Choo   +3 more
wiley   +1 more source

Anticancer and anti-inflammatory potentials of doped CuO and ZnO nanoparticles: a multi-pathway mechanistic study

Open Chemistry
This study presents a new dopant-engineered nanotherapeutic approach by directly comparing the biological activities of yttrium-doped copper oxide (Y–CuO) and silver-doped zinc oxide (Ag–ZnO) nanoparticles produced through a controlled co-precipitation ...
Khalifa Mona M., Hussien Nahed Ahmed
doaj   +1 more source

Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression. [PDF]

PLoS ONE, 2014
Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer.
Zhen Liu, Zhi-Jun Duan, Jiu-Yang Chang, Zhi-Feng Zhang, Rui Chu, Yu-Ling Li, Ke-Hang Dai, Guang-Quan Mo, Qing-Yong Chang   +8 more
doaj   +1 more source

Transepithelial Transport of Telmisartan in Caco-2 Monolayers

Biological and Pharmaceutical Bulletin, 2005
Telmisartan is the most recently marketed angiotensin II type 1 receptor antagonist. Drug-drug interactions involving transporters can directly affect the therapeutic safety and efficacy of many important drugs. In clinical practice, telmisartan is coadministered with many kinds of drugs.
Goto, Yoshikazu, Itagaki, Shirou, Umeda, Shinichiro, Kobayashi, Masaki, Hirano, Takeshi, Iseki, Ken, Tadano, Koji   +6 more
openaire   +3 more sources