Results 51 to 60 of about 97,542,255 (296)

dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

Angewandte Chemie, EarlyView.
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng, Tyson D. Todd, Alexandria L. Quillin, Harshad Ingle, Angela M. Halstead, Megan T. Baldridge, José B. Sáenz, Jennifer M. Heemstra   +7 more
wiley   +2 more sources

Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression. [PDF]

PLoS ONE, 2014
Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer.
Zhen Liu, Zhi-Jun Duan, Jiu-Yang Chang, Zhi-Feng Zhang, Rui Chu, Yu-Ling Li, Ke-Hang Dai, Guang-Quan Mo, Qing-Yong Chang   +8 more
doaj   +1 more source

Estimation of the iron bioavailability in green vegetables using an in vitro digestion/Caco-2 cell model [PDF]

, 2019
It is estimated that over 30% of the global population is anaemic, half of which is due to iron deficiency. The bioavailability of iron from vegetables is low and variable, and influenced by food composition and matrix.
Fairweather-Tait, S., Bruggaber, S. F. A, Neal, A. L., Bruggraber, S. F. A., Dellaquila, C., Rodriguez-Ramiro, I., Fairweather-Tail, S., Shewry, P. R., Dell'Aquila, C., Ward, J. L., Ward, Jane, Dellaquila, Cat, Neal, Andy, Shewry, Peter   +13 more
core   +1 more source

Fusing Direct and Indirect Measurements Through Multi‐Fidelity Learning For Accelerated Electrocaloric Materials Discovery

Advanced Science, EarlyView.
A multi‐fidelity framework integrates sparse direct and abundant indirect electrocaloric measurements. Multi‐objective active learning accelerates BaTiO3‐based electrocaloric materials discovery at –70∘C$^{\circ }{\rm C}$. A diffuse transition enables an electrocaloric strength of 0.06×$\times$10−6 Km/V at –70℃ with an operational temperature span of ...
Bo Wang, Pengfei Dang, Yuan Tian, Zhengwang He, Wei Gu, Lixue Zhang, Turab Lookman, Yumei Zhou, Dezhen Xue   +8 more
wiley   +1 more source

Сасо-2 INTESTINAL PERMEABILITY AND Pgp-AFFINITY OF PHOSPHAZIDE

Разработка и регистрация лекарственных средств, 2019
In this work the intestinal permeability of phospazide in vitro was investigated using Caco-2 cell model in apical-basolateral (A-B) and basolateral-apical (B-A) directions as well as with the option of adding of P-glycoprotein (Pgp) inhibitor ...
D. Yu. Grebenkin, Ya. M. Stanishevskiy, I. E. Shohin, A. M. Stoinova, M. A. Karpova, A. G. Koryakova, A. V. Ryabova, B. V. Brovchenko, A. A. Smirnov   +8 more
doaj  

Anticancer and anti-inflammatory potentials of doped CuO and ZnO nanoparticles: a multi-pathway mechanistic study

Open Chemistry
This study presents a new dopant-engineered nanotherapeutic approach by directly comparing the biological activities of yttrium-doped copper oxide (Y–CuO) and silver-doped zinc oxide (Ag–ZnO) nanoparticles produced through a controlled co-precipitation ...
Khalifa Mona M., Hussien Nahed Ahmed
doaj   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Measuring oxygen levels in Caco-2 cultures

Hypoxia, 2015
Measuring oxygen levels in three different systems of Caco-2 cell culture.Caco-2 cells were cultured in three different systems, using conventional polystyrene 24-well plates, special 24-well gas permeable plates, or on membrane inserts in conventional plates.
Zeitouni, Nathalie E., Fandrey, Joachim, Naim, Hassan Y., von Köckritz-Blickwede, Maren   +3 more
openaire   +4 more sources

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Transepithelial Transport of Telmisartan in Caco-2 Monolayers

Biological and Pharmaceutical Bulletin, 2005
Telmisartan is the most recently marketed angiotensin II type 1 receptor antagonist. Drug-drug interactions involving transporters can directly affect the therapeutic safety and efficacy of many important drugs. In clinical practice, telmisartan is coadministered with many kinds of drugs.
Goto, Yoshikazu, Itagaki, Shirou, Umeda, Shinichiro, Kobayashi, Masaki, Hirano, Takeshi, Iseki, Ken, Tadano, Koji   +6 more
openaire   +3 more sources