Results 31 to 40 of about 53,962 (242)

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Uptake of label-free graphene oxide by Caco-2 cells is dependent on the cell differentiation status

Journal of Nanobiotechnology, 2017
Background Understanding the interaction of graphene-related materials (GRM) with human cells is a key to the assessment of their potential risks for human health.
Melanie Kucki, Liliane Diener, Nils Bohmer, Cordula Hirsch, Harald F. Krug, Vincenzo Palermo, Peter Wick   +6 more
doaj   +1 more source

Development of a serum-free co-culture of human intestinal epithelium cell-lines (Caco-2/HT29-5M21)

BMC Cell Biology, 2006
Background The absorptive and goblet cells are the main cellular types encountered in the intestine epithelium. The cell lineage Caco-2 is a model commonly used to reproduce the features of the bowel epithelium.
Schneider Yves-Jacques, Deloyer Patricia, Zorzi Willy, El Moualij Benaïssa, Devillé Christelle, Nollevaux Géraldine, Peulen Olivier, Dandrifosse Guy   +7 more
doaj   +1 more source

Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

Frontiers in Pharmacology, 2022
It is essential to explore the relationship between drugs and transporters in the process of drug development. Strong background signals in nonhuman MDCK or LLC-PK1 cells and overlapping interference of inhibitors or RNAi in human Caco-2 cells mean that ...
Dongyan Feng, Guorui Zhong, Qingxia Zuo, Yanbin Wan, Wanqing Xu, Changsheng He, Cailing Lin, Dongchao Huang, Feng Chen, Lizhen Huang   +9 more
doaj   +1 more source

Inhibition of colorectal cancer cell proliferation, invasion, and migration, and induction of epithelial-mesenchymal transition via TFF1 silencing [PDF]

Vojnosanitetski Pregled
Background/Aim. The identification of aberrant genes associated with colorectal cancer (CRC) and understanding their pathogenic mechanisms are important for early diagnosis and the determination of appropriate therapy.
Zhao Jing, Wang Fan, Li Miao, Liang Rui, Li Changying, Li Menglong, Yalikun Dilimulati, Wang Zhiqiang   +7 more
doaj   +1 more source

MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer.

PLoS ONE, 2016
Mucinous adenocarcinoma (MAC) represents a distinct histopathological entity of colorectal cancer (CRC), which is associated with disease progression and poor prognosis.
Annette Eyking, Henning Reis, Magdalena Frank, Guido Gerken, Kurt W Schmid, Elke Cario   +5 more
doaj   +1 more source

Inhibitory Mechanism of Escherichia coli Adhesion to Caco-2 Monolayers by Polysaccharides from Bangia fusco-purpurea [PDF]

Shipin Kexue
In this study, the effect of Bangia fusco-purpurea polysaccharide (BFP) on Escherichia coli adhesion to Caco-2 monolayers and its potential mechanism was studied using an in vitro human colon adenocarcinoma cell (Caco-2) monolayer model.
DUAN Shushu, ZHENG Mingjing, HONG Tao, ZHU Yanbing, NI Hui, JIANG Zedong
doaj   +1 more source

Identification and Validation of Potential Candidate Genes of Colorectal Cancer in Response to Fusobacterium nucleatum Infection

Frontiers in Genetics, 2021
Objective: Recent investigations revealed the relationship between Fusobacterium nucleatum (Fn) infection and colorectal cancer (CRC). However, how the host genes changes contribute to CRC in response to Fn infection remains largely unknown.Materials and
Jiangguo Zhang, Zhimo Wang, Hong Lv, Guojun Li   +3 more
doaj   +1 more source

Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Brazilian Journal of Medical and Biological Research, 2017
Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types.
S. Zhang, Y. Zhang, J. Qu, X. Che, Y. Fan, K. Hou, T. Guo, G. Deng, N. Song, C. Li, X. Wan, X. Qu, Y. Liu   +12 more
doaj   +1 more source

Caco-2 Cell Line [PDF]

, 2015
The human epithelial cell line Caco-2 has been widely used as a model of the intestinal epithelial barrier. The Caco-2 cell line is originally derived from a colon carcinoma. However, one of its most advantageous properties is its ability to spontaneously differentiate into a monolayer of cells with many properties typical of absorptive enterocytes ...
openaire   +1 more source