Results 21 to 30 of about 120,404,711 (181)

INTESTINAL ABSORPTION AND PRESYSTEMIC DISPOSITION OF SILDENAFIL CITRATE IN THE RABBIT: EVIDENCE FOR SITEDEPENDENT ABSORPTIVE CLEARANCE [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2005
Sildenafil citrate is the first oral treatment of erectile dysfunction. Its oral bioavailability is about 40%. This research characterized the intestinal transport parameters of sildenafil citrate in rabbit using in situ intestinal perfusion technique ...
M. Hedaya, G. El Maghraby, M. Osman
doaj   +1 more source

Bioavailability and biotransformation of benzo(a)pyrene in an isolated perfused In situ catfish intestinal preparation. [PDF]

Environmental Health Perspectives, 1998
In the aquatic environment, diet is an important route of exposure for the common contaminant and procarcinogen benzo(a)pyrene (BaP). Dietary organisms vary in their BaP content and in contaminated areas often contain other xenobiotics including cytochrome P4501A inducers.
K M, Kleinow, M O, James, Z, Tong, C S, Venugopalan   +3 more
openaire   +2 more sources

Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat

Molecules, 2014
Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the
Yan Huo, Yuxing Huang, Xiangmei Hou, Lifeng Han, Lei Wang, Erwei Liu, Xiumei Gao   +6 more
doaj   +1 more source

Antihyperglycemic potential of the Lavandula stoechas aqueous extract via inhibition of digestive enzymes and reduction of intestinal glucose absorption

Journal of Ayurveda and Integrative Medicine, 2023
Background: Diabetes mellitus is a widespread metabolic disorder affecting global populations. Lavandula stoechas from Moroccan traditional medicine is used for its potential anti-diabetic effects.
Amal Elrherabi, Mohamed Bouhrim, Rhizlan Abdnim, Ali Berraaouan, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohamed Bnouham   +7 more
doaj   +1 more source

Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Polyphenols, a group of complex naturally occurring compounds, are widely distributed throughout the plant kingdom and are therefore readily consumed by humans.
Zenghui Teng, Chengjun Yuan, Feng Zhang, Menglei Huan, Weidong Cao, Kangchu Li, Jingyue Yang, Dayong Cao, Siyuan Zhou, Qibing Mei   +9 more
doaj   +1 more source

Etretinate absorption in the in situ perfused intestinal lumen: Preliminary studies in the rat [PDF]

Biopharmaceutics & Drug Disposition, 1991
AbstractThe absorption characteristics of etretinate were examined in the Sprague‐Dawley rat with the use of the in situ intestinal lumen perfusion model. Intestinal segments of 15–50cm were cannulated and perfused with etretinate solutions of 178–1405 μgml−1 in a single‐pass manner at flow rates of 0·15–0·96 ml min−1.
C L, Zimmerman, K E, Johnson
openaire   +2 more sources

Computer-assisted ex vivo, normothermic small bowel perfusion [PDF]

, 2000
Background: In the present study, a technique for computer-assisted, normothermic, oxygenated, ex vivo, recirculating small bowel perfusion was established as a tool to investigate organ pretreatment protocols and ischemia/reperfusion phenomena.
Theodorou, D., Hammer, C., Schildberg, Friedrich Wilhelm, Eder, M., Land, W., Stangl, M. J., Krapp, J.   +6 more
core   +1 more source

Glucose Does Not Facilitate the Absorption of Sorbitol Perfused In Situ in the Human Small Intestine , [PDF]

The Journal of Nutrition, 1997
Sorbitol is better absorbed in the small intestine when ingested concomitantly with glucose. The aim of this study was to test in situ the effect of glucose on the absorption of sorbitol in the human small intestine, using the perfusion technique. The sorbitol absorption of three test solutions, perfused in a random order, was measured in a 30-cm ...
L, Beaugerie, B, Flourié, P, Pernet, L, Achour, C, Franchisseur, J C, Rambaud   +5 more
openaire   +2 more sources

Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models [PDF]

Acta Pharmacologica Sinica, 2012
To investigate the mechanisms underlying the intestinal absorption of the major bioactive component forsythoside A (FTA) extracted from Forsythiae fructus.An in vitro Caco-2 cell model and a single-pass intestinal perfusion in situ model in SD rats were used.In the in vitro Caco-2 cell model, the mean apparent permeability value (P(app)-value) was 4.15×
Wei, Zhou, Liu-qing, Di, Juan, Wang, Jin-jun, Shan, Shi-jia, Liu, Wen-zheng, Ju, Bao-chang, Cai   +6 more
openaire   +2 more sources

Mechanisms of gemcitabine oral absorption as determined by in situ intestinal perfusions in mice

Biochemical Pharmacology, 2019
Gemcitabine is a widely used chemotherapeutic drug that is administered via intravenous infusion due to a low oral bioavailability of only 10%. This low oral bioavailability is believed to be the result of gemcitabine's low intestinal permeability and oral absorption, followed by significant presystemic metabolism.
Brian R. Thompson, Yongjun Hu, David E. Smith   +2 more
openaire   +3 more sources