Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique [PDF]
Pharmaceutics, 2021 Oleacein (OLEA) is one of the most important phenolic compounds in extra virgin olive oil in terms of concentration and health-promoting properties, yet there are insufficient data on its absorption and metabolism.
Anallely López-Yerena +5 more
doaj +6 more sources
Journal of the Formosan Medical Association, 2008 First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was developed for measuring different concentrations of pharmaceuticals in the portal vein and hepatic vein (via the inferior vena cava) for delineating ...
Yunn-Fang Ho +6 more
doaj +4 more sources
FROG INTESTINAL PERFUSION TO EVALUATE DRUG PERMEABILITY: APPLICATION TO P-gp AND CYP3A4 SUBSTRATES [PDF]
Frontiers in Pharmacology, 2015 To evaluate the reliability of using in situ frog intestinal perfusion technique for permeability assessment of carrier transported drugs which are also substrates for CYP enzymes.
Neelima eYerasi +2 more
doaj +2 more sources
In Situ Intestinal Perfusion of Irinotecan: Application to P-gp Mediated Drug Interaction and Introduction of an Improved HPLC Assay [PDF]
Journal of Pharmacy & Pharmaceutical Sciences, 2011 PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotecan, and to quantify the amount of its cytotoxic metabolite SN-38 that is intestinally excreted (exsorped) as a predictor of intestinal toxicity, and to ...
Abdullah Khalil Rabba +4 more
doaj +2 more sources
Synthesis and Evaluation of PEG-PR for Water Flux Correction in an In Situ Rat Perfusion Model
Molecules, 2020 Phenol red (PR) is a widely used marker for water flux correction in studies of in situ perfusion, in which intestinal absorption usually leads to the underestimation of results. In this paper, we propose a novel marker polyethylene glycol (PEG)-PR (i.e.,
Guo Chen +8 more
doaj +2 more sources
Selective evaluation of high density lipoprotein from mouse small intestine by an in situ perfusion technique[S] [PDF]
Journal of Lipid Research, 2014 The small intestine (SI) is the second-greatest source of HDL in mice. However, the selective evaluation of SI-derived HDL (SI-HDL) has been difficult because even the origin of HDL obtained in vivo from the intestinal lymph duct of anesthetized rodents ...
Satoshi Yamaguchi +15 more
doaj +3 more sources
Drug Metabolism and Disposition, 2010 Darunavir is a second-generation protease inhibitor designed to have antiviral efficacy against HIV-1 with multiple resistance mutations to protease inhibitors. It is always coadministered with a subtherapeutic dose of ritonavir. It has been shown that darunavir and ritonavir are substrates of P-glycoprotein (P-gp). We explored the contribution of P-gp
Nico, Holmstock +3 more
openaire +3 more sources
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Dufès, Christine +5 more
core +4 more sources
Effect of berbamine hydrochloride on the absorption of berberine hydrochloride in an in situ single-pass intestinal perfusion system in rats [PDF]
, 2022 Purpose: To investigate the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats.Methods: Based on the in situ single-pass intestinal perfusion model of rats, HPLC was used to determine the ...
Bi, Ruohong +15 more
core +1 more source
Optical Coherence Tomography Imaging of Tissue Engineered Skin Cultured Under Perfusion Conditions [PDF]
, 2013 Tissue engineered (TE) human skin constructs are useful for the investigation of disease pathologies and for exploring the potencies and side effects of medicines and cosmetics.
Robertson, Caroline
core +5 more sources