Results 21 to 30 of about 374,594 (305)

Assessment of contribution of BCRP to intestinal absorption of various drugs using portal‐systemic blood concentration difference model in mice

Pharmacology Research & Perspectives, 2020
Prediction of the intestinal absorption of new chemical entities (NCEs) is still difficult, in part because drug efflux transporters, including breast cancer resistance protein (BCRP) and P‐glycoprotein (P‐gp), restrict their intestinal permeability.
Iichiro Kawahara, Satoyo Nishikawa, Akira Yamamoto, Yusuke Kono, Takuya Fujita   +4 more
doaj   +1 more source

Development of active jejunal glucose absorption in broiler chickens

Poultry Science, 2023
: Growth in chickens, especially meat-type chickens (broilers), is extremely rapid, but studies on the regulatory mechanism of intestinal glucose absorption with growth are few, contradictory, and unclear.
Mikako Shibata, Tatsuyuki Takahashi, Takaharu Kozakai, Junji Shindo, Yohei Kurose   +4 more
doaj   +1 more source

Iron metabolism of in­testinal mucosa in various blood diseases [PDF]

, 1964
For the investigation of iron metabolism in the intestinal mucosa in various　blood diseases, intestinal biopsy (duodenum) was performed on 10 healthy controls　and 35 cases with various blood diseases.
Kimura, Ikuro, Kodani, Hidenari, Tsuchida, Junichiro   +2 more
core   +1 more source

Application of the steady-state intestinal perfusion system in measuring intestinal fluid absorption and bicarbonate secretion in vivo

Frontiers in Physiology, 2023
Background: The steady-state intestinal perfusion system represents a tool used in measuring intestinal fluid absorption and bicarbonate secretion in vivo; however, detailed procedures and parameters were not elucidated fully.Aim: We focused on the ...
Wenjuan Fan, Qinghai Tan
doaj   +1 more source

Increased intestinal carbonate precipitate abundance in the sea bream (Sparus aurata L.) in response to ocean acidification [PDF]

, 2019
Marine fish contribute to the carbon cycle by producing mineralized intestinal precipitates generated as by-products of their osmoregulation. Here we aimed at characterizing the control of epithelial bicarbonate secretion and intestinal precipitate ...
Carvalho, Edison S. M., Fuentes, Juan, Gregorio, Silvia, Ruiz-Jarabo, Ignacio   +3 more
core   +1 more source

Monoglyceride modification of jejunal absorption of fatty acid in the rat

Journal of Lipid Research, 1974
The effect of increasing the intracellular pool of monoolein upon the subsequent uptake and esterification of oleic acid was investigated using in vitro rat jejunal slice techniques.
A. Thomas Marubbio, Jr., John A. Morris, Jr., Susanne Bennett Clark, Peter R. Holt   +3 more
doaj   +1 more source

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. [PDF]

, 2013
ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with ...
Albanese, Anthony, Asmuth, David M, Devaraj, Sridevi, Douek, Daniel C, Flynn, Neil M, Garcia, Juan-Carlos, Knight, Thomas H, Ma, Zhong-Min, Miller, Christopher J, Sandler, Netanya G, Tsuchida, Emily, Wu, Tsung-Teh, Yotter, Tammy   +12 more
core   +1 more source

Intestinal Absorption of Fructose [PDF]

Annual Review of Nutrition, 2018
Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases.
Ronaldo P, Ferraris, Jun-Yong, Choe, Chirag R, Patel   +2 more
openaire   +2 more sources

Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption [PDF]

, 2015
Oral absorption of compounds depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal ...
Alex A. Freitas, Amidon, Artursson, Artursson, Avdeef, Bai, Balaban, Balimane, Bergstrom, Bergstrom, BNF, Boobis, Braun, Breiman, BriskeAnderson, Buckley, CDER/FDA, Chen, Cheng, Chu, Clark, Danielle Newby, Di, Dressman, Egan, Englund, Fagerholm, FDA, Fogh, Gao, Gasteiger, Gertz, Ghafourian, Gres, Hahn, Hayeshi, Hebert, Hidalgo, Hilgendorf, Hilgendorf, Hou, Irvine, Jacobsen, Jain, Le Ferrec, Lin, Lipinski, Lipinski, Matsson, Mehramizi, Merino, Miller, Minuesa, Newby, Newby, Niwa, Pade, Pham-The, Pham-The, Pinto, Quan, Sanghvi, Savjani, Shah, Shugarts, Stegemann, Stenberg, Sugano, Sugano, Taravat Ghafourian, Tavelin, The, Ungell, van Breemen, van de Waterbeemd, Varma, Varma, Varma, Volpe, Wang, Wessel, Yee, Zhao, Zhao   +83 more
core   +2 more sources

Tube choledochoureterostomy: A simple method for bile diversion [PDF]

, 1990
A technique of bile diversion by tube choledochoureterostomy has been devised for the purpose of studying the role of bile in the intestinal absorption of drugs. This method was used in six dogs. No technical difficulties or major complications developed,
Andrews W, Barringer M, Ericzon B G, Hiroyuki Furukawa, Kapsinow R, Knoebel L K, Marshall R W, Oscar Imventarza, Pearce R M, Rous P, Satoru Todo, Thomas E. Starzl, You Min Wu   +12 more
core   +1 more source