The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]
, 2010 pharmaceutic
Lowes, Simon +22 more
core +1 more source
Frontiers in Physiology, 2023 Background: The steady-state intestinal perfusion system represents a tool used in measuring intestinal fluid absorption and bicarbonate secretion in vivo; however, detailed procedures and parameters were not elucidated fully.Aim: We focused on the ...
Wenjuan Fan, Qinghai Tan
doaj +1 more source
The past, present and future of intestinal in vitro cell systems for drug absorption studies.
Journal of Pharmacy and Science, 2020 The intestinal epithelium acts as a selective barrier for the absorption of water, nutrients and orally administered drugs. To evaluate the gastrointestinal permeability of a candidate molecule, scientists and drug developers have a multitude of cell ...
Sonia Youhanna, V. M. Lauschke
semanticscholar +1 more source
Monoglyceride modification of jejunal absorption of fatty acid in the rat
Journal of Lipid Research, 1974 The effect of increasing the intracellular pool of monoolein upon the subsequent uptake and esterification of oleic acid was investigated using in vitro rat jejunal slice techniques.
A. Thomas Marubbio, Jr. +3 more
doaj +1 more source
Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight
Antioxidants, 2017 Vitamin E is an essential fat-soluble micronutrient whose effects on human health can be attributed to both antioxidant and non-antioxidant properties. A growing number of studies aim to promote vitamin E bioavailability in foods.
E. Reboul
semanticscholar +1 more source
Development of active jejunal glucose absorption in broiler chickens
Poultry Science, 2023 : Growth in chickens, especially meat-type chickens (broilers), is extremely rapid, but studies on the regulatory mechanism of intestinal glucose absorption with growth are few, contradictory, and unclear.
Mikako Shibata +4 more
doaj +1 more source
Intestinal absorption of small peptides: a review
International Journal of Food Science & Technology, 2018 Peptides display diverse structural features because of their varied amino acid compositions. The structural diversity often imparts them complex physiological functions, or possible health‐beneficial effects.
Weilin Shen, T. Matsui
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury [PDF]
, 2008 Background A partially hydrolysed and dried product of pacific whiting fish is marketed as a health food supplement supporting 'intestinal health'.Aim To examine whether the partially hydrolysed and dried product of pacific whiting fish influenced the ...
Marchbank, T +4 more
core +1 more source