Results 51 to 60 of about 1,544,258 (252)

Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport ManganeseSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: SLC11A2 (DMT1) and SLC40A1 (ferroportin) are essential for dietary iron absorption, but their role in manganese transport is debated.
Milankumar Prajapati, Jared Z. Zhang, Grace S. Chong, Lauren Chiu, Courtney J. Mercadante, Heather L. Kowalski, Olga Antipova, Barry Lai, Martina Ralle, Brian P. Jackson, Tracy Punshon, Shuling Guo, Mariam Aghajan, Thomas B. Bartnikas   +13 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

eLife
The intestinal absorption of essential nutrients, especially those not readily biosynthesized, is a critical physiological process for maintaining homeostasis.
Yoshihisa Mimura, Tomoya Yasujima, Katsuhisa Inoue, Shogo Akino, Chitaka Namba, Hiroyuki Kusuhara, Yutaro Sekiguchi, Kinya Ohta, Takahiro Yamashiro, Hiroaki Yuasa   +9 more
doaj   +1 more source

Absorption and lymphatic transport of cholesterol and sitosterol in the rat

Journal of Lipid Research, 1969
An attempt was made to determine the mechanism for the greater absorbability of cholesterol as compared to sitosterol.Sitosterol-22,23-3H in different combinations with cholesterol-4-14C, dissolved in 0.8 ml of triolein, was fed to rats with lymph ...
Christer Sylvén, Bengt Borgström
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Metabolic Inhibition Model Which Predicts the Intestinal Absorbability and Metabolizability of Drug: Theory and Experiment

Biological Procedures Online, 1998
The intestinal absorption of analgesic peptides (leucine enkephalin and kyotorphin) and modified peptides in rat were studied. Although these peptides were not absorbed, the absorbability (absorption clearance) of these peptides were increased in the ...
Mizuma Takashi, Awazu Shoji
doaj   +1 more source

Importance of nutritional therapy in the management of intestinal diseases: Beyond energy and nutrient supply

, 2020
The gut is an immune-microbiome-epithelial complex. Gut microbiome-host interactions have widespread biological implications, and the role of this complex system extends beyond the digestion of food and nutrient absorption.
김성은
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Cadmium in the mammary gland and neonatal intestine [PDF]

, 2010
Cadmium is a ubiquitous toxic metal known to cause several adverse health effects in humans. Newborns have an increased gastrointestinal absorption of cadmium compared to adults and seem to be more sensitive to cadmium toxicity.
Öhrvik, Helena
core   +1 more source

Calcium interference with intestinal absorption of manganese

پژوهان, 2014
Background and Objectives: calcium is the most abundant mineral in the body, making up nearly 2% of total body weight. This element has several roles in organisms. Manganese is an essential trace element which is taken part in the structure of some metal
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doaj