Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption. [PDF]
, 2015 Oral absorption depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal absorption ...
Newby, Danielle +6 more
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Mechanistic study of physicochemical and biochemical processes affecting intestinal absorption of the sesquiterpene lactone nobilin from multi-component systems in the Caco-2 model [PDF]
, 2015 The overall aim of this work was to investigate the intestinal absorption of the sesquiterpene lactone nobilin from the flowers of Anthemis nobilis L.
Thormann, U.
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The sweet life: diet sugar concentration influences paracellular glucose absorption [PDF]
, 2008 Small birds and bats face strong selection pressure to digest food rapidly in order to reduce digesta mass carried during flight. One mechanism is rapid absorption of a high proportion of glucose via the paracellular pathway (transfer between epithelial ...
McWhorter, T. +18 more
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Mechanisms of Carotenoid Intestinal Absorption: Where Do We Stand?
Nutrients, 2019 A growing literature is dedicated to the understanding of carotenoid beneficial health effects. However, the absorption process of this broad family of molecules is still poorly understood.
E. Reboul
semanticscholar +1 more source
Intestinal Absorption of Bile Acids in Health and Disease
Comprehensive Physiology, 2019 The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic circulation. The majority of bile acids are actively absorbed via specific transport proteins that are highly expressed in the distal ileum. The uptake of bile
Alexander L. Ticho +4 more
semanticscholar +1 more source
Increasing weaning age of piglets from 4 to 7 weeks reduces stress, increases post-weaning feed intake but does not improve intestinal functionality [PDF]
, 2010 This study tested the hypothesis that late weaning and the availability of creep feed during the suckling period compared with early weaning, improves feed intake, decreases stress and improves the integrity of the intestinal tract.
Hoogendoorn, A. +3 more
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Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?
Advanced Science, 2019 Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility
Sepehr Talebian +10 more
doaj +1 more source
Pharmacology Research & Perspectives, 2020 Prediction of the intestinal absorption of new chemical entities (NCEs) is still difficult, in part because drug efflux transporters, including breast cancer resistance protein (BCRP) and P‐glycoprotein (P‐gp), restrict their intestinal permeability.
Iichiro Kawahara +4 more
doaj +1 more source
Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies
Pharmaceutics, 2023 Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism.
Kazuyoshi Michiba +3 more
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Physiology of Intestinal Absorption and Secretion
Best practice & research. Clinical gastroenterology, 2016 Virtually all nutrients from the diet are absorbed into blood across the highly polarized epithelial cell layer forming the small and large intestinal mucosa.
P. Kiela, F. Ghishan
semanticscholar +1 more source