Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia [PDF]
PharmaceuticalsCytarabine (CTR) is a hydrophilic anticancer drug used to treat leukemia. It suffers from poor permeability and intestinal metabolism, diminishing its oral bioavailability.
Abdelrahman R. Said +4 more
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Effect of luteolin on ceftiofur intestinal absorption: the rational use of Caco-2 monolayer cell model and everted gut sac model [PDF]
Poultry ScienceBackground: The clinical utility of ceftiofur primarily stems from its broad-spectrum antibacterial properties. However, its limited oral bioavailability significantly constrains therapeutic effectiveness.
Ruxia Wang +8 more
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Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells—A Review
International Journal of Molecular Sciences, 2015 Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively ...
Charlotte Grootaert +2 more
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Progress in Research and Application of Intestinal Absorption Cell Models on Carotenoids [PDF]
Shipin Kexue, 2023 Dietary compounds are crucial in maintaining human physiological functions and preventing diseases, but they can give full play to their functional activities only after being effectively absorbed and utilized by the human body.
WU Fan, CHEN Nan, WU Yuqing, NI Yuanying, WEN Xin
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Intestinal absorption and biliary elimination of glycyrrhizic acid diethyl ester in rats
Drug Design, Development and Therapy, 2013 Kenjiro Koga,1 Mayuri Kawamura,1 Hiroshi Iwase,2 Nobuji Yoshikawa31Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, 2Research Division, 3Research and Development Division, Cokey Systems Co, Ltd ...
Koga K, Kawamura M, Iwase H, Yoshikawa N
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Frontiers in Bioengineering and Biotechnology, 2022 Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport.
Arjen Weller +18 more
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Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Dufès, Christine +5 more
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Gels, 2021 Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell ...
Cecilie Hoeeg +2 more
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Vitamin D-Mediated Regulation of Intestinal Calcium Absorption
Nutrients, 2022 Vitamin D is a critical regulator of calcium and bone homeostasis. While vitamin D has multiple effects on bone and calcium metabolism, the regulation of intestinal calcium (Ca) absorption efficiency is a critical function for vitamin D.
J. Fleet
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Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate
FASEB BioAdvances, 2023 Extracellular vesicle (EV) secretion rate is stimulated by hypoxia that causes increased reactive oxygen species (ROS) production by the mitochondrial electron transport chain (ETC) and hypoxia‐induced factor (HIF)‐1 signaling; however, their ...
Mikkel Ø. Nørgård +6 more
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