Results 1 to 10 of about 27,376,677 (317)
Tight junction protein ZO-1 in Kawasaki disease [PDF]
BMC Pediatrics, 2021 Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai +4 more
doaj +4 more sources
ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis [PDF]
Nature CommunicationsZonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions with RNA-binding proteins that are part of stress granules (SGs ...
Yassine El Bakkouri +13 more
doaj +3 more sources
Context-dependent interactions among afadin, ZO-1, and actin filaments [PDF]
Cell Structure and FunctionAfadin and ZO-1 are actin-binding scaffold proteins localized at cell-cell junctions. Although these proteins contain multiple protein-binding motifs for various junctional proteins, their binding partners within cells are strictly regulated.
Yuji Nitta +10 more
doaj +3 more sources
MicroRNA-103 regulates the progression in endometrial carcinoma through ZO-1 [PDF]
International Journal of Immunopathology and Pharmacology, 2019 Endometrial carcinoma (EC) is one of the most common gynecological cancers in many developing countries. Although tremendous advances have been made in the diagnosis and treatment of EC, there is still no adequate biomarker currently available for ...
Jing Du +4 more
doaj +4 more sources
Biomedicines, 2021 Yes-associated protein (YAP) regulates numerous cellular homeostasis processes and malignant transformation. We found that YAP influences ZO-1-mediated cell migration using E-cadherin-restored EC96 cells derived from gastric malignant AGS cells.
Seon-Young Kim +4 more
doaj +2 more sources
Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway. [PDF]
BMC Infect Dis, 2022 Background Neonatal bacterial meningitis is a common neonatal disease with high morbidity, and can cause serious sequelae when left untreated. Escherichia coli is the common pathogen, and its endotoxin, lipopolysaccharide (LPS) can damage the endothelial
Zou P +7 more
europepmc +2 more sources
Tight junction proteins occludin and ZO-1 as regulators of epithelial proliferation and survival. [PDF]
Ann N Y Acad Sci, 2022 Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of epithelial cells must establish a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing the leakage of potentially ...
Kuo WT, Odenwald MA, Turner JR, Zuo L.
europepmc +2 more sources
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction [PDF]
Circulation Research, 2020 Supplemental Digital Content is available in the text. Rationale: ZO-1 (Zona occludens 1), encoded by the tight junction protein 1 (TJP1) gene, is a regulator of paracellular permeability in epithelia and endothelia.
Wenli Dai +21 more
semanticscholar +3 more sources
Cells, 2022 Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how tight ...
Alexis J. Haas +8 more
doaj +2 more sources
Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance [PDF]
Biomedicines, 2023 (1) Introduction: Claudin-9 (CLDN9) is a member of the claudin protein family, a critical transmembrane protein family for tight junctions that are implemented in the progression of numerous cancer types.
Xinguo Zhuang +8 more
doaj +2 more sources