Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice [PDF]
Cell Structure and FunctionThe liver is a complex organ with a highly organized structure in which tight junctions (TJs) play an important role in maintaining their function by regulating barrier properties and cellular polarity.
Masahiko Itoh +3 more
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Polyubiquitination and SUMOylation Sites Regulate the Stability of ZO-2 Protein and the Sealing of Tight Junctions [PDF]
Cells, 2022 Tight junctions (TJs) regulate the transit of ions and molecules through the paracellular pathway in epithelial cells. Zonula occludens 2 (ZO-2) is a cytoplasmic TJ protein.
Misael Cano-Cortina +4 more
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p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP [PDF]
Cell Reports, 2023 Summary: ARHGAP35, which encodes p190A RhoGAP (p190A), is a major cancer gene. p190A is a tumor suppressor that activates the Hippo pathway. p190A was originally cloned via direct binding to p120 RasGAP (RasGAP).
Hanyue Ouyang +5 more
doaj +6 more sources
A direct interaction of JAM-C with the tight junction scaffold protein ZO-2 [PDF]
Scientific ReportsTight junctions are sites of cell-cell contacts at the apical region of epithelial junctions that are involved in barrier formation, cellular signaling, and cell-cell adhesion.
Annika Schulte +7 more
doaj +3 more sources
ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration [PDF]
iScienceSummary: Tight junction protein-1 and -2 (Tjp1/ZO-1 and Tjp2/ZO-2) function as scaffold proteins within the tight junction complexes of the blood-retinal barrier (BRB). Although the breakdown of the BRB is implicated in retinopathies, the contribution of
Safiah Mohamed Ali +20 more
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ZO-2 seals the deal for platelet tight junctions [PDF]
Research and Practice in Thrombosis and HaemostasisYiheng Zhang +2 more
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Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD. [PDF]
Mol Biol Cell, 2021 ZO-2 interaction with TEAD regulates TEAD movement in and out of the nucleus. nPKCδ blocks formation of ZO-2/TEAD complex. PKA blocks ZO-2 nuclear import. nPKCε activates a NES of ZO-2 and TEAD exportation in a complex with ZO-2 or alone.
Gallego-Gutiérrez H +4 more
europepmc +4 more sources
ZO-2 determines cell membrane localization of receptor NTCP and supports hepatitis B virus infection [PDF]
mBioHepatitis B virus (HBV) infects hepatocytes by using sodium taurocholate cotransporting polypeptide (NTCP) as a receptor. NTCP can render non-permissive hepatocyte cell lines such as HepG2 permissive to HBV infection.
Hironori Nishitsuji +8 more
doaj +2 more sources
Contact and communication: ZO-2 and the Hippo pathway. [PDF]
FEBS JThe PDZ domain‐containing protein ZO‐2 is defined as a tight junction (TJ) protein, but is also known to have a role in the maintenance of cellular apicobasal polarity and to function as a signalling molecule in several pathways, including the Hippo pathway. In this issue, Liu OX et al. [(2024) FEBS J, https://doi.org/10.1111/febs.17304] report how the
Thomas M.
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SUMOylation regulates the intracellular fate of ZO-2. [PDF]
Cell Mol Life Sci, 2017 The zonula occludens (ZO)-2 protein links tight junctional transmembrane proteins to the actin cytoskeleton and associates with splicing and transcription factors in the nucleus. Multiple posttranslational modifications control the intracellular distribution of ZO-2.
Wetzel F +7 more
europepmc +3 more sources