Cingulin Contains Globular and Coiled-Coil Domains and Interacts with Zo-1, Zo-2, Zo-3, and Myosin [PDF]
The Journal of Cell Biology, 1999 We characterized the sequence and protein interactions of cingulin, an Mr 140–160-kD phosphoprotein localized on the cytoplasmic surface of epithelial tight junctions (TJ). The derived amino acid sequence of a full-length Xenopus laevis cingulin cDNA shows globular head (residues 1–439) and tail (1,326–1,368) domains and a central α-helical rod domain (
CORDENONSI, MICHELANGELO +6 more
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Morphology-driven zinc oxide biointeractive carriers with biological barrier modulating effects for pulmonary delivery of liraglutide [PDF]
Journal of NanobiotechnologyPulmonary delivery provides a noninvasive route for systemic administration of biologics, yet efficient lung deposition and permeation across pulmonary barriers remain major challenges.
Jin-Hyuk Jeong +4 more
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Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients [PDF]
PeerJ, 2022 Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR ...
Che Othman Siti Sarah +4 more
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Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins.
Nafiseh Pakravan +2 more
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Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia
Cells, 2021 MAGUK protein ZO-2 is present at tight junctions (TJs) and nuclei. In MDCK ZO-2 knockdown (KD) cells, nuclei exhibit an irregular shape with lobules and indentations.
Christian Hernández-Guzmán +4 more
doaj +1 more source
Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology [PDF]
Journal of Applied Oral Science, 2021 Bio-C Pulpecto (Bio-CP) was recently developed as the first bioceramic root filling material for primary teeth. Objective To evaluate the physicochemical properties of radiopacity, setting time, pH, cytocompatibility and potential of Bio-CP to induce ...
Victor Manuel OCHOA RODRÍGUEZ +5 more
doaj +1 more source
Anti-Inflammatory Activity of Essential Oil from Zingiber ottensii Valeton in Animal Models
Molecules, 2022 Zingiber ottensii (ZO) Valeton, a local plant in Northern Thailand, has been widely used in traditional medicine. Many studies using in vitro models reveal its pharmacological activities, including the anti-inflammatory activity of ZO essential oil ...
Wisit Thitinarongwate +4 more
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hScrib interacts with ZO‐2 at the cell–cell junctions of epithelial cells [PDF]
FEBS Letters, 2005 In Drosophila, the tumor suppressor Scribble is localized at the septate junctions of epithelial cells. Its mammalian homologue, hScrib, is a basolateral protein likely associated to proteins of the cell–cell junctions. We report the direct interaction between hScrib and ZO‐2, a junction‐associated protein. This interaction relies on two PDZ domains of
Métais, Jean-Yves +4 more
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ZO-1 and ZO-2 are required for extra-embryonic endoderm integrity, primitive ectoderm survival and normal cavitation in embryoid bodies derived from mouse embryonic stem cells. [PDF]
PLoS ONE, 2014 The Zonula Occludens proteins ZO-1 and ZO-2 are cell-cell junction-associated adaptor proteins that are essential for the structural and regulatory functions of tight junctions in epithelial cells and their absence leads to early embryonic lethality in ...
Dominic C Y Phua +5 more
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Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis [PDF]
PeerJ, 2020 Allergic rhinitis (AR) is a common disease affecting 400 million of the population worldwide. Nasal epithelial cells form a barrier against the invasion of environmental pathogens. These nasal epithelial cells are connected together by tight junction (TJ)
Che Othman Siti Sarah +3 more
doaj +2 more sources