Results 11 to 20 of about 17,751,190 (266)

ZO-2 Is a Master Regulator of Gene Expression, Cell Proliferation, Cytoarchitecture, and Cell Size. [PDF]

Int J Mol Sci, 2019
ZO-2 is a cytoplasmic protein of tight junctions (TJs). Here, we describe ZO-2 involvement in the formation of the apical junctional complex during early development and in TJ biogenesis in epithelial cultured cells. ZO-2 acts as a scaffold for the polymerization of claudins at TJs and plays a unique role in the blood–testis barrier, as well as at TJs ...
González-Mariscal L, Gallego-Gutiérrez H, González-González L, Hernández-Guzmán C.   +3 more
europepmc   +4 more sources

Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2

BMC Cell Biology, 2007
Background Tight junctions are required for epithelial barrier formation and participate in the regulation of signalling mechanisms that control proliferation and differentiation.
Balda Maria S, Sanchez-Heras Elena, Aijaz Saima, Matter Karl   +3 more
doaj   +2 more sources

ZO-2/Tjp2 suppresses Yap and Wwtr1/Taz-mediated hepatocyte to cholangiocyte transdifferentiation in the mouse liver. [PDF]

NPJ Regen Med, 2022
AbstractTJP2/ZO-2-inactivating mutations in humans cause progressive cholestatic liver disease. Liver-specific deletion of Tjp2 in the mouse (Tjp2 cKO mice) leads to mild progressive cholestasis without an overt degradation of the bile-blood barrier (BBB). These mice are more susceptible to cholic acid (CA) induced liver injury.
Xu J, Kausalya PJ, Ong AGM, Goh CMF, Mohamed Ali S, Hunziker W.   +5 more
europepmc   +4 more sources

Rotenone inhibited osteosarcoma metastasis by modulating ZO-2 expression and location via the ROS/Ca2+/AMPK pathway [PDF]

Redox Report
Background Pulmonary metastases in osteosarcoma (OS) are associated with a poor prognosis. Rotenone has shown anti-cancer activity. However, its effects on metastasis and the underlying mechanisms remain unknown. This study investigated the potential use
Xiang Ma, Zhen Li, Hengwei Ma, Kun Jiang, Bao Chen, Weiquan Wang, Ziqiang Zhu, Jianqiang Wang, Zuozhang Yang, Wang Yunqing, Suwei Dong   +10 more
doaj   +2 more sources

Beyond cell-cell adhesion [PDF]

Tissue Barriers, 2013
Zonula occludens proteins (ZO-1, ZO-2, ZO-3), which belong to the family of membrane-associated guanylate kinase (MAGUK) homologs, serve as molecular hubs for the assembly of multi-protein networks at the cytoplasmic surface of intercellular contacts in epithelial and endothelial cells. These multi-PDZ proteins exert crucial functions in the structural
Traweger, Andreas, Toepfer, Sebastian, Wagner, Roland N., Zweimueller-Mayer, Josef, Gehwolf, Renate, Lehner, Christine, Tempfer, Herbert, Krizbai, Istvan, Wilhelm, Imola, Bauer, Hans-Christian, Bauer, Hannelore   +10 more
openaire   +3 more sources

PARP‑1 may be involved in hydroquinone‑induced apoptosis by poly ADP‑ribosylation of ZO‑2. [PDF]

Mol Med Rep, 2017
Hydroquinone (HQ), a major reactive metabolite of benzene, contributes to benzene‑induced leukemia. The molecular mechanisms that underlie this activity remain to be elucidated. Poly ADP‑ribosylation (PARylation) is a type of reversible posttranslational modification that is performed by enzymes in the PAR polymerase (PARP) family and mediates ...
Liu J, Yuan Q, Ling X, Tan Q, Liang H, Chen J, Lin L, Xiao Y, Chen W, Liu L, Tang H.   +10 more
europepmc   +4 more sources

Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells. [PDF]

PLoS ONE, 2017
Claudin-2, ZO-1, and occludin are major components of tight junctions (TJs) in the proximal tubule. However, their roles in maintaining paracellular permeability as leaky epithelia have yet to be defined.To investigate the contributory role of TJ ...
Sua Kim, Gheun-Ho Kim
doaj   +2 more sources

Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules [PDF]

Kidney International, 2000
Tight junctions play a critical role in tubular function. In mammalian kidney, the transepithelial electrical resistance and the complexity of the tight junction increase from the proximal to the collecting tubule. The differential expression of three tight junction proteins, ZO-1, ZO-2, and occludin, along isolated rabbit renal tubules is examined in ...
L, Gonzalez-Mariscal, M C, Namorado, D, Martin, J, Luna, L, Alarcon, S, Islas, L, Valencia, P, Muriel, L, Ponce, J L, Reyes   +9 more
openaire   +3 more sources

ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation [PDF]

Cell, 2006
A fundamental question in cell and developmental biology is how epithelial cells construct the diffusion barrier allowing them to separate different body compartments. Formation of tight junction (TJ) strands, which are crucial for this barrier, involves the polymerization of claudins, TJ adhesion molecules, in temporal and spatial manners. ZO-1 and ZO-
Umeda, Kazuaki, Ikenouchi, Junichi, Katahira-Tayama, Sayaka, Furuse, Kyoko, Sasaki, Hiroyuki, Nakayama, Mayumi, Matsui, Takeshi, Tsukita, Sachiko, Furuse, Mikio, Tsukita, Shoichiro   +9 more
openaire   +3 more sources

Subcellular Distribution of Tight Junction-Associated Proteins (Occludin, ZO-1, ZO-2) in Rodent Skin [PDF]

Journal of Investigative Dermatology, 1998
Occludin is an integral membrane protein that is concentrated at tight junctions (zonulae occludentes) in simple epithelial cells. ZO-1 and ZO-2 are peripheral membrane proteins that are localized at tight junctions in simple epithelial cells and at cadherin-based adherens junctions in nonepithelial cells.
Morita, Kazumasa, Itoh, Masahiko, Saitou, Mitinori, Ando-Akatsuka, Yuhko, Furuse, Mikio, Yoneda, Kozo, Imamura, Sadao, Fujimoto, Kazushi, Tsukita, Shoichiro   +8 more
openaire   +3 more sources