Results 31 to 40 of about 24,539,782 (228)

Spatial Overlap of Claudin- and Phosphatidylinositol Phosphate-Binding Sites on the First PDZ Domain of Zonula Occludens 1 Studied by NMR

Molecules, 2018
Background: The tight junction is an intercellular adhesion complex composed of claudins (CLDs), occludin, and the scaffolding proteins zonula occludens 1 (ZO-1) and its two paralogs ZO-2 and ZO-3.
Hidekazu Hiroaki, Kaori Satomura, Natsuko Goda, Yukako Nakakura, Minami Hiranuma, Takeshi Tenno, Daizo Hamada, Takahisa Ikegami   +7 more
doaj   +1 more source

Differential adhesion molecule expression during murine embryonic stem cell commitment to the hematopoietic and endothelial lineages. [PDF]

PLoS ONE, 2011
Mouse embryonic stem cells (ESC) make cell fate decisions based on intrinsic and extrinsic factors. The decision of ESC to differentiate to multiple lineages in vitro occurs during the formation of embryoid bodies (EB) and is influenced by cell ...
Basha L Stankovich, Esmeralda Aguayo, Fatima Barragan, Aniket Sharma, Maria G Pallavicini   +4 more
doaj   +1 more source

Establishment of an oligoasthenospermia mouse model based on TAp73 gene suppression

Animal Models and Experimental Medicine, 2021
Background Oligoasthenospermia is one of the main causes of male infertility. Researchers usually use chemical drugs to directly damage germ cells to prepare oligoasthenospermia models, which disregards the adhesion and migration between spermatogenic ...
Hong‐Juan Liu, Meng‐Yun Deng, Yan‐Yan Zhu, De‐Ling Wu, Xiao‐Hui Tong, Li Li, Lei Wang, Fei Xu, Tong‐Sheng Wang   +8 more
doaj   +1 more source

Essential Oil from Zingiber ottensii Induces Human Cervical Cancer Cell Apoptosis and Inhibits MAPK and PI3K/AKT Signaling Cascades

Plants, 2021
Zingiber ottensii (ZO) is a local plant in Thailand and has been used as a Thai traditional therapy for many conditions. ZO has been reported to exhibit many pharmacological effects, including anti-cancer activity.
Jirapak Ruttanapattanakul, Nitwara Wikan, Kittinan Chinda, Thanathorn Jearanaikulvanich, Napatsorn Krisanuruks, Muantep Muangcha, Siriporn Okonogi, Saranyapin Potikanond, Wutigri Nimlamool   +8 more
doaj   +1 more source

The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB [PDF]

, 2006
The tight junction adaptor protein ZO-1 regulates intracellular signaling and cell proliferation. Its Src homology 3 (SH3) domain is required for the regulation of proliferation and binds to the Y-box transcription factor ZO-1-associated nucleic acid ...
Balda, MS, Matter, K, Tsapara, A
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Investigating the Aerodynamic Surface Roughness Length over Baghdad City Utilizing Remote Sensing and GIS Techniques

مجلة بغداد للعلوم, 2021
This study calculated the surface roughness length (Zo), zero-displacement length (Zd) and height of the roughness elements (ZH) using GIS applications. The practical benefit of this study is to classify the development of Baghdad, choose the appropriate
Al-Zahraa A. Mohsen , Monim H. Al-Jiboori, Yaseen K. Al-Timimi   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

ZO-1 represents a critical component for cone rearrangement in RP retina.

, 2016
Whole-mounts for M-opsin (red) and ZO-1 (green) immunohistochemical staining in P50 RP retinas treated with non-targeted siRNA (A-D) and ZO-1 siRNA (25uM, E-H) for 24 hrs.
Cheryl Mae Craft (3179256), Divya Nair (3179268), Norberto M. Grzywacz (3179259), Eun-Jin Lee (2299186), Yun Sung Eom (3179274), Jung-A Shin (3179265), Sara X. Z. Grzywacz (3179271), Wan-Qing Yu (3179262)   +7 more
core   +1 more source