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Tight junction physiology of pleural mesothelium [PDF]
Frontiers in Physiology, 2014 Pleura consists of visceral and parietal cell layers, producing a fluid, which is necessary for lubrication of the pleural space. Function of both mesothelial cell layers is necessary for the regulation of a constant pleural fluid volume and composition ...
Alexander G. Markov, Salah eAmasheh
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Toxics, 2022 Inflammation leads to porcine tight junction disruption of small intestinal epithelial cells, resulting in intestinal dysfunction. Herein, we established lipopolysaccharide (LPS)-induced in-vivo and in-vitro inflammatory models. The results revealed that
Jian Kang +6 more
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Tight junctions at a glance [PDF]
Journal of Cell Science, 2008 Tight junctions (TJs) are morphologically distinct and highly regulated areas of close contact between the plasma membranes of neighbouring epithelial and endothelial cells. They are the most apical component of the epithelial junctional complex (which also includes adherens junctions and ...
Maria S, Balda, Karl, Matter
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Frontiers in Physiology, 2020 The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding neurotoxic substances from the peripheral circulation.
Jeffrey J. Lochhead +3 more
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Neurobiology of Disease, 2023 Cerebral cavernous malformation type-3 (CCM3) is a type of brain vascular malformation caused by mutations in programmed cell death protein-10 (PDCD10).
Chelsea M. Phillips +4 more
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STAT3 pathway is involved in interleukin-22 promoting expression of tight junction protein in human colorectal cancer cell line HT29 [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate the effect of interleukin-22(IL-22) on intestinal epithelial barrier tight junction and its mechanism. Methods Human colon cancer HT29 cells were divided into control group, IL-22 group(100 ng/mL), FLLL32 group(pretreatment ...
SONG Qian, HUANG Xue, QIN Meng-bin, ZHANG Jun-hong, JING Jie, LUO Yi-hua, LI Yu-xin
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Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]
, 2016 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
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Developmental expression of claudins in the mammary gland [PDF]
, 2017 Claudins are a large family of membrane proteins whose classic function is to regulate the permeability of tight junctions in epithelia. They are tetraspanins, with four alpha-helices crossing the membrane, two extracellular loops, a short cytoplasmic N ...
Baumgartner, Heidi K. +8 more
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PLoS ONE, 2022 Blood Brain Barrier (BBB) breakdown is a secondary form of brain injury which has yet to be fully elucidated mechanistically. Existing research suggests that breakdown of tight junction proteins between endothelial cells is a primary driver of increased ...
Preston Stafford +8 more
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Cells, 2022 Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how tight ...
Alexis J. Haas +8 more
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