Results 1 to 10 of about 632,604 (307)

Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components

Frontiers in Physiology, 2018
Tight junctions seal off physical barriers, regulate fluid and solute flow, and protect the endoneurial microenvironment of the peripheral nervous system. Physical barriers in the peripheral nervous system were disrupted after nerve injury.
Xinghui Wang, Yang Miao, Jun Ni, Yaxian Wang, Tianmei Qian, Jun Yu, Qianyan Liu, Pan Wang, Sheng Yi   +8 more
doaj   +1 more source

Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. [PDF]

PLoS ONE, 2015
Tight junctions are complex membrane structures that regulate paracellular movement of material across epithelia and play a role in cell polarity, signaling and cytoskeletal organization.
Karin Fredriksson, Christina M Van Itallie, Angel Aponte, Marjan Gucek, Amber J Tietgens, James M Anderson   +5 more
doaj   +1 more source

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

Cell Reports, 2017
Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly ...
Sarah E. Lutz, Julian R. Smith, Dae Hwan Kim, Carl V.L. Olson, Kyle Ellefsen, Jennifer M. Bates, Sunil P. Gandhi, Dritan Agalliu   +7 more
doaj   +1 more source

Structural dynamics of tight junctions modulate the properties of the epithelial barrier.

PLoS ONE, 2019
Tight junctions are dynamic structures that are crucial in establishing the diffusion and electrical barrier of epithelial monolayers. Dysfunctions in the tight junctions can impede this barrier function and lead to many pathological conditions ...
Aapo Tervonen, Teemu O Ihalainen, Soile Nymark, Jari Hyttinen   +3 more
doaj   +1 more source

Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. [PDF]

PLoS ONE, 2017
SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types.
Karin Fredriksson-Lidman, Christina M Van Itallie, Amber J Tietgens, James M Anderson   +3 more
doaj   +1 more source

Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies

Molecules, 2023
Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a critical event that leads to microbe entry and promotes inflammatory responses.
Vishnu Raj, Balaji Venkataraman, Shreesh K. Ojha, Saeeda Almarzooqi, Veedamali S. Subramanian, Basel K. Al-Ramadi, Thomas E. Adrian, Sandeep B. Subramanya   +7 more
doaj   +1 more source

Syndecan-1 Shedding by Matrix Metalloproteinase-9 Signaling Regulates Alveolar Epithelial Tight Junction in Lipopolysaccharide-Induced Early Acute Lung Injury

Journal of Inflammation Research, 2021
Dong Zhang,1 Jin-tao Zhang,1 Yun Pan,1 Xiao-fei Liu,1 Jia-wei Xu,2 Wen-jing Cui,1 Xin-rui Qiao,1 Liang Dong1,2 1Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China ...
Zhang D, Zhang JT, Pan Y, Liu XF, Xu JW, Cui WJ, Qiao XR, Dong L   +7 more
doaj  

The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell—Cell Junctions of Epithelial Cells

Cells, 2022
Transmembrane proteins of adherens and tight junctions are known targets for viruses and bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of epithelial cells, but it is not clear whether ACE2 is localized at apical
Florian Rouaud, Isabelle Méan, Sandra Citi   +2 more
doaj   +1 more source

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

BMC Microbiology, 2010
Background Intestinal barrier function is important for preserving health, as a compromised barrier allows antigen entry and can induce inflammatory diseases.
McCann Mark J, Park Zaneta, McNabb Warren C, Cookson Adrian L, Anderson Rachel C, Kelly William J, Roy Nicole C   +6 more
doaj   +1 more source

Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling

Current Research in Pharmacology and Drug Discovery
Intestinal tight junction disruption contributes to the pathogenesis of inflammatory bowel diseases (IBD). We have recently reported that gallic acid was able to enhance intestinal tight junction assembly via CaMKK-β/AMPK/SIRT-1/ERK-dependent mechanisms ...
Apiwan Arinno, Pichayapa Sukmak, Purisha Kulworasreth, Thaniya Sricharunrat, Chutima S. Vaddhanaphuti, Pawin Pongkorpsakol   +5 more
doaj   +1 more source