Results 1 to 10 of about 681,385 (297)

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation [PDF]

, 2016
Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS.
Arie Reijerkerk, Cheng W., Helga E. Vries, Heusschen R., Ignacio Andres Romero, Miguel Alejandro Lopez‐Ramirez, Waig S.   +6 more
core   +3 more sources

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source

Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

Real-time monitoring of human blood-brain barrier disruption [PDF]

, 2017
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion of hyperosmolar mannitol improves the outcome in primary central nervous system lymphoma.
Alahuhta, Seppo, Isokangas, Matti, Keinanen, Tuija, Kiviniemi, Vesa, Korhonen, Vesa, Kortelainen, Jukka, Kuittinen, Outi, Myllyla, Teemu, Nikkinen, Juha, Rytky, Seppo, Siniluoto, Topi, Sonkajarvi, Eila, Tervonen, Osmo, Tuovinen, Timo, Turpeenniemi-Hujanen, Taina, Voipio, Juha   +15 more
core   +2 more sources

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction [PDF]

, 2016
Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and ...
Abraham, Ahdieh, Ahles, Ahles, Al-Dasooqi, Al-Dasooqi, Al-Dasooqi, Alkam, Argaw, Argaw, Asahi, Ashburner, Bauer, Bercik, Blanco, Bona, Bourke, Boussios, Bowen, Bower, Brown, Brown, Brown, Caliceti, Capuron, Chen, Cheng, Chidlow, Chodobski, Collado-Hidalgo, Corps, Cummins, D'Alessio, Dantzer, Deprez, Deprez, Dietrich, Dietrich, Dietrich, Ferguson, Frank, Gahtan, Galvez, Gangloff, Gatti, Genschaft, Ginos, Goehler, Guo, Han, Henriksen, Higashida, Hjermstad, Holden, Holmes, Horky, in't Veld, Inagaki, Janelsins, Jenkins, Jenkins, Jiao, Jickling, Komaki, Krabbe, Krabbe, Laye, Lepage, Li, Lischper, Liu, Logan, Logan, McDonald, McDonald, Meyers, Minter, Mustian, Natah, Nokia, Nyuyki, Pan, Pan, Papadakis, Patel, Proescholdt, Quan, Riazi, Rochfort, Rodriguez, Roque, Schreibelt, Seigers, Seigers, Sharma, Sharma, Sharma, Simo, Sodeck, Sonis, Sparkman, Stringer, Stringer, Tannock, Trask, Vardy, Vermeer, Villena, Vink, Vries, Wang, Wardill, Wardill, Wardill, Wardill, Wardill, Wardill, Wardill, Wong, Wu, Zonis   +120 more
core   +1 more source

Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective

Frontiers in Pharmacology, 2019
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie, Luca Cucullo, Luca Cucullo   +2 more
doaj   +1 more source

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke. [PDF]

, 2016
Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications ...
Adibhatla, Agrawal, Alcaide, Amantea, Amantea, Anthony, Asahi, Asahi, Asahi, Bajor, Bakowski, Bauer, Benarroch, Burk, Candelario-Jalil, Carbone, Castellanos, Castellanos, Chang, Chesler, Choi, Clark, Clark, Conant, Copin, Cuadrado, Cuadrado, Cunningham, Dejonckheere, Fanjul-Fernández, Fernandez-Patron, Ferry, Fiorelli, Frank R. Sharp, Fujimoto, Fujimura, Fujimura, Gasche, Gasche, Gasche, Gautier, Gidday, Golab, Gu, Gurney, Gürsoy-Ozdemir, Hacke, Harris, Heo, Heo, Horstmann, Hu, Inzitari, Jickling, Justicia, Keck, Kelly, Khandoga, Kim, Kuroiwa, Kurzepa, Lapchak, Lee, Lenglet, Lenglet, Li, Lucivero, Lukes, Lynch, Machado, Maier, Manabe, McCarthy, Moldes, Montaner, Montaner, Montaner, Montaner, Montaner, Montaner, Mun-Bryce, Murata, Nguyen, Ning, Oda, Opdenakker, Orbe, Piccardi, Planas, Ra, Ramos-Fernandez, Ranasinghe, Renée J. Turner, Reynolds, Rivera, Rodrigues, Rodríguez, Rodríguez-Yáñez, Romanic, Rosell, Rosell, Rosell, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Sandoval, Schnoor, Shigemori, Si-Tayeb, Sotgiu, Steadman, Sternlicht, Sumii, Svedin, Tan, Tang, Tsuji, Tsuruoka, Turba, Van den Steen, Vandooren, Vukasovic, Wang, Wang, Wang, Yan, Yang, Yang, Yushchenko, Zhao, Zhao, Zhao, Zozulya   +133 more
core   +6 more sources

Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V

Molecules, 2015
α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch, Jorick Vanbeselaere, Clément P. Delannoy, Aurore Drolez, Caroline Mysiorek, Yann Guérardel, Philippe Delannoy, Sylvain Julien   +7 more
doaj   +1 more source

Ammonia : this is not the end but rather the end of the beginning [PDF]

, 2018
Hepatic encephalopathy (HE) represents a wide spectrum of neurological or neuropsychological symptoms caused by liver disease and/or portosystemic shunts.
Dam, Gitte, Rose, Christopher, Weiss, Nicolas   +2 more
core   +1 more source

Cannabinoids, Blood–Brain Barrier, and Brain Disposition

Pharmaceutics, 2020
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds.
Fabrizio Calapai, Luigi Cardia, Emanuela Elisa Sorbara, Michele Navarra, Sebastiano Gangemi, Gioacchino Calapai, Carmen Mannucci   +6 more
doaj   +1 more source