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Development of the blood-brain barrier. [PDF]

Development
ABSTRACT The blood–brain barrier (BBB) is a term used to describe the specialized properties of vasculature in the central nervous system (CNS) that regulate the exchange of ions, molecules and cells, thereby maintaining CNS homeostasis.
Gastfriend BD, Daneman R.
europepmc   +3 more sources

The blood–brain barrier

Neurobiology of Disease, 2010
Alan M. Palmer
doaj   +3 more sources

Blood brain barrier opening is not just blood-brain barrier opening

Journal of Translational Medicine
Deepa Sharma, Gregory J. Czarnota
doaj   +3 more sources

Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27

Biology, 2023
Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses.
Camille Menaceur, Océane Dusailly, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol   +4 more
doaj   +1 more source

Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics

Cells, 2023
Within the neurovascular unit, brain pericytes (BPs) are of major importance for the induction and maintenance of the properties of the blood-brain barrier (BBB) carried by the brain microvessel endothelial cells (ECs).
Camille Menaceur, Johan Hachani, Shiraz Dib, Sophie Duban-Deweer, Yannis Karamanos, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol   +9 more
doaj   +1 more source

Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE

Journal of Neuroinflammation, 2021
Background Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular ...
Dylan Krajewski, Debayon Paul, Shujun Ge, Evan Jellison, Joel S. Pachter   +4 more
doaj   +1 more source

RETRACTED ARTICLE: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Stem Cell Research & Therapy, 2021
Background Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term.
Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell, Fabien Gosselet   +14 more
doaj   +1 more source

Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?

Physiological Reports, 2021
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming socioeconomic impact.
Vardan T. Karamyan
doaj   +1 more source

The Blood–Brain Barrier [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood-brain barrier, which allow these vessels to tightly regulate the movement of ions, molecules, and cells between the blood and the
Richard, Daneman, Alexandre, Prat
openaire   +2 more sources

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model

Fluids and Barriers of the CNS, 2019
Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang, Joel S. Pachter   +5 more
doaj   +1 more source