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Cold Spring Harbor Perspectives in Biology, 2015 Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood-brain barrier, which allow these vessels to tightly regulate the movement of ions, molecules, and cells between the blood and the
Richard, Daneman, Alexandre, Prat
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Structure and function of the blood-brain barrier.
Neurobiology of Disease, 2010 Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood–brain barrier (BBB), blood–CSF barrier and the arachnoid barrier.
N. Abbott +4 more
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The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
Nature Reviews Cancer, 2019 For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel wall to reach cancer cells in adequate quantities, and it must overcome the resistance conferred by the local microenvironment around cancer cells.
Costas D Arvanitis, Gino B Ferraro
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Development of the blood-brain barrier. [PDF]
DevelopmentABSTRACT The blood–brain barrier (BBB) is a term used to describe the specialized properties of vasculature in the central nervous system (CNS) that regulate the exchange of ions, molecules and cells, thereby maintaining CNS homeostasis.
Gastfriend BD, Daneman R.
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Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
Stroke, 2022 Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central nervous system (CNS). Structurally comprising the BBB, brain endothelial cells interact with pericytes, astrocytes, neurons, microglia, and perivascular ...
Eduardo Candelario-Jalil +2 more
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Pericytes are required for blood–brain barrier integrity during embryogenesis
Nature, 2010 Vascular endothelial cells in the central nervous system (CNS) form a barrier that restricts the movement of molecules and ions between the blood and the brain.
Richard Daneman +2 more
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Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
Nature Medicine, 2019 Vascular contributions to cognitive impairment are increasingly recognized1–5 as shown by neuropathological6,7, neuroimaging4,8–11, and cerebrospinal fluid biomarker4,12 studies.
Daniel A Nation +2 more
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APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
Nature, 2020 Vascular contributions to dementia and Alzheimer’s disease are increasingly recognized1–6. Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinical ...
Axel Montagne +2 more
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Blood brain barrier opening is not just blood-brain barrier opening
Journal of Translational MedicineDeepa Sharma, Gregory J. Czarnota
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