Results 31 to 40 of about 4,500,736 (296)

'Acanthamoeba' produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system [PDF]

, 2010
BACKGROUND: Many aspects of Acanthamoeba granulomatous encephalitis remain poorly understood, including host susceptibility and chronic colonization which represent important features of the spectrum of host-pathogen interactions.
Mortazavi, Parisa Nakhostin, Kirk, R., Goldsworthy, Graham, Parisa N Mortazavi, Ruth Kirk, Naveed A Khan, Kirk, Ruth, Khan, Naveed Ahmed, Khan, Naveed A, Goldsworthy, Graham J., Mortazavi, Parisa N, Graham Goldsworthy   +11 more
core   +1 more source

Blood—Brain Barrier Genomics [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2001
The blood–brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate ...
J Y, Li, R J, Boado, W M, Pardridge
openaire   +2 more sources

Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin b1 receptor agonist in a glioma rat model [PDF]

, 2012
Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of ...
Neugebauer Witold, Audrey Fortier, Martin Savard (163526), David Fortin (163586), Tsanaclis Ana-Maria, Céléna Dubuc, Jérôme Côté (163514), Céléna Dubuc (163533), Audrey Fortier (163543), Dubuc Céléna, Gobeil, Fernand, Müller-Esterl Werner, Fortin David, Neugebauer, Witold, Werner Müller-Esterl, Gobeil Fernand, Martin Savard, Fortier, Audrey, Tsanaclis, Ana-Maria, Witold Neugebauer (163552), Fernand Gobeil, Tremblay Luc, Luc Tremblay (163561), Lepage, Martin, Veronica Bovenzi (163520), Müller-Esterl, Werner, Bovenzi Veronica, David Fortin, Jérôme Côté, Ana-Maria Tsanaclis, Martin Lepage (125474), Fernand Gobeil Jr (163594), Savard Martin, Fortier Audrey, Dubuc, Céléna, Tremblay, Luc, Lepage Martin, Côté, Jérôme, Luc Tremblay, Martin Lepage, Ana-Maria Tsanaclis (163574), Bovenzi, Veronica, Savard, Martin, Veronica Bovenzi, Côté Jérôme, Fortin, David, Werner Müller-Esterl (37090), Witold Neugebauer   +47 more
core   +2 more sources

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

Journal of Neuroinflammation, 2023
Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML).
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt   +8 more
doaj   +1 more source

Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown [PDF]

, 2010
Background: An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation in non ...
Romero, Ignacio, Deiß Annika, Deiß, Annika, Buttmann, Mathias, Weksler Babette, Rieckmann, Peter, Ignacio Romero, Mathias Buttmann, Prochaska, Jürgen, Couraud, Pierre-Olivier, Jürgen Prochaska, Haarmann, Axel, Peter Rieckmann, Buttmann Mathias, Weksler, Babette, Axel Haarmann, Stoll, Guido, Najbauer, Joseph, Pierre-Olivier Couraud, Annika Deiss, Couraud Pierre-Olivier, Prochaska, Juergen, Stoll Guido, Guido Stoll, Förch, Christian, Romero Ignacio, Foerch, Christian, Prochaska Jürgen, Christian Foerch, Rieckmann Peter, Babette Weksler, Foerch Christian, Haarmann Axel   +32 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dissecting gene expression at the blood-brain barrier

Frontiers in Neuroscience, 2014
The availability of genome-wide expression data for the blood-brain barrier is an invaluable resource that has recently enabled the discovery of several genes and pathways involved in the development and maintenance of the blood-brain barrier ...
Melanie A Huntley, Nga eBien-Ly, Richard eDaneman, Ryan J Watts   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Investigating novel aspects of the blood-brain barrier using high resolution electron microscopy [PDF]

, 2022
Philosophiae Doctor - PhDThe blood-brain barrier (BBB) is a restrictive interface located between the blood circulation and the central nervous system (CNS), regulating the homeostatic environment of the neuronal milieu, by controlling the permeability
Mentor, Shireen
core   +1 more source