Results 31 to 40 of about 792,108 (354)

Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology

International Journal of Molecular Sciences, 2022
The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the BBB and, consequently, survival outcomes for malignant brain tumors ...
Andrew M Hersh, Safwan O. Alomari, B. Tyler   +2 more
semanticscholar   +1 more source

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source

'Acanthamoeba' produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system [PDF]

, 2010
BACKGROUND: Many aspects of Acanthamoeba granulomatous encephalitis remain poorly understood, including host susceptibility and chronic colonization which represent important features of the spectrum of host-pathogen interactions.
Mortazavi, Parisa Nakhostin, Kirk, R., Goldsworthy, Graham, Parisa N Mortazavi, Ruth Kirk, Naveed A Khan, Kirk, Ruth, Khan, Naveed Ahmed, Khan, Naveed A, Goldsworthy, Graham J., Mortazavi, Parisa N, Graham Goldsworthy   +11 more
core   +1 more source

Development, maintenance and disruption of the blood-brain barrier

Nature Medicine, 2013
The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the term 'blood-brain barrier' (BBB).
B. Obermeier, R. Daneman, R. Ransohoff
semanticscholar   +1 more source

Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

Investigating novel aspects of the blood-brain barrier using high resolution electron microscopy [PDF]

, 2022
Philosophiae Doctor - PhDThe blood-brain barrier (BBB) is a restrictive interface located between the blood circulation and the central nervous system (CNS), regulating the homeostatic environment of the neuronal milieu, by controlling the permeability
Mentor, Shireen
core   +1 more source

P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Nature Materials, 2023
Targeting of tumour vasculature endothelial P-selectin promotes caveolin-1-mediated transcytosis for enhanced blood–brain barrier crossing of therapeutic nanoparticles against medulloblastoma. Medulloblastoma is the most common malignant paediatric brain
Daniel E Tylawsky, Hiroto Kiguchi, Jake Vaynshteyn, Jeffrey Gerwin, Janki Shah, Taseen Islam, Jacob A Boyer, D. Boue, M. Snuderl, M. Greenblatt, Yosi Shamay, G. P. Raju, Daniel A. Heller   +12 more
semanticscholar   +1 more source

Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown [PDF]

, 2010
Background: An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation in non ...
Romero, Ignacio, Deiß Annika, Deiß, Annika, Buttmann, Mathias, Weksler Babette, Rieckmann, Peter, Ignacio Romero, Mathias Buttmann, Prochaska, Jürgen, Couraud, Pierre-Olivier, Jürgen Prochaska, Haarmann, Axel, Peter Rieckmann, Buttmann Mathias, Weksler, Babette, Axel Haarmann, Stoll, Guido, Najbauer, Joseph, Pierre-Olivier Couraud, Annika Deiss, Couraud Pierre-Olivier, Prochaska, Juergen, Stoll Guido, Guido Stoll, Förch, Christian, Romero Ignacio, Foerch, Christian, Prochaska Jürgen, Christian Foerch, Rieckmann Peter, Babette Weksler, Foerch Christian, Haarmann Axel   +32 more
core   +1 more source

The blood–brain barrier in systemic infection and inflammation

Cellular & Molecular Immunology, 2021
The vascular blood–brain barrier is a highly regulated interface between the blood and brain. Its primary function is to protect central neurons while signaling the presence of systemic inflammation and infection to the brain to enable a protective ...
Ian Galea
semanticscholar   +1 more source

Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain [PDF]

, 2004
The aim of this study was to evaluate glucose-bearing niosomes as a brain targeted delivery system for the vasoactive intestinal peptide (VIP). To this end, VIP/125I-VIP-loaded glucose-bearing niosomes were intravenously injected to mice.
Dufès, Christine, Schätzlein, Andreas G., Gaillard, F., Uchegbu, I.F., Dufes, C., Muller, J.M., Gaillard, Frédéric, Olivier, Jean-Christophe, Muller, Jean-Marc, Schatzlein, A.G., Olivier, J.C.   +10 more
core   +1 more source