Results 1 to 10 of about 681,701 (257)

In vitro model of the blood-brain barrier established by co-culture of primary cerebral microvascular endothelial and astrocyte cells

Neural Regeneration Research, 2015
Drugs for the treatment and prevention of nervous system diseases must permeate the blood-brain barrier to take effect. In vitro models of the blood-brain barrier are therefore important in the investigation of drug permeation mechanisms.
Yan Wang, Ning Wang, Biao Cai, Guang-yun Wang, Jing Li, Xing-xing Piao   +5 more
doaj   +1 more source

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

Barrier mechanisms in the Drosophila blood-brain barrier

Frontiers in Neuroscience, 2014
The invertebrate blood-brain barrier field is growing at a rapid pace and, in recent years, studies have shown a physiologic and molecular complexity that has begun to rival its vertebrate counterpart. Novel mechanisms of paracellular barrier maintenance
Samantha Jane Hindle, Roland Jerome Bainton   +1 more
doaj   +1 more source

Measuring Blood-brain-barrier Permeability Using Evans Blue in Mice

Bio-Protocol, 2015
The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid in the central nervous system.
Jun-Xia Yang, Yan-Yu Jiang, Yu-Bai Guo
doaj   +1 more source

Effects of HIV and Drugs of Abuse on the Blood-Brain Barrier [PDF]

, 2016
Despite effective systemic therapy, HIV-1 infection within the brain results in neuronal degradation and neurocognitive dysfunction. This neurocognitive dysfunction is worsened in the setting of opiate abuse. The central nervous system (CNS) is protected
Hari, Gopika
core   +1 more source

Posterior reversible encephalopathy syndrome (PRES) after bevacizumab therapy for metastatic colorectal cancer. [PDF]

, 2018
Posterior reversible encephalopathy syndrome (PRES) is an increasingly recognizable neuro-clinical syndrome. Clinical and neurological manifestations of PRES include hypertension, headache, encephalopathy, seizures, and symmetrical white matter changes ...
Ghani, Ali, Hamid, Mohsin, Lashari, MD, Bilal, Malik, Faizan, Micaily, Ida, Sarwar, MD, Usman   +5 more
core   +2 more sources

Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. [PDF]

, 2014
UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system.
Bautos, Jennifer M, Gelli, Angie, Jamklang, Mantana, Na Pombejra, Sarisa, Tham, Rick, Thompson, George R, Uhrig, John P, Vu, Kiem   +7 more
core   +2 more sources

Rebuilding insight into the pathophysiology of Alzheimer's disease through new blood-brain barrier models

Neural Regeneration Research
The blood-brain barrier is a unique function of the microvasculature in the brain parenchyma that maintains homeostasis in the central nervous system. Blood-brain barrier breakdown is a common pathology in various neurological diseases, such as Alzheimer'
Kinya Matsuo, Hideaki Nshihara
doaj   +1 more source

Glucose transporters in the blood-brain barrier [PDF]

, 2012
The central nervous system and peripheral nerves are guarded against free access from the outside by the blood-brain, blood-cerebrospinal fluid and blood-nerve barriers. The glucose transporter GLUT1 mediates the specific transfer of glucose across these
Benno, Indrek, Hussar, Piret, Hussar, Ülo   +2 more
core   +3 more sources

Assessing Blood Brain Barrier Permeability in Traumatic Brain Injury Research

ADMET and DMPK, 2015
The blood brain barrier plays an important role in traumatic brain injury, serving at the crossroads of secondary injury and potential therapies. In regards to trauma, this barrier contains an array of cellular and molecular components that protect the ...
George P. Liao, Benjamin M. Aertker, Daniel J. Kota, Karthik S. Prabhakara, Philipp Smith, Robert A. Hetz, Hasen Xue, Supinder Bedi, Scott D. Olson, Charles S. Cox   +9 more
doaj   +1 more source